Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation(DNAm)at specific CpG sites.However,a systematic comparison between DNA methylation data and other omics dat...Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation(DNAm)at specific CpG sites.However,a systematic comparison between DNA methylation data and other omics datasets has not yet been performed.Moreover,available DNAm age predictors are based on datasets with limited ethnic representation.To address these knowledge gaps,we generated and analyzed DNA methylation datasets from two independent Chinese cohorts,revealing age-related DNAm changes.Additionally,a DNA methylation aging clock(iCAS-DNAmAge)and a group of DNAm-based multi-modal clocks for Chinese individuals were developed,with most of them demonstrating strong predictive capabilities for chronological age.The clocks were further employed to predict factors influencing aging rates.The DNAm aging clock,derived from multi-modal aging features(compositeAge-DNAmAge),exhibited a close association with multi-omics changes,lifestyles,and disease status,underscoring its robust potential for precise biological age assessment.Our findings offer novel insights into the regulatory mechanism of age-related DNAm changes and extend the application of the DNAm clock for measuring biological age and aging pace,providing the basis for evaluating aging intervention strategies.展开更多
A pelvic endoprosthesis is the primary means of pelvic reconstruction after internal hemipelvectomy. In this study, a novel biomimetic hemipelvic prosthesis, including an artificial ilium, an artificial acetabulum, an...A pelvic endoprosthesis is the primary means of pelvic reconstruction after internal hemipelvectomy. In this study, a novel biomimetic hemipelvic prosthesis, including an artificial ilium, an artificial acetabulum, and an artificial pubis, was developed. A Finite Element Method （FEM） was carried out to investigate the biomechanical performance of a pelvis reconstructed with biomimetic hemipelvic prosthesis. Two models, including the reconstructed pelvis and the original pelvis （control model）, were established according to the geometry from CT data of a human male patient with pelvic bone sarcomas. The FE models predict that the biomeehanical function of the pelvic ring can be reestablished using this prosthesis. Results show that the body force loaded on the S 1 vertebra is restored and transferred towards the sacro-iliac joint, and along the ilium onto the bearing surface of the artificial ilium, then to the artificial acetabulum and pubis. Von Mises stresses observed in this reconstructed pelvis model are still within a low and elastic range below the yielding strength of cortical bone and Ti6A14V. The values of deformation and strain of the reconstructed pelvis are close to the data obtained in the original pelvis. With the partial replacement of the pubis, little influence is found towards the pubis symphysis. However, the interface between the prosthesis and pelvic bone may become the critical part of the reconstructed pelvis due to the discontinuity in the material properties, which results in stress shielding and deformation constraining. So a biomimetic flexible connection or inter layer to release the deformation of pelvis is suggested in future designing.展开更多
Forced oscillations(FOs), or low-frequency oscillations(LFOs) caused by periodic, continuous, small power disturbances, threaten the security and stability of power systems.Flexible AC transmission system(FACTS)device...Forced oscillations(FOs), or low-frequency oscillations(LFOs) caused by periodic, continuous, small power disturbances, threaten the security and stability of power systems.Flexible AC transmission system(FACTS)devices can effectively mitigate LFOs via stability control.We propose a novel method that mitigates FOs by shifting the resonant frequency.Based on the features of the linearized swing equation of a generator, a resonant frequency shift can be achieved by controlling the synchronous torque coefficient using a unified power flow controller(UPFC).Because of the resonance mechanism, the steady-state response of an FO can be effectively mitigated when the resonant frequency changes from the original one, which was close to the disturbance frequency.The principle is that a change in resonant frequency affects the resonance condition.Simulations are conducted in a single-machine infinite-bus(SMIB) system, and the simulation results verify that the method is straightforward to implement and can significantly mitigate FOs.The controller robustness when the resonant frequency is not accurately estimated is also analyzed in the simulations.展开更多
基金supported by the National Key Research and Development Program of China(2021YFF1201000,2022YFA1103700)the Quzhou Technology Projects(2022K46)+13 种基金the National Natural Science Foundation of China(Grant Nos.32121001,81921006,82125011,92149301,82361148131,82192863)the National Key Research and Development Program of China(2020YFA0804000,2020YFA0112200,the STI2030-Major Projects-2021ZD0202400,2021YFA1101000)the National Natural Science Foundation of China(Grant Nos.92168201,92049304,92049116,82122024,82071588,32000510,8236114813082271600,82322025,82330044,32341001)CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38010400)the Science and Technology Service Network Initiative of Chinese Academy of Sciences(KFJSTS-QYZD-2021-08-001)the Beijing Natural Science Foundation(Z230011,5242024)the Informatization Plan of Chinese Academy of Sciences(CAS-WX2021SF-0301,CAS-WX2022SDC-XK14,CAS-WX2021SF-0101)New Cormerstone Science Foundation through the XPLORER PRIZE(2021-1045)YouthInnovation Promotion Association of CAS(E1CAZW0401,2022083)Excellent Young Talents Program of Capital Medical University(12300927)the Project for Technology Development of Beijing-affliated Medical ResearchInstitutes(11000023T000002036310)ExcellentYoung Talents Training Program for the Construction of Beijing Municipal University Teacher Team(BPHR202203105)Young Elite Scientists Sponsorship Program by CAST(2021QNRC001)Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(JYY202X-X).
