Prostate-specific membrane antigen (PSMA) is a cellsurface glycoprotein expressed predominantly in prostatesecretory acinar epithelium and prostate cancer cells aswell as in several extraprostatic tissues. Mouse monoc...Prostate-specific membrane antigen (PSMA) is a cellsurface glycoprotein expressed predominantly in prostatesecretory acinar epithelium and prostate cancer cells aswell as in several extraprostatic tissues. Mouse monoclonal antibody 4G5 specific to the extracellular domainof PSMA was used to screen two phage displayed peptide libraries (9aa linear and 9aa cys library). Three 4G5reactive phagotopes were identified. Sequence analysis ofisolated clones demonstrated that the interaction motif'VDPA/SK' has high homology to 719-725aa on PSMA.Immunohistochemical staming of the prostate cancer sam ple with the PSMA-mimic phagotope (mimotope) immunized serum antibodies demonstrate that the mimotopeisolated from the phage displayed peptide libraries can induce PSMA specific immune response in vivo.展开更多
This study explores the influence of social media on stock volatility and builds a feature model with an intelligence algorithm using social media data from Xueqiu.com in China, Sina Finance and Economics, Sina Microb...This study explores the influence of social media on stock volatility and builds a feature model with an intelligence algorithm using social media data from Xueqiu.com in China, Sina Finance and Economics, Sina Microblog, and Oriental Fortune. We find that the effect of social factors, such as increased attention to a stock's volatility, is more significant than public sentiment. A prediction model is introduced based on social factors and public sentiment to predict stock volatility. Our findings indicate that the influence of social media data on the next day's volatility is more significant but declines over time.展开更多
AIM To investigate the feasibility of preoperative docetaxel,cisplatin and capecitabine(DCC) in patients with resectable gastric cancer.METHODS Patients with resectable gastric cancer fulfilling the inclusion criteria...AIM To investigate the feasibility of preoperative docetaxel,cisplatin and capecitabine(DCC) in patients with resectable gastric cancer.METHODS Patients with resectable gastric cancer fulfilling the inclusion criteria,were treated with 4 cycles of docetaxel(60 mg/m2),cisplatin(60 mg/m2) and capecitabine(1.875 mg/m2 orally on day 1-14,two daily doses) repeated every three weeks,followed by surgery.Primary end point was the feasibility and toxicity/safety profile of DCC,secondary endpoints were pathological complete resection rate and pathological complete response(p CR) rate.RESULTS All of the patients(51) were assessable for the feasibility and safety of the regimen.The entire preoperative regimen was completed by 68.6% of the patients.Grade Ⅲ/Ⅳ febrile neutropenia occurred in 10% of all courses.Three patients died due to treatment related toxicity(5.9%),one of them(also) because of refusing further treatment for toxicity.Of the 45 patients who were evaluable for secondary endpoints,four developed metastatic disease and 76.5% received a curative resection.In 3 patients a p CR was seen(5.9%),two patients underwent a R1 resection(3.9%).CONCLUSION Four courses of DCC as a preoperative regimen for patients with primarily resectable gastric cancer is highly demanding.The high occurrence of febrile neutropenia is of concern.To decrease the occurrence of febrile neutropenia the prophylactic use of granulocyte colonystimulating factor(G-CSF) should be explored.A curative resection rate of 76.5% is acceptable.The use of DCC without G-CSF support as preoperative regimen in resectable gastric cancer is debatable.展开更多
