目的评价、探索肠道病毒71型(enterovirus 71,EV71)灭活疫苗与免疫规划疫苗中的重组乙型肝炎疫苗(hepatitis B vaccine,HepB)、乙型脑炎减毒活疫苗(live-attenuated Japanese encephalitis vaccine,LJEV)联合接种的效果及可行性,为EV71...目的评价、探索肠道病毒71型(enterovirus 71,EV71)灭活疫苗与免疫规划疫苗中的重组乙型肝炎疫苗(hepatitis B vaccine,HepB)、乙型脑炎减毒活疫苗(live-attenuated Japanese encephalitis vaccine,LJEV)联合接种的效果及可行性,为EV71灭活疫苗与免疫规划疫苗联合接种提供科学依据。方法采用随机、对照、多中心的研究方法,通过分层区组随机化方法给符合标准的对象分配研究编号入组,评价各组6/8月龄婴儿EV71灭活疫苗第1剂与重组HepB第3剂、LJEV第1剂联合接种的免疫原性及可操作性。结果EV71灭活疫苗与重组HepB第3剂联合免疫组(HepB:3+EV71组)和重组HepB单独接种组(HepB:3组)的HBsAb浓度的中位数免疫前分别为575.19 mIU/mlh和592.97 mIU/ml,差异无统计学意义(P>0.05);免疫后两组中位数分别为2766.11 mIU/ml和2153.63 mIU/ml,差异无统计学意义(P>0.05);EV71灭活疫苗与LJEV联合免疫组(LJEV+EV71组)和LJEV单独接种组(LJEV组)乙脑中和抗体滴度几何均值免疫前分别为1∶5.00和1∶5.13,差异无统计学意义(P>0.05);免疫后两组乙脑中和抗体滴度几何均值分别为1∶11.55和1∶9.75,差异无统计学意义(P>0.05);HepB:3+EV71组HBsAb阳转率为48.08%,HepB:3组HBsAb阳转率为51.85%,两组差异无统计学意义(P>0.05);LJEV+EV71组乙脑抗体阳转率为67.92%,LJEV组乙脑抗体阳转率为59.26%,两组差异无统计学意义(P>0.05);所有试验组(联合接种组)和EV71灭活疫苗单独接种组(EV71组)免疫后EV71中和抗体均阳转,免疫前EV71组的EV71中和抗体滴度几何均值为1∶4.21,HepB:3+EV71组为1∶4.62,两者差异无统计学意义(P>0.05),LJEV+EV71组为1∶4.16,与EV71组差异无统计学意义(P>0.05);免疫后EV71组的EV71中和抗体滴度几何均值为1∶612.93,HepB:3+EV71组为1∶1169.45,LJEV+EV71组为1∶1156.49,均高于EV71组,差异有统计学意义(P<0.05)。结论EV71灭活疫苗单独接种及EV71灭活疫苗分别与重组HepB、LJEV联合接种,其免疫后EV71中展开更多
In order to increase the convenience of application and minimize logistical problems in the recent years, the use of combined vaccines has become a growing trend. The use of combined vaccines offers benefits such as, ...In order to increase the convenience of application and minimize logistical problems in the recent years, the use of combined vaccines has become a growing trend. The use of combined vaccines offers benefits such as, a reduction in the number of patient visits, less complications which are associated with multiple intramuscular drilling and other risks. In 1997 the Department of Epidemiology （DE） of Institute of Public Health initiated and carried out conspicuous quantitative and qualitative modifications of up-to-them statutory notification system thus compiling the new Major Disease-Based Epidemiological Surveillance System. Mandatory reporting system on Measles/Rubella Case-Based Surveillance represents in itself an addendum of the statutory reporting system of infectious diseases. These diseases are enlisted in the Group B of the 14/Sh Form. Diphtheria is enlisted in the Group A containing the infectious diseases of the highest public health importance. They are subject of a mandatory urgent notification from the basic level. The aim of this study is to examine and check up the effectiveness of combined vaccines in our country, through the evaluation of the data from national epidemiologic surveillance verifying the distributions in time and space of these diseases in relation to the history of vaccination policies in Albania.展开更多
文摘In order to increase the convenience of application and minimize logistical problems in the recent years, the use of combined vaccines has become a growing trend. The use of combined vaccines offers benefits such as, a reduction in the number of patient visits, less complications which are associated with multiple intramuscular drilling and other risks. In 1997 the Department of Epidemiology （DE） of Institute of Public Health initiated and carried out conspicuous quantitative and qualitative modifications of up-to-them statutory notification system thus compiling the new Major Disease-Based Epidemiological Surveillance System. Mandatory reporting system on Measles/Rubella Case-Based Surveillance represents in itself an addendum of the statutory reporting system of infectious diseases. These diseases are enlisted in the Group B of the 14/Sh Form. Diphtheria is enlisted in the Group A containing the infectious diseases of the highest public health importance. They are subject of a mandatory urgent notification from the basic level. The aim of this study is to examine and check up the effectiveness of combined vaccines in our country, through the evaluation of the data from national epidemiologic surveillance verifying the distributions in time and space of these diseases in relation to the history of vaccination policies in Albania.
