Objective： Ethanol treatment induces an increase in oxidative stress. As licorice compounds are potent antioxidants, our aim was to examine whether magnesium isoglycyrrhizinate attenuated lipid peroxidation, the majo...Objective： Ethanol treatment induces an increase in oxidative stress. As licorice compounds are potent antioxidants, our aim was to examine whether magnesium isoglycyrrhizinate attenuated lipid peroxidation, the major end-point of oxidative damage resulting from ethanol administration. Methods： Four groups（18 animals in each group） of male Kunming mice were used. The first group served as control and received 0.4 ml normal saline daily for 18 days orally. The second group of mice was given 56% ethanol at 16 ml/kg body weight per day for 18 days orally. The third group was given the same dose of ethanol and administrated magnesium isoglycyrrhizinate （15 mg/kg.d, i.p.） for 18 days. The fourth group was given the same dose of ethanol and administrated with magnesium isoglycyrrhizinate （45 mg/kg.d, i.p.） for 18 days. Twenty four hours after 9 days or 18 days of treatment the mice were sacrificed using 10% chloral hydrate. Sperm counts and motility in the epididymis were assessed. The lipid peroxidation and antioxidants of testicular mitochondria were also determined. The pathological changes of testicle tissue of the mice were observed by light microscopy. Results： Magnesium isoglycyrrhizinate effectively prevented the ethanol-induced seminiferous epithelium disorganization and degeneration of Sertoli cells and germ cells. Sperm counts and motility of the magnesium isoglycyrrhizinate treated groups were higher than those of the alcohol treated group, but were lower than those of the control group. The drug exhibited an ability to counteract ethanol induced oxidative challenge as it effectively reduced testicular malondialdehyde （MDA） and increased the activities of superoxide dismutase and glutathione peroxidase. Conclusion： Magnesium isoglycyrrhizinate is able to inhibit the ethanol-induced lipid peroxidation and has a protective effect against testicular oxidative injury.展开更多
The Lower Triassic at Majiashan Section, deposited in the deep part of the Lower Yangtze carbonate ramp, is the only outcrop of the deep Lower Triassic preserved in the present Lower Yangtze region. Even so, the alt...The Lower Triassic at Majiashan Section, deposited in the deep part of the Lower Yangtze carbonate ramp, is the only outcrop of the deep Lower Triassic preserved in the present Lower Yangtze region. Even so, the alternations of mudrock of mudrock and marl (or limestone) are still very distinct and recognizableable, though usually more or less condensed. The lithological and geochemical cycles at Majiashan Section are discussed in terms of the sedimentary characters and the contents of some elements analyzed at a 2-centimeter-interval with no hiatus of the Lower Triassic. The division resolution of the Griesbachian stratigraphy may increase to the scale of ten thousand years by the mudrock-marl (or limestone) bundles and the geochemical cycles. The analysis of the relationship between the sedimentary cycles/the geochemical cycles and the Milankovitch cycles may suggest the time limit and the sedimentary rates.展开更多
Over the last few decades,the research on the effect of bristle pack position on the rotordynamic characteristics of the brush-labyrinth seals is not sufficient.To this end,two kinds of brush-labyrinth seals for the b...Over the last few decades,the research on the effect of bristle pack position on the rotordynamic characteristics of the brush-labyrinth seals is not sufficient.To this end,two kinds of brush-labyrinth seals for the bristle pack element installed upstream of the labyrinth teeth named BSU and installed downstream of the labyrinth teeth called BSD were used to investigate the effect of bristle pack position on the rotordynamic characteristics of the brush-labyrinth seals.Using the numerical model combining the porous medium model and the whirling rotor method,the rotordynamic characteristics of the BSU and BSD at various operating conditions including four kinds of pressure ratios,five kinds of inlet preswirl speeds and four kinds of rotor spinning speeds were conducted.The obtained results show that the effects of operating conditions on rotordynamic coefficients for the different seal configurations are different.The direct stiffness,cross-coupled stiffness and direct damping of the BSU are lower than those of the BSD.The rotordynamic coefficients of the BSU are more insensitive to the operating conditions variation.From the perspective of the seal stability,the BSU is a better brush-labyrinth seal configuration at high pressure ratio,high positive preswirl or high rotor spinning speed conditions.While in the case of low pressure ratio,low positive preswirl or low rotor spinning speed conditions,the BSD is a better choice.展开更多
