Hyperlipidemia, type 2 diabetes mellitus, nonalcoholic fatty liver and many other metabolic disorder are frequently co-existing in patients. In addition, these diseases are closely related in pathophysiological settin...Hyperlipidemia, type 2 diabetes mellitus, nonalcoholic fatty liver and many other metabolic disorder are frequently co-existing in patients. In addition, these diseases are closely related in pathophysiological settings. However, increasing of the disease incidence, lacking of comprehensive prevention and control measurements against the key pathology point concomitant occurrence with the pattem of the single disease, single target therapy, that is leading therapeutic strategy for these metabolic disorders in the setting of Western medicine （WM）. On the basis of the combination of the advantages of integrated Chinese medicine （CM） and WM, with unified understanding of such diseases, the new concept of glucolipid metabolic disease （GLMD） is introduced. In this new concept, disorders in glucose and lipid metabolism are recognized as the key trigger and major driving force for the progress of GLMD. The key points of pathology included dysfunction of neuronal-endocrine-immune system,insulin resistance, oxidative stress, inflammation and intestinal flora imbalance. In the core pathogenic perspective of CM, it can be explained as ＂Gan （Liver） Shi Shu Xie＂ （dysfunction of Gan in metabolism and emotion regulation） that will lead to the occurence/production of endogenous dampness and phlegm, blood stasis and turbid. This leads to the new concept of ＂Liver-based regulatory system for metabolic homeostasis＂ to be introduced further. The comprehensive prevention and control strategy ＂Tiao Gan Qi Shu Hua Zhuo＂ （modulating Gan, trigging key metabolic system to resolve pathogenic factors such as phlegm retention and dampness）. Its representative formula Fufang Zhenzhu Tiaozhi Capsule （复方贞术调脂胶囊） is innovated under such rationales. Comment for some commonly-used CM GLMD therapeutic drugs was presented. High-level evidence-based and epidemiological and mechanism studies should be carded out to further interpret and explain of the scientific connotation of GLMD.展开更多
Two new unsaturated alkylamides （2E,7E,9E）-N-（2-hydroxy-2-methylpropyl）-6,11-dioxo-2,7,9-dodecatrienamide （1） and （2E,6E,8E）-N-（2-hydroxy-2-methylpropyl）-10-oxo-2,6,8-decatrienamide （2） together with six k...Two new unsaturated alkylamides （2E,7E,9E）-N-（2-hydroxy-2-methylpropyl）-6,11-dioxo-2,7,9-dodecatrienamide （1） and （2E,6E,8E）-N-（2-hydroxy-2-methylpropyl）-10-oxo-2,6,8-decatrienamide （2） together with six known compounds （3-8） have been isolated from the pericarps of Zanthoxylum bungeanum. Their structures were elucidated on the basis of extensive spectroscopic analysis, including MS, IR, 1D and 2D NMR experiments.展开更多
In this paper, we give an explicit formula of the Bergman kernel function on Hua Construction of the second type when the parameters 1/p1,…, 1/pr-1 are positive integers and 1/pr is an arbitrary positive real number.
Six granite samples were collected from six difference elevation locations at the Hua Shan in a main ridge of the Qinling Mountain. Apatite and zircon separated from these six samples were dated by the fission track t...Six granite samples were collected from six difference elevation locations at the Hua Shan in a main ridge of the Qinling Mountain. Apatite and zircon separated from these six samples were dated by the fission track technique. An assessment of the Cenozoic uplift or exhumation rate was obtained from the altitude difference of sampling samples dated by fission track, and from the difference of fission track dates of both apatite and zircon for a sample. The preliminary results suggest that the beginning of uplift of the Hua Shan was as early as 68.2 MaBP and the uplift rates for different periods are 0.02-0.19 mm/a (from the elevation difference) or 0.12-0.16 mm/a (from two mineral fission track dates). The average uplift rate is 0.12 mm/a (from the elevation difference) or 0.14 mm/a (from two mineral fission track dates). The uplift of the Hua Shan might accelerate since (17.8±2.0) MaBP, and the average uplift rate is about 0.19 mm/a.展开更多
We introduce two classes of egg type domains, built on general boundedsymmetric domains, for which we obtain the Bergman kernel inexplicit formulas. As an auxiliary tool, we compute the integralof complex powers of th...We introduce two classes of egg type domains, built on general boundedsymmetric domains, for which we obtain the Bergman kernel inexplicit formulas. As an auxiliary tool, we compute the integralof complex powers of the generic norm on a bounded symmetricdomains using the well-known integral of Selberg. Thisgeneralizes matrix integrals of Hua and leads to a specialpolynomial with integer or half-integer coefficients attached toeach irreducible bounded symmetric domain.展开更多
