摘要
细胞毒T细胞(CTL)分为CD8+CTLs、CD4+CTLs和CD4-CD8-CTLs几个亚群,它来源于淋巴样造血干细胞的T细胞库,在胸腺中发育成熟,并在周围淋巴组织中活化。效应CTL对靶细胞实行杀伤的途径主要有两条:FasL-Fas介导的细胞凋亡作用和颗粒胞吐途径介导的溶细胞作用。由于CTL在抗肿瘤和抗病毒中效应显著,因而受到广泛重视。
Department of Immunology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing100005 Cytotoxic T cell(CTL)covers several subtypes,which are CD8 + ,CD4and CD4 - CD8 - .CTL derives from T cell repertoire in lymphoid hematopoietic stem cells.It matures in thymus and is activated in peripheral lymphoid tissues.Effector CTL kills the target cells by2ways.One is apoptotic effect mediated by FasL-Fas pathway and the other one is cytolytic effect mediated by granzymes.CTL has aroused great attention due to its significance in anti-tumor and anti-virus.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2002年第4期439-442,共4页
Acta Academiae Medicinae Sinicae