There is no doubt about the potential technological significance of nanofluids. The promising application areas have been identified as effective heat transfer fluids, contrast agents in magnetic resonance imaging, ma...There is no doubt about the potential technological significance of nanofluids. The promising application areas have been identified as effective heat transfer fluids, contrast agents in magnetic resonance imaging, magnetohyperthermia treatment, precursors to high performance nanocomposites and ordered nanostructures. However, commercial applications are rare, in part due to the limited understanding of the nanofluid fundamentals such as colloid stability, phase diagrams and rheology. This paper intends to provide a brief overview of the scientific disciplines that are important to nanofluids, and the interconnection among different disciplines in order to gain a perspective on the future development of this intriguing area.展开更多
The continuous development of robot technology has made phenotype detection robots a key for extracting and analyzing phenotyping data in agriculture and forestry.The different applications of agricultural robots and ...The continuous development of robot technology has made phenotype detection robots a key for extracting and analyzing phenotyping data in agriculture and forestry.The different applications of agricultural robots and phenotype detection robots were discussed in this article.Further,the structural characteristics and information interaction modes of the current phenotype detection robots were summarized from the viewpoint of agriculture and forestry.The publications with keywords related to clustering distribution were analyzed and the currently available phenotype robots were classified.Additionally,a conclusion on the design criteria and evaluation system of plant phenotype detection robots was summarized and obtained,and the challenges and future development direction were proposed,which can provide a reference for the design and applications of agriculture and forestry robots.展开更多
In order to address the challenge of non-destructive detection of tomato fruit ripeness in controlled environments,this study proposed a real-time instance segmentation method based on the edge device.This method comb...In order to address the challenge of non-destructive detection of tomato fruit ripeness in controlled environments,this study proposed a real-time instance segmentation method based on the edge device.This method combined the principles of phenotype robots and machine vision based on deep learning.A compact and remotely controllable phenotype detection robot was employed to acquire precise data on tomato ripeness.The video data were then processed by using an efficient backbone and the FeatFlowNet structure for feature extraction and analysis of key-frame to non-key-frame mapping from video data.To enhance the diversity of training datasets and the generalization of the model,an innovative approach was chosen by using random enhancement techniques.Besides,the PolyLoss optimization technique was applied to further improve the accuracy of the ripeness multi-class detection tasks.Through validation,the method of this study achieved real-time processing speeds of 90.1 fps(RTX 3070Ti)and 65.5 fps(RTX 2060 S),with an average detection accuracy of 97%compared to manually measured results.This is more accurate and efficient than other instance segmentation models according to actual testing in a greenhouse.Therefore,the results of this research can be deployed in edge devices and provide technical support for unmanned greenhouse monitoring devices or fruit-picking robots in facility environments.展开更多
Summary What is already known on this topic?The average secondhand smoke exposure rate was 68.1%in China in 2018.The World Health Organization suggests that legislation must be used to achieve a 100%smoke-free environ...Summary What is already known on this topic?The average secondhand smoke exposure rate was 68.1%in China in 2018.The World Health Organization suggests that legislation must be used to achieve a 100%smoke-free environment and protect nonsmokers from secondhand smoke.What is added by this report?展开更多
The Permian Triassic boundary (PTB) and the lowest Triassic in the Yangtze region are considered to be the sediments of dysaeroxic and even anoxic environments, due to the dark thin bedded fine deposits, the highly ...The Permian Triassic boundary (PTB) and the lowest Triassic in the Yangtze region are considered to be the sediments of dysaeroxic and even anoxic environments, due to the dark thin bedded fine deposits, the highly developed parallel beddings with pyrites, the suppression of bio disturbance, and the monotonous fossils. However, the trace fossils there show a rather weak effect of the anoxic event. Meanwhile, the high resolution geochemical data are analyzed with 2 cm interval in the PTB and the lowest Triassic at the Majiashan Section, Chaohu, Anhui Province. The results show that the water depth of Chaohu region in the earliest Triassic was shallow, which might be a feature of the neritic environment. The high resolution geochemical proxies for anoxia have some contrary results. The geochemical data often indicate the dysaeroxic and even anoxic environments during that time, whereas other proxies (such as w (V)/ w (Cr), w (Ni)/ w (Co)) denote that they are normal marine sediments.展开更多