基金Supported by the National Natural Science Foundation of China(No.81173626,81530102,and 30973913)
文摘Hyperlipidemia, type 2 diabetes mellitus, nonalcoholic fatty liver and many other metabolic disorder are frequently co-existing in patients. In addition, these diseases are closely related in pathophysiological settings. However, increasing of the disease incidence, lacking of comprehensive prevention and control measurements against the key pathology point concomitant occurrence with the pattem of the single disease, single target therapy, that is leading therapeutic strategy for these metabolic disorders in the setting of Western medicine （WM）. On the basis of the combination of the advantages of integrated Chinese medicine （CM） and WM, with unified understanding of such diseases, the new concept of glucolipid metabolic disease （GLMD） is introduced. In this new concept, disorders in glucose and lipid metabolism are recognized as the key trigger and major driving force for the progress of GLMD. The key points of pathology included dysfunction of neuronal-endocrine-immune system,insulin resistance, oxidative stress, inflammation and intestinal flora imbalance. In the core pathogenic perspective of CM, it can be explained as ＂Gan （Liver） Shi Shu Xie＂ （dysfunction of Gan in metabolism and emotion regulation） that will lead to the occurence/production of endogenous dampness and phlegm, blood stasis and turbid. This leads to the new concept of ＂Liver-based regulatory system for metabolic homeostasis＂ to be introduced further. The comprehensive prevention and control strategy ＂Tiao Gan Qi Shu Hua Zhuo＂ （modulating Gan, trigging key metabolic system to resolve pathogenic factors such as phlegm retention and dampness）. Its representative formula Fufang Zhenzhu Tiaozhi Capsule （复方贞术调脂胶囊） is innovated under such rationales. Comment for some commonly-used CM GLMD therapeutic drugs was presented. High-level evidence-based and epidemiological and mechanism studies should be carded out to further interpret and explain of the scientific connotation of GLMD.
基金supported by the National Natural Science Foundation of China(Nos.31171695 and 21142004)the New Century Talents Scheme of the Ministry of Education(No.NCET-08-0820)the Fundamental Research Funds for Central Universities(No.SWJTU2010ZT09)
文摘Two new unsaturated alkylamides （2E,7E,9E）-N-（2-hydroxy-2-methylpropyl）-6,11-dioxo-2,7,9-dodecatrienamide （1） and （2E,6E,8E）-N-（2-hydroxy-2-methylpropyl）-10-oxo-2,6,8-decatrienamide （2） together with six known compounds （3-8） have been isolated from the pericarps of Zanthoxylum bungeanum. Their structures were elucidated on the basis of extensive spectroscopic analysis, including MS, IR, 1D and 2D NMR experiments.
文摘In this paper, we give an explicit formula of the Bergman kernel function on Hua Construction of the second type when the parameters 1/p1,…, 1/pr-1 are positive integers and 1/pr is an arbitrary positive real number.
基金This work was supported by the NationalNatural Science Foundation of China (Grant Nos. 49732090 and 49872062).
文摘Six granite samples were collected from six difference elevation locations at the Hua Shan in a main ridge of the Qinling Mountain. Apatite and zircon separated from these six samples were dated by the fission track technique. An assessment of the Cenozoic uplift or exhumation rate was obtained from the altitude difference of sampling samples dated by fission track, and from the difference of fission track dates of both apatite and zircon for a sample. The preliminary results suggest that the beginning of uplift of the Hua Shan was as early as 68.2 MaBP and the uplift rates for different periods are 0.02-0.19 mm/a (from the elevation difference) or 0.12-0.16 mm/a (from two mineral fission track dates). The average uplift rate is 0.12 mm/a (from the elevation difference) or 0.14 mm/a (from two mineral fission track dates). The uplift of the Hua Shan might accelerate since (17.8±2.0) MaBP, and the average uplift rate is about 0.19 mm/a.
文摘We introduce two classes of egg type domains, built on general boundedsymmetric domains, for which we obtain the Bergman kernel inexplicit formulas. As an auxiliary tool, we compute the integralof complex powers of the generic norm on a bounded symmetricdomains using the well-known integral of Selberg. Thisgeneralizes matrix integrals of Hua and leads to a specialpolynomial with integer or half-integer coefficients attached toeach irreducible bounded symmetric domain.
