AIM To assess the possible roles of cytokines (TNF α, IFN γ, IL 6 and IL 8) in liver damage of hepatitis B. METHODS The serum TNF α, IFN γ, IL 6 and IL 8 were detected by ELISA in 66 patients with hepat...AIM To assess the possible roles of cytokines (TNF α, IFN γ, IL 6 and IL 8) in liver damage of hepatitis B. METHODS The serum TNF α, IFN γ, IL 6 and IL 8 were detected by ELISA in 66 patients with hepatitis B and 20 healthy blood donors. RESULTS TNF α and IL 6 in all types of clinical hepatitis B were significantly higher than those in healthy blood donors ( P <0 05); meanwhile the levels of TNF α, IFN γ, IL 6 and IL 8 in the patients with fulminant hepatitis B were much higher than those in the patients with acute hepatitis B ( P <0 05); the level of TNF α was positively correlated with the levels of IFN γ, Il 6 and IL 8 in all types of hepatitis B ( r IFN =0 24, r IL 6 =0 35, r IL 8 =0 44) and the TNF α, IFN γ, IL 6 and IL 8 were positively correlated with serum bilirubin ( P <0 05). Dynamic changes of these cytokines were observed in the course of acute and fulminant hepatitis. The level of IFN γ peaked in the initial period of acute hepatitis and early stage of hepatic coma in fulminant hepatitis; TNF α, IL 6 and IL 8 increased with exacerbation, and reached a peak when the liver damage was most serious, then decreased when patient conditions were improved. CONCLUSION The increased cytokines were related to the inflammation of liver cells and multiple factors may play certain roles in liver damage.展开更多
利用卫星影像快速准确地提取湖泊等地表水体范围一直是一个重要的研究课题,其对洪涝灾害监测、水资源管理与利用等具有重要意义。Sentinel-2 MSI和Landsat8 OLI数据是目前主流的开放获取的中高空间分辨率遥感影像。以鄱阳湖区为研究对象...利用卫星影像快速准确地提取湖泊等地表水体范围一直是一个重要的研究课题,其对洪涝灾害监测、水资源管理与利用等具有重要意义。Sentinel-2 MSI和Landsat8 OLI数据是目前主流的开放获取的中高空间分辨率遥感影像。以鄱阳湖区为研究对象,首先,分别使用归一化差异水体指数(normalized difference water index,NDWI)、改进的归一化差异水体指数(modified normalized difference water index,MNDWI)、自动水体提取指数(automated water extraction index,AWEI sh )和基于线性判别分析的水体指数(water index,WI 2015 )等4种常用的水体指数从2种影像中提取湖泊水体的分布信息;然后,分析了在同种水体指数之下2种影像提取结果的差异性和同一幅影像中4种水体指数提取结果的不同;最后,利用同期的高分一号影像目视解译的结果对水体提取结果进行了精度验证。结果表明,对于2种遥感影像,4种水体指数均能成功地提取出研究区的大部分水体;AWEI sh 和WI 2015 的提取精度最高,在Sentinel-2和Landsat8影像上分别达到了98%和94%以上,MNDWI次之,NDWI的提取精度最低;相对而言,Sentinel-2影像提取的水体细部信息更为明显,整体提取效果优于Landsat8影像。展开更多
文摘AIM To assess the possible roles of cytokines (TNF α, IFN γ, IL 6 and IL 8) in liver damage of hepatitis B. METHODS The serum TNF α, IFN γ, IL 6 and IL 8 were detected by ELISA in 66 patients with hepatitis B and 20 healthy blood donors. RESULTS TNF α and IL 6 in all types of clinical hepatitis B were significantly higher than those in healthy blood donors ( P <0 05); meanwhile the levels of TNF α, IFN γ, IL 6 and IL 8 in the patients with fulminant hepatitis B were much higher than those in the patients with acute hepatitis B ( P <0 05); the level of TNF α was positively correlated with the levels of IFN γ, Il 6 and IL 8 in all types of hepatitis B ( r IFN =0 24, r IL 6 =0 35, r IL 8 =0 44) and the TNF α, IFN γ, IL 6 and IL 8 were positively correlated with serum bilirubin ( P <0 05). Dynamic changes of these cytokines were observed in the course of acute and fulminant hepatitis. The level of IFN γ peaked in the initial period of acute hepatitis and early stage of hepatic coma in fulminant hepatitis; TNF α, IL 6 and IL 8 increased with exacerbation, and reached a peak when the liver damage was most serious, then decreased when patient conditions were improved. CONCLUSION The increased cytokines were related to the inflammation of liver cells and multiple factors may play certain roles in liver damage.
文摘利用卫星影像快速准确地提取湖泊等地表水体范围一直是一个重要的研究课题,其对洪涝灾害监测、水资源管理与利用等具有重要意义。Sentinel-2 MSI和Landsat8 OLI数据是目前主流的开放获取的中高空间分辨率遥感影像。以鄱阳湖区为研究对象,首先,分别使用归一化差异水体指数(normalized difference water index,NDWI)、改进的归一化差异水体指数(modified normalized difference water index,MNDWI)、自动水体提取指数(automated water extraction index,AWEI sh )和基于线性判别分析的水体指数(water index,WI 2015 )等4种常用的水体指数从2种影像中提取湖泊水体的分布信息;然后,分析了在同种水体指数之下2种影像提取结果的差异性和同一幅影像中4种水体指数提取结果的不同;最后,利用同期的高分一号影像目视解译的结果对水体提取结果进行了精度验证。结果表明,对于2种遥感影像,4种水体指数均能成功地提取出研究区的大部分水体;AWEI sh 和WI 2015 的提取精度最高,在Sentinel-2和Landsat8影像上分别达到了98%和94%以上,MNDWI次之,NDWI的提取精度最低;相对而言,Sentinel-2影像提取的水体细部信息更为明显,整体提取效果优于Landsat8影像。