A cDNA, designated as rtSH3p13, was isolated from a rat testis cDNA library. It consists of 1463 bp nuclear acids,which encodes a protein of 312 amino acids and was assigned the GenBank accession number AF227439. The ...A cDNA, designated as rtSH3p13, was isolated from a rat testis cDNA library. It consists of 1463 bp nuclear acids,which encodes a protein of 312 amino acids and was assigned the GenBank accession number AF227439. The deduced rtSH3p13 protein is a truncated isoform of SH3p13 as a result of mRNA alternative splicing. It is mainly expressed in the rat testis, detected in spermatids at the steps 8-19 of spermiogenesis, and found around the acrosome. During postnatal development, rtSH3p13 appears on day 18 and reaches maximum on day 60. Further experimental results suggested that rtSH3p13 forms a complex with activated epidermal growth factor receptor (EGFR) and interacts with synaptojanin I. Surprisingly, similar to SH3 domain, the V region of rtSH3p13 also inhibits endocytosis in CHO cells.Our results reveal a link between an rtSH3p13-synaptojanin-clathrin complex-mediated formation of pits and the process of spermiogenesis.展开更多
The Permian-Triassic Boundary Stratigraphic Set (PTBST), characteristic of the GSSP section of Meishan and widespread in marine Permian-Triassic Boundary (PTB) sequences of South China, is used to trace and recognize ...The Permian-Triassic Boundary Stratigraphic Set (PTBST), characteristic of the GSSP section of Meishan and widespread in marine Permian-Triassic Boundary (PTB) sequences of South China, is used to trace and recognize the PTB in a continental sequence at Chahe (Beds 66f―68c). Diversified Permian plant fossils extended to the PTBST, and a few relicts survived above that level. Sporomorphs are dominated by fern spores of Permian nature below the PTBST, above which they are replaced by gymnosperm pollen of Triassic aspect. In the nearby Zhejue Section, the continental PTBST is charac- terized by the fungal 'spike' recorded in many places throughout the world. The boundary claybeds (66f and 68a,c) of the PTBST are composed of mixed illite-montmorillonite layers analogous with those at Meishan. They contain volcanogenic minerals such as β quartz and zircon. U/Pb dating of the upper claybed gives ages of 247.5 and 252.6 Ma for Beds 68a and 68c respectively, averaging 250 Ma. In con- trast to the situation in Xinjiang and South Africa, the sediment sequence of the Permian-Triassic tran- sition in the Chahe section (Beds 56―80) become finer upward. Shallowing and coarsening upward is not, therefore, characteristic of the Permian-Triassic transition everywhere. The occurrence of relicts of the Gigantopteris Flora in the Kayitou Fm. indicates that, unlike most marine biota, relicts of this pa- leophytic flora survived into the earliest Triassic. It is concluded that Bed 67 at Chahe corresponds to Bed 27 at Meishan, and that the PTB should be put within the 60-cm-thick Bed 67b④, now put at its base tentatively. This is the most accurate correlation of the PTB in continental facies with that in the marine GSSP.展开更多
文摘Objective： Ethanol treatment induces an increase in oxidative stress. As licorice compounds are potent antioxidants, our aim was to examine whether magnesium isoglycyrrhizinate attenuated lipid peroxidation, the major end-point of oxidative damage resulting from ethanol administration. Methods： Four groups（18 animals in each group） of male Kunming mice were used. The first group served as control and received 0.4 ml normal saline daily for 18 days orally. The second group of mice was given 56% ethanol at 16 ml/kg body weight per day for 18 days orally. The third group was given the same dose of ethanol and administrated magnesium isoglycyrrhizinate （15 mg/kg.d, i.p.） for 18 days. The fourth group was given the same dose of ethanol and administrated with magnesium isoglycyrrhizinate （45 mg/kg.d, i.p.） for 18 days. Twenty four hours after 9 days or 18 days of treatment the mice were sacrificed using 10% chloral hydrate. Sperm counts and motility in the epididymis were assessed. The lipid peroxidation and antioxidants of testicular mitochondria were also determined. The pathological changes of testicle tissue of the mice were observed by light microscopy. Results： Magnesium isoglycyrrhizinate effectively prevented the ethanol-induced seminiferous epithelium disorganization and degeneration of Sertoli cells and germ cells. Sperm counts and motility of the magnesium isoglycyrrhizinate treated groups were higher than those of the alcohol treated group, but were lower than those of the control group. The drug exhibited an ability to counteract ethanol induced oxidative challenge as it effectively reduced testicular malondialdehyde （MDA） and increased the activities of superoxide dismutase and glutathione peroxidase. Conclusion： Magnesium isoglycyrrhizinate is able to inhibit the ethanol-induced lipid peroxidation and has a protective effect against testicular oxidative injury.
基金the National Natural Science Founda-tion of China (No. 49632070).