文摘Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation(DNAm)at specific CpG sites.However,a systematic comparison between DNA methylation data and other omics datasets has not yet been performed.Moreover,available DNAm age predictors are based on datasets with limited ethnic representation.To address these knowledge gaps,we generated and analyzed DNA methylation datasets from two independent Chinese cohorts,revealing age-related DNAm changes.Additionally,a DNA methylation aging clock(iCAS-DNAmAge)and a group of DNAm-based multi-modal clocks for Chinese individuals were developed,with most of them demonstrating strong predictive capabilities for chronological age.The clocks were further employed to predict factors influencing aging rates.The DNAm aging clock,derived from multi-modal aging features(compositeAge-DNAmAge),exhibited a close association with multi-omics changes,lifestyles,and disease status,underscoring its robust potential for precise biological age assessment.Our findings offer novel insights into the regulatory mechanism of age-related DNAm changes and extend the application of the DNAm clock for measuring biological age and aging pace,providing the basis for evaluating aging intervention strategies.
基金This research was supported by National Natural Science Foundation of China （No. 51205241）, the Re- search Fund for the Doctoral Program of Higher Educa- tion of China （20123108120008）, the Shanghai Mu- nicipal Education Commission, Shanghai Young Scien- tists Program （37010911004）, and the Innovation Fund of Shanghai University.
文摘A pelvic endoprosthesis is the primary means of pelvic reconstruction after internal hemipelvectomy. In this study, a novel biomimetic hemipelvic prosthesis, including an artificial ilium, an artificial acetabulum, and an artificial pubis, was developed. A Finite Element Method （FEM） was carried out to investigate the biomechanical performance of a pelvis reconstructed with biomimetic hemipelvic prosthesis. Two models, including the reconstructed pelvis and the original pelvis （control model）, were established according to the geometry from CT data of a human male patient with pelvic bone sarcomas. The FE models predict that the biomeehanical function of the pelvic ring can be reestablished using this prosthesis. Results show that the body force loaded on the S 1 vertebra is restored and transferred towards the sacro-iliac joint, and along the ilium onto the bearing surface of the artificial ilium, then to the artificial acetabulum and pubis. Von Mises stresses observed in this reconstructed pelvis model are still within a low and elastic range below the yielding strength of cortical bone and Ti6A14V. The values of deformation and strain of the reconstructed pelvis are close to the data obtained in the original pelvis. With the partial replacement of the pubis, little influence is found towards the pubis symphysis. However, the interface between the prosthesis and pelvic bone may become the critical part of the reconstructed pelvis due to the discontinuity in the material properties, which results in stress shielding and deformation constraining. So a biomimetic flexible connection or inter layer to release the deformation of pelvis is suggested in future designing.
基金supported by National Natural Science Foundation of China (No.51577032)State Grid Corporation of China (No.5210K017000C)
文摘Forced oscillations(FOs), or low-frequency oscillations(LFOs) caused by periodic, continuous, small power disturbances, threaten the security and stability of power systems.Flexible AC transmission system(FACTS)devices can effectively mitigate LFOs via stability control.We propose a novel method that mitigates FOs by shifting the resonant frequency.Based on the features of the linearized swing equation of a generator, a resonant frequency shift can be achieved by controlling the synchronous torque coefficient using a unified power flow controller(UPFC).Because of the resonance mechanism, the steady-state response of an FO can be effectively mitigated when the resonant frequency changes from the original one, which was close to the disturbance frequency.The principle is that a change in resonant frequency affects the resonance condition.Simulations are conducted in a single-machine infinite-bus(SMIB) system, and the simulation results verify that the method is straightforward to implement and can significantly mitigate FOs.The controller robustness when the resonant frequency is not accurately estimated is also analyzed in the simulations.
