Bone mass is a key determinant of osteoporosis and fragility fractures.Epidemiologic studies have shown that a 10%increase in peak bone mass(PBM)at the population level reduces the risk of fracture later in life by 50...Bone mass is a key determinant of osteoporosis and fragility fractures.Epidemiologic studies have shown that a 10%increase in peak bone mass(PBM)at the population level reduces the risk of fracture later in life by 50%.Low PBM is possibly due to the bone loss caused by various conditions or processes that occur during adolescence and young adulthood.Race,gender,and family history(genetics)are responsible for the majority of PBM,but other factors,such as physical activity,calcium and vitamin D intake,weight,smoking and alcohol consumption,socioeconomic status,age at menarche,and other secondary causes(diseases and medications),play important roles in PBM gain during childhood and adolescence.Hence,the optimization of lifestyle factors that affect PBM and bone strength is an important strategy to maximize PBM among adolescents and young people,and thus to reduce the low bone mass or osteoporosis risk in later life.This review aims to summarize the available evidence for the common but important factors that influence bone mass gain during growth and development and discuss the advances of developing high PBM.展开更多
目的通过测量乌鲁木齐市1837人次汉族、维吾尔族健康人群的骨密度（Bone Mineral DensityBMD）．确定本地区汉族、维吾尔族DXA测量骨密度的正常参考值范围，建立本地区汉族、维吾尔族DXA测量骨密度的正常数据库，并比较、探讨汉族、维...目的通过测量乌鲁木齐市1837人次汉族、维吾尔族健康人群的骨密度（Bone Mineral DensityBMD）．确定本地区汉族、维吾尔族DXA测量骨密度的正常参考值范围，建立本地区汉族、维吾尔族DXA测量骨密度的正常数据库，并比较、探讨汉族、维吾尔族BMD随年龄变化的规律。方法使用法国DMS公司生产的Lexxos型双能x线骨密度仪（Duelenergy X-ray absorptiometer，DEXA）对乌鲁木齐地区20，75岁以上的汉族、维吾尔族健康人群的腰椎前后位、左侧股骨近端进行BMD测定。按不同性别每5岁分为一年龄组，得出骨密度均值、标准差，并进行两组样本均数的f检验。结果汉族、维吾尔族男性及女性各部位出现骨峰值的年龄段略有不同，但多数均在40岁前随骨量逐渐增加而达到骨峰值。其后随年龄的增长BMD降低，女性BMD在50岁后加速下降，男性无加速下降的趋势。结论本研究建立了乌鲁木齐市汉族、维吾尔族DXA测量常规检查部位各年龄段BMD的正常值及骨质疏松诊断参考值，为今后骨质疏松的预防、诊断、研究提供了客观数据，也为国内的资料比较提供了依据。展开更多
基金supported by the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China(No.LR17H070001)the National Natural Science Foundation of China(No.81871831).
文摘Bone mass is a key determinant of osteoporosis and fragility fractures.Epidemiologic studies have shown that a 10%increase in peak bone mass(PBM)at the population level reduces the risk of fracture later in life by 50%.Low PBM is possibly due to the bone loss caused by various conditions or processes that occur during adolescence and young adulthood.Race,gender,and family history(genetics)are responsible for the majority of PBM,but other factors,such as physical activity,calcium and vitamin D intake,weight,smoking and alcohol consumption,socioeconomic status,age at menarche,and other secondary causes(diseases and medications),play important roles in PBM gain during childhood and adolescence.Hence,the optimization of lifestyle factors that affect PBM and bone strength is an important strategy to maximize PBM among adolescents and young people,and thus to reduce the low bone mass or osteoporosis risk in later life.This review aims to summarize the available evidence for the common but important factors that influence bone mass gain during growth and development and discuss the advances of developing high PBM.
文摘目的通过测量乌鲁木齐市1837人次汉族、维吾尔族健康人群的骨密度（Bone Mineral DensityBMD）．确定本地区汉族、维吾尔族DXA测量骨密度的正常参考值范围，建立本地区汉族、维吾尔族DXA测量骨密度的正常数据库，并比较、探讨汉族、维吾尔族BMD随年龄变化的规律。方法使用法国DMS公司生产的Lexxos型双能x线骨密度仪（Duelenergy X-ray absorptiometer，DEXA）对乌鲁木齐地区20，75岁以上的汉族、维吾尔族健康人群的腰椎前后位、左侧股骨近端进行BMD测定。按不同性别每5岁分为一年龄组，得出骨密度均值、标准差，并进行两组样本均数的f检验。结果汉族、维吾尔族男性及女性各部位出现骨峰值的年龄段略有不同，但多数均在40岁前随骨量逐渐增加而达到骨峰值。其后随年龄的增长BMD降低，女性BMD在50岁后加速下降，男性无加速下降的趋势。结论本研究建立了乌鲁木齐市汉族、维吾尔族DXA测量常规检查部位各年龄段BMD的正常值及骨质疏松诊断参考值，为今后骨质疏松的预防、诊断、研究提供了客观数据，也为国内的资料比较提供了依据。