文摘The Lower Triassic at Majiashan Section, deposited in the deep part of the Lower Yangtze carbonate ramp, is the only outcrop of the deep Lower Triassic preserved in the present Lower Yangtze region. Even so, the alternations of mudrock of mudrock and marl (or limestone) are still very distinct and recognizableable, though usually more or less condensed. The lithological and geochemical cycles at Majiashan Section are discussed in terms of the sedimentary characters and the contents of some elements analyzed at a 2-centimeter-interval with no hiatus of the Lower Triassic. The division resolution of the Griesbachian stratigraphy may increase to the scale of ten thousand years by the mudrock-marl (or limestone) bundles and the geochemical cycles. The analysis of the relationship between the sedimentary cycles/the geochemical cycles and the Milankovitch cycles may suggest the time limit and the sedimentary rates.
基金co-supported by the National Key R&D Program of China(No.2017YFB0601804)the National Natural Science Foundation of China(No.51776152)。
文摘Over the last few decades,the research on the effect of bristle pack position on the rotordynamic characteristics of the brush-labyrinth seals is not sufficient.To this end,two kinds of brush-labyrinth seals for the bristle pack element installed upstream of the labyrinth teeth named BSU and installed downstream of the labyrinth teeth called BSD were used to investigate the effect of bristle pack position on the rotordynamic characteristics of the brush-labyrinth seals.Using the numerical model combining the porous medium model and the whirling rotor method,the rotordynamic characteristics of the BSU and BSD at various operating conditions including four kinds of pressure ratios,five kinds of inlet preswirl speeds and four kinds of rotor spinning speeds were conducted.The obtained results show that the effects of operating conditions on rotordynamic coefficients for the different seal configurations are different.The direct stiffness,cross-coupled stiffness and direct damping of the BSU are lower than those of the BSD.The rotordynamic coefficients of the BSU are more insensitive to the operating conditions variation.From the perspective of the seal stability,the BSU is a better brush-labyrinth seal configuration at high pressure ratio,high positive preswirl or high rotor spinning speed conditions.While in the case of low pressure ratio,low positive preswirl or low rotor spinning speed conditions,the BSD is a better choice.
基金The Dow Chemical Companyfor its support of the writing of this manuscript
文摘There is no doubt about the potential technological significance of nanofluids. The promising application areas have been identified as effective heat transfer fluids, contrast agents in magnetic resonance imaging, magnetohyperthermia treatment, precursors to high performance nanocomposites and ordered nanostructures. However, commercial applications are rare, in part due to the limited understanding of the nanofluid fundamentals such as colloid stability, phase diagrams and rheology. This paper intends to provide a brief overview of the scientific disciplines that are important to nanofluids, and the interconnection among different disciplines in order to gain a perspective on the future development of this intriguing area.
基金funded by the Construction of Collaborative Innovation Center of Beijing Academy of Agricultural and Forestry Sciences(KJCX201917)Beijing Nova Program(Z211100002121065)Science and Technology Innovation Special Construction Funded Program of Beijing Academy of Agriculture and Forestry Sciences(KJCX20210413).
文摘The continuous development of robot technology has made phenotype detection robots a key for extracting and analyzing phenotyping data in agriculture and forestry.The different applications of agricultural robots and phenotype detection robots were discussed in this article.Further,the structural characteristics and information interaction modes of the current phenotype detection robots were summarized from the viewpoint of agriculture and forestry.The publications with keywords related to clustering distribution were analyzed and the currently available phenotype robots were classified.Additionally,a conclusion on the design criteria and evaluation system of plant phenotype detection robots was summarized and obtained,and the challenges and future development direction were proposed,which can provide a reference for the design and applications of agriculture and forestry robots.
基金funded by the National Key R&D Program(Grant No.2022YFD2002305)Beijing Nova Program(Grant No.Z211100002121065,20220484202)Collaborative Innovation Center of Beijing Academy of Agricultural and Forestry Sciences(Grant No.KJCX201917).
文摘In order to address the challenge of non-destructive detection of tomato fruit ripeness in controlled environments,this study proposed a real-time instance segmentation method based on the edge device.This method combined the principles of phenotype robots and machine vision based on deep learning.A compact and remotely controllable phenotype detection robot was employed to acquire precise data on tomato ripeness.The video data were then processed by using an efficient backbone and the FeatFlowNet structure for feature extraction and analysis of key-frame to non-key-frame mapping from video data.To enhance the diversity of training datasets and the generalization of the model,an innovative approach was chosen by using random enhancement techniques.Besides,the PolyLoss optimization technique was applied to further improve the accuracy of the ripeness multi-class detection tasks.Through validation,the method of this study achieved real-time processing speeds of 90.1 fps(RTX 3070Ti)and 65.5 fps(RTX 2060 S),with an average detection accuracy of 97%compared to manually measured results.This is more accurate and efficient than other instance segmentation models according to actual testing in a greenhouse.Therefore,the results of this research can be deployed in edge devices and provide technical support for unmanned greenhouse monitoring devices or fruit-picking robots in facility environments.