"世上最令人过目不忘的风景,是每个人的脸。而每个人脸上的细微表情又是难以捉摸与揣测的。"在刚刚落下帷幕的2020春夏上海国际时装周上,独立设计师品牌YES BY YESIR新一季的主题就是"脸(Face)"。脸与时装是一致的..."世上最令人过目不忘的风景,是每个人的脸。而每个人脸上的细微表情又是难以捉摸与揣测的。"在刚刚落下帷幕的2020春夏上海国际时装周上,独立设计师品牌YES BY YESIR新一季的主题就是"脸(Face)"。脸与时装是一致的,一个人的喜怒哀乐既体现在面部表情中,也会在其穿衣打扮中有所体现。在YES BY YESIR2020春夏时装发布会上,看似简单直接的灵感元素,其实是不同时代对"脸"的多元解读:情绪起伏的喜怒哀乐、欲说还休的心口不一、面不改色的内心澎湃、面具之下的另一张脸等。展开更多
文摘Prostate-specific membrane antigen (PSMA) is a cellsurface glycoprotein expressed predominantly in prostatesecretory acinar epithelium and prostate cancer cells aswell as in several extraprostatic tissues. Mouse monoclonal antibody 4G5 specific to the extracellular domainof PSMA was used to screen two phage displayed peptide libraries (9aa linear and 9aa cys library). Three 4G5reactive phagotopes were identified. Sequence analysis ofisolated clones demonstrated that the interaction motif'VDPA/SK' has high homology to 719-725aa on PSMA.Immunohistochemical staming of the prostate cancer sam ple with the PSMA-mimic phagotope (mimotope) immunized serum antibodies demonstrate that the mimotopeisolated from the phage displayed peptide libraries can induce PSMA specific immune response in vivo.
基金supported by National Natural Science Foundation of China (Grant No. 71532004)
文摘This study explores the influence of social media on stock volatility and builds a feature model with an intelligence algorithm using social media data from Xueqiu.com in China, Sina Finance and Economics, Sina Microblog, and Oriental Fortune. We find that the effect of social factors, such as increased attention to a stock's volatility, is more significant than public sentiment. A prediction model is introduced based on social factors and public sentiment to predict stock volatility. Our findings indicate that the influence of social media data on the next day's volatility is more significant but declines over time.
文摘AIM To investigate the feasibility of preoperative docetaxel,cisplatin and capecitabine(DCC) in patients with resectable gastric cancer.METHODS Patients with resectable gastric cancer fulfilling the inclusion criteria,were treated with 4 cycles of docetaxel(60 mg/m2),cisplatin(60 mg/m2) and capecitabine(1.875 mg/m2 orally on day 1-14,two daily doses) repeated every three weeks,followed by surgery.Primary end point was the feasibility and toxicity/safety profile of DCC,secondary endpoints were pathological complete resection rate and pathological complete response(p CR) rate.RESULTS All of the patients(51) were assessable for the feasibility and safety of the regimen.The entire preoperative regimen was completed by 68.6% of the patients.Grade Ⅲ/Ⅳ febrile neutropenia occurred in 10% of all courses.Three patients died due to treatment related toxicity(5.9%),one of them(also) because of refusing further treatment for toxicity.Of the 45 patients who were evaluable for secondary endpoints,four developed metastatic disease and 76.5% received a curative resection.In 3 patients a p CR was seen(5.9%),two patients underwent a R1 resection(3.9%).CONCLUSION Four courses of DCC as a preoperative regimen for patients with primarily resectable gastric cancer is highly demanding.The high occurrence of febrile neutropenia is of concern.To decrease the occurrence of febrile neutropenia the prophylactic use of granulocyte colonystimulating factor(G-CSF) should be explored.A curative resection rate of 76.5% is acceptable.The use of DCC without G-CSF support as preoperative regimen in resectable gastric cancer is debatable.
文摘"世上最令人过目不忘的风景,是每个人的脸。而每个人脸上的细微表情又是难以捉摸与揣测的。"在刚刚落下帷幕的2020春夏上海国际时装周上,独立设计师品牌YES BY YESIR新一季的主题就是"脸(Face)"。脸与时装是一致的,一个人的喜怒哀乐既体现在面部表情中,也会在其穿衣打扮中有所体现。在YES BY YESIR2020春夏时装发布会上,看似简单直接的灵感元素,其实是不同时代对"脸"的多元解读:情绪起伏的喜怒哀乐、欲说还休的心口不一、面不改色的内心澎湃、面具之下的另一张脸等。
