目的比较五种心脏停搏液对心脏直视手术的未成熟心肌保护效果。方法随机将180例非紫绀型先天性心脏病患儿分成5组:HTK液组(A组)、改良St·Thomas液组(B组)、4∶1(自体血∶晶体)含自体血冷心脏停搏液组(C组)、1∶1(自体血∶晶体)含...目的比较五种心脏停搏液对心脏直视手术的未成熟心肌保护效果。方法随机将180例非紫绀型先天性心脏病患儿分成5组:HTK液组(A组)、改良St·Thomas液组(B组)、4∶1(自体血∶晶体)含自体血冷心脏停搏液组(C组)、1∶1(自体血∶晶体)含自体血冷心脏停搏液组(D组)和1∶4(自体血∶晶体)含自体血冷心脏停搏液组(E组)。五组患儿平均年龄(5.8±0.4)月,平均体重(6.1±0.3)kg。体外循环时间42~105(68.2±5.3)min,主动脉阻断21~68(38.4±4.6)min。对比分析体外循环前1 h及术后6 h、12 h及48 h肌钙蛋白I(cTnI)和磷酸肌酸酶同工酶(CKMB);术前及术后1 h、6 h左室射血分数(LVEF)。结果各组患儿体外循环前1 h及术后48 h cTnI及CKMB无显著性差异,术前及术后6 h LVEF均无统计学差异(P>0.05);HTK液组及1∶4含自体血冷心脏停搏液组术后6 h及12 h cTnI及CKMB较其他三组低,存在显著差异(P<0.05);HTK液组及1∶4含自体血冷心脏停搏液组术后1 h LVEF较其他三组高,存在显著差异(P<0.05)。结论 HTK液、1∶4含自体血冷心脏停搏液对未成熟心肌心肌保护作用较好。展开更多
BACKGROUND Neuronal intranuclear inclusion disease(NIID)is a rare neurological degenerative disorder with diverse manifestations and inadequate awareness.Only a few cases of NIID have been reported,and typical imaging...BACKGROUND Neuronal intranuclear inclusion disease(NIID)is a rare neurological degenerative disorder with diverse manifestations and inadequate awareness.Only a few cases of NIID have been reported,and typical imaging findings can provide certain clues for the diagnosis of the disease.Furthermore,skin biopsy and genetic testing are important to confirm the diagnosis.CASE SUMMARY An 84-year-old man presented to the Neurology Department of our hospital complaining of a progressive course of cognitive impairment and unsteady gait for 2 years.The symptoms gradually progressed and affected his daily life.The patient was initially diagnosed with Parkinson’s disease and vascular dementia.The patient did not respond to conventional treatment,such as dopasehydrazine.Therefore,magnetic resonance imaging(MRI)was performed.Based on the imaging findings,we suspected an NIID diagnosis.During the 3-year follow-up in our hospital,his clinical symptoms gradually progressed,and imaging findings became more significant.A high signal intensity along the corticomedullary junction persisted on MRI.Gene testing and skin biopsy were recommended in our hospital;however,the patient refused these procedures.NIID was also considered when he went to a superior hospital in Shanghai.The patient eventually agreed to undergo gene testing.This revealed abnormal GGC repeat expansions in the NOTCH2NLC gene.CONCLUSION The clinical manifestations of NIID are diverse.Patients with clinical manifestations similar to Parkinson’s disease and dementia may have NIID.展开更多
文摘目的比较五种心脏停搏液对心脏直视手术的未成熟心肌保护效果。方法随机将180例非紫绀型先天性心脏病患儿分成5组:HTK液组(A组)、改良St·Thomas液组(B组)、4∶1(自体血∶晶体)含自体血冷心脏停搏液组(C组)、1∶1(自体血∶晶体)含自体血冷心脏停搏液组(D组)和1∶4(自体血∶晶体)含自体血冷心脏停搏液组(E组)。五组患儿平均年龄(5.8±0.4)月,平均体重(6.1±0.3)kg。体外循环时间42~105(68.2±5.3)min,主动脉阻断21~68(38.4±4.6)min。对比分析体外循环前1 h及术后6 h、12 h及48 h肌钙蛋白I(cTnI)和磷酸肌酸酶同工酶(CKMB);术前及术后1 h、6 h左室射血分数(LVEF)。结果各组患儿体外循环前1 h及术后48 h cTnI及CKMB无显著性差异,术前及术后6 h LVEF均无统计学差异(P>0.05);HTK液组及1∶4含自体血冷心脏停搏液组术后6 h及12 h cTnI及CKMB较其他三组低,存在显著差异(P<0.05);HTK液组及1∶4含自体血冷心脏停搏液组术后1 h LVEF较其他三组高,存在显著差异(P<0.05)。结论 HTK液、1∶4含自体血冷心脏停搏液对未成熟心肌心肌保护作用较好。
文摘BACKGROUND Neuronal intranuclear inclusion disease(NIID)is a rare neurological degenerative disorder with diverse manifestations and inadequate awareness.Only a few cases of NIID have been reported,and typical imaging findings can provide certain clues for the diagnosis of the disease.Furthermore,skin biopsy and genetic testing are important to confirm the diagnosis.CASE SUMMARY An 84-year-old man presented to the Neurology Department of our hospital complaining of a progressive course of cognitive impairment and unsteady gait for 2 years.The symptoms gradually progressed and affected his daily life.The patient was initially diagnosed with Parkinson’s disease and vascular dementia.The patient did not respond to conventional treatment,such as dopasehydrazine.Therefore,magnetic resonance imaging(MRI)was performed.Based on the imaging findings,we suspected an NIID diagnosis.During the 3-year follow-up in our hospital,his clinical symptoms gradually progressed,and imaging findings became more significant.A high signal intensity along the corticomedullary junction persisted on MRI.Gene testing and skin biopsy were recommended in our hospital;however,the patient refused these procedures.NIID was also considered when he went to a superior hospital in Shanghai.The patient eventually agreed to undergo gene testing.This revealed abnormal GGC repeat expansions in the NOTCH2NLC gene.CONCLUSION The clinical manifestations of NIID are diverse.Patients with clinical manifestations similar to Parkinson’s disease and dementia may have NIID.