文摘Summary What is already known on this topic?The average secondhand smoke exposure rate was 68.1%in China in 2018.The World Health Organization suggests that legislation must be used to achieve a 100%smoke-free environment and protect nonsmokers from secondhand smoke.What is added by this report?
基金The study is supported by the National Natural Science Foundation of China( No.4963 2 0 70 )
文摘The Permian Triassic boundary (PTB) and the lowest Triassic in the Yangtze region are considered to be the sediments of dysaeroxic and even anoxic environments, due to the dark thin bedded fine deposits, the highly developed parallel beddings with pyrites, the suppression of bio disturbance, and the monotonous fossils. However, the trace fossils there show a rather weak effect of the anoxic event. Meanwhile, the high resolution geochemical data are analyzed with 2 cm interval in the PTB and the lowest Triassic at the Majiashan Section, Chaohu, Anhui Province. The results show that the water depth of Chaohu region in the earliest Triassic was shallow, which might be a feature of the neritic environment. The high resolution geochemical proxies for anoxia have some contrary results. The geochemical data often indicate the dysaeroxic and even anoxic environments during that time, whereas other proxies (such as w (V)/ w (Cr), w (Ni)/ w (Co)) denote that they are normal marine sediments.
基金This study was supported by grants from National Natural Science Foundation of China(No.30240019,30300060)National High Technology Research and Development Program of China(No.2001 AA221I31)+1 种基金Major State Basic Research Project(No.Gl 999055901)State Ministry of Science and Technology Program(No.2002BA7llA0l).
文摘A cDNA, designated as rtSH3p13, was isolated from a rat testis cDNA library. It consists of 1463 bp nuclear acids,which encodes a protein of 312 amino acids and was assigned the GenBank accession number AF227439. The deduced rtSH3p13 protein is a truncated isoform of SH3p13 as a result of mRNA alternative splicing. It is mainly expressed in the rat testis, detected in spermatids at the steps 8-19 of spermiogenesis, and found around the acrosome. During postnatal development, rtSH3p13 appears on day 18 and reaches maximum on day 60. Further experimental results suggested that rtSH3p13 forms a complex with activated epidermal growth factor receptor (EGFR) and interacts with synaptojanin I. Surprisingly, similar to SH3 domain, the V region of rtSH3p13 also inhibits endocytosis in CHO cells.Our results reveal a link between an rtSH3p13-synaptojanin-clathrin complex-mediated formation of pits and the process of spermiogenesis.
基金Supported by of the National Natural Science Foundation of China (Grant Nos. 40172012 and 40232025)partly by the Geological Survey of China and the Chinese National Committee on Stratigraphy
文摘The Permian-Triassic Boundary Stratigraphic Set (PTBST), characteristic of the GSSP section of Meishan and widespread in marine Permian-Triassic Boundary (PTB) sequences of South China, is used to trace and recognize the PTB in a continental sequence at Chahe (Beds 66f―68c). Diversified Permian plant fossils extended to the PTBST, and a few relicts survived above that level. Sporomorphs are dominated by fern spores of Permian nature below the PTBST, above which they are replaced by gymnosperm pollen of Triassic aspect. In the nearby Zhejue Section, the continental PTBST is charac- terized by the fungal 'spike' recorded in many places throughout the world. The boundary claybeds (66f and 68a,c) of the PTBST are composed of mixed illite-montmorillonite layers analogous with those at Meishan. They contain volcanogenic minerals such as β quartz and zircon. U/Pb dating of the upper claybed gives ages of 247.5 and 252.6 Ma for Beds 68a and 68c respectively, averaging 250 Ma. In con- trast to the situation in Xinjiang and South Africa, the sediment sequence of the Permian-Triassic tran- sition in the Chahe section (Beds 56―80) become finer upward. Shallowing and coarsening upward is not, therefore, characteristic of the Permian-Triassic transition everywhere. The occurrence of relicts of the Gigantopteris Flora in the Kayitou Fm. indicates that, unlike most marine biota, relicts of this pa- leophytic flora survived into the earliest Triassic. It is concluded that Bed 67 at Chahe corresponds to Bed 27 at Meishan, and that the PTB should be put within the 60-cm-thick Bed 67b④, now put at its base tentatively. This is the most accurate correlation of the PTB in continental facies with that in the marine GSSP.
