Virus-specific T cells play an important role in the resolution of hepatic infection. However, during chronic hepatitis infection these cells lack their effector functions and fail to control the virus. Hepatitis B vi...Virus-specific T cells play an important role in the resolution of hepatic infection. However, during chronic hepatitis infection these cells lack their effector functions and fail to control the virus. Hepatitis B virus and hepatitis C virus have developed several mechanisms to generate immune tolerance. One of these strategies is the depletion of virus-specific T cells by apoptosis. The immunotolerogenic liver has unique property to retain and activate na ve T cell to avoid the over reactivation of immune response against antigens which is exploited by hepatotropic viruses to persist. The deletion of the virus-specific T cells occurs by intrinsic (passive) apoptotic mechanism. The pro-apoptotic molecule Bcl-2 interacting mediator (Bim) has attracted increasing attention as a pivotal involvement in apoptosis, as a regulator of tissue homeostasis and an enhancer for the viral persistence. Here, we reviewed our current knowledge on the evidence showing critical role of Bim in viral-specific T cell death by apoptotic pathways and helps in the immune tolerance.展开更多
文摘目的 探讨宫颈癌放疗患者放疗前CD4^(+)/CD8^(+)、B淋巴细胞、抑制/细胞毒性T细胞联合预测放射性肠炎(RE)的价值。方法 回顾性分析2019年1月至2021年3月在中国科学院合肥肿瘤医院接受放疗的87例宫颈癌患者的临床资料,根据患者是否发生RE将患者分为RE组(n=27)和非RE组(n=60),并根据常见不良反应事件评价标准将RE组中≥2级者归为高症状级别组(HRE组,n=17),1级者归为低症状级别组(LRE组,n=10)。比较患者放疗前血浆CD4^(+)/CD8^(+)、B淋巴细胞、抑制/细胞毒性T细胞,采用受试者工作特征(ROC)曲线分析放疗前CD4^(+)/CD8^(+)、B淋巴细胞、抑制/细胞毒性T细胞预测RE的价值。结果 放疗前RE组患者抑制/细胞毒性T细胞高于非RE组患者(35.04±2.39 vs 24.86±1.05),CD4^(+)/CD8^(+)(0.87±0.10 vs 1.88±0.13)、B淋巴细胞(6.60%±1.11%vs 10.45%±0.54%)低于非RE组患者,差异有统计学意义(P<0.01)。HRE组抑制/细胞毒性T细胞高于LRE组,CD4^(+)/CD8^(+)、B淋巴细胞低于LRE组,差异有统计学意义(P<0.05,P<0.01)。CD4^(+)/CD8^(+)、B淋巴细胞、抑制/细胞毒性T细胞值预测RE的截断值分别为1.15、4.95%、26.85。CD4^(+)/CD8^(+)预测RE的AUC为0.798(95%CI:0.733~0.901);B淋巴细胞预测RE的AUC为0.74(95%CI:0.634~0.828);抑制/细胞毒性T细胞预测RE的AUC为0.762(95%CI:0.658~0.847);三者联合预测RE的AUC为0.901(95%CI:0.795~0.941);联合检测时AUC分别明显高于三者单独检测,差异均有统计学意义(P<0.05)。结论 宫颈癌患者CD4^(+)/CD8^(+)、B淋巴细胞、抑制/细胞毒性T细胞与RE发生率密切相关,CD4^(+)/CD8^(+)越低,B淋巴细胞下降越明显,抑制/细胞毒性T细胞增加越高预示着细胞免疫功能失衡越严重,RE发生的概率越高。
基金Supported by Grants from "Fiscam" JCCM, Ayuda para proyectos de investigación en salud, PI-2010/022"Fundación de Investigación Médica Mutua Madrilea", Beca Ayudas a la Investigación FMMM, 8922/2011A research grant from "Asociación de Hepatología Translacional", No. AHT 2010-01, to Lokhande MU
文摘Virus-specific T cells play an important role in the resolution of hepatic infection. However, during chronic hepatitis infection these cells lack their effector functions and fail to control the virus. Hepatitis B virus and hepatitis C virus have developed several mechanisms to generate immune tolerance. One of these strategies is the depletion of virus-specific T cells by apoptosis. The immunotolerogenic liver has unique property to retain and activate na ve T cell to avoid the over reactivation of immune response against antigens which is exploited by hepatotropic viruses to persist. The deletion of the virus-specific T cells occurs by intrinsic (passive) apoptotic mechanism. The pro-apoptotic molecule Bcl-2 interacting mediator (Bim) has attracted increasing attention as a pivotal involvement in apoptosis, as a regulator of tissue homeostasis and an enhancer for the viral persistence. Here, we reviewed our current knowledge on the evidence showing critical role of Bim in viral-specific T cell death by apoptotic pathways and helps in the immune tolerance.
