Advanced driver-assistance systems such as Honda’s collision mitigation brake system(CMBS)can help achieve traffic safety.In this paper,the naturalistic driving study and a series of simulations are combined to bette...Advanced driver-assistance systems such as Honda’s collision mitigation brake system(CMBS)can help achieve traffic safety.In this paper,the naturalistic driving study and a series of simulations are combined to better evaluate the performance of the CMBS in the Chinese traffic environment.First,because safety-critical situations can be diverse especially in the Chinese environment,the Chinese traffic-accident characteristics are analyzed according to accident statistics over the past 17 years.Next,10 Chinese traffic-accident scenarios accounting for more than 80%of traffic accidents are selected.For each typical scenario,353 representative cases are collected from the traffic-management department of Beijing.These real-world accident cases are then reconstructed by the traffic-accident-reconstruction software PC-Crash on the basis of accident-scene diagrams.This study also proposes a systematic analytical process for estimating the effectiveness of the technology using the co-simulation platform of PC-Crash and rateEFFECT,in which 176 simulations are analyzed in detail to assess the accident-avoidance performance of the CMBS.The overall collision-avoidance effectiveness reaches 82.4%,showing that the proposed approach is efficient for avoiding collisions,thereby enhancing traffic safety and improving traffic management.展开更多
Background:Babesiosis is an uncommon but emerging tick-borne disease caused by the genus Babesia.In this case study,we report a case of human infection with a novel Babesia sp.in China.Findings:The patient in question...Background:Babesiosis is an uncommon but emerging tick-borne disease caused by the genus Babesia.In this case study,we report a case of human infection with a novel Babesia sp.in China.Findings:The patient in question had been suffering from repetitive occurrences of mild fever of unknown origin and fatigue for 10 years.Ring forms,tetrads,and one or two dots of chromatin or trophozoite-like organisms were observed in the patient’s thin blood smears and bone marrow smears.Using a confocal laser-scanning microscope,it was observed that the patient’s serum had reactivity with the surface proteins of the B.microti strain.Electron microscopy revealed oval red blood cells with 1~2μm of knob protrusions in the cellular membrane.The results of the Babesia-specific nested PCR assay for 18S rRNA confirmed the presence of Babesia infection.The construction of a phylogenetic relationship showed clustering with B.microti and B.duncani,which was identified as a novel Babesia species and named as Babesia sp.XXB/HangZhou.Azithromycin,doxycycline,and moxifloxacin hydrochloride were shown to relieve symptoms but were not as effective after continuous usage.After atovaquone(Mepron®)administration,the patient recovered from fever and tested negative for detection of Babesia-specific genes.Conclusion:Babesia sp.XXB/HangZhou is a novel Babesia species,which causes mild babesiosis in an immunocompetent patient.展开更多
Background:Primary pulmonary amoeba is very rare and here we report a case of a 68-year-old man presenting with primary pulmonary amoeba after undergoing chemotherapy for lung adenocarcinoma.Case presentation:In Octob...Background:Primary pulmonary amoeba is very rare and here we report a case of a 68-year-old man presenting with primary pulmonary amoeba after undergoing chemotherapy for lung adenocarcinoma.Case presentation:In October 2016,the man aged 68 was admitted to our hospital because of repeated cough for 8 months and hemoptysis for 1 month.He was diagnosed lung adenocarcinoma and underwent surgery in 2012 without receiving chemotherapy.In March 2016,the patients suffered recurrence of cancer and was treated with chemotherapy.After 2 months of chemotherapy,the patient had consistent cough with white sputum,and chest CT showed a local lung nodule.The physicians suspected that the patient had pulmonary infectious diseases,and he was treated with empirical antibacterial treatment.However,his symptom wasn’t relieved and later the percutaneous lung biopsy found trophozites of Entamoeba histolytica.After administration of metronidazole,the symptoms of the patient were markedly relieved and the lesions were absorbed.Conclusions:In such cases where patients with pulmonary nodules were in immunodeficiency state and had adequate but ineffective anti-bacterial treatment,Entamoeba histolytica infection could be one of the rare causes.Percutaneous lung biopsy should be recommended and specific dying for parasites should be done when necessary.展开更多
基金supported by the Natural Science Foundation of Shanxi(20210302123002)Technical Research and Development Project from Lu'an Chemical Industry Group Co.,Ltd.(2021A0105005)the Foundation of State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering(2022-K20).
基金Project(51625503) supported by the National Science Fund for Distinguished Young Scholars,ChinaProject(61790561) supported by the National Natural Science Foundation of China+1 种基金Project(20163000124) supported by Tsinghua-Honda Joint Research,ChinaProject(TTS2017-02) supported by the Open Fund for Jiangsu Key Laboratory of Traffic and Transportation Security,China
文摘Advanced driver-assistance systems such as Honda’s collision mitigation brake system(CMBS)can help achieve traffic safety.In this paper,the naturalistic driving study and a series of simulations are combined to better evaluate the performance of the CMBS in the Chinese traffic environment.First,because safety-critical situations can be diverse especially in the Chinese environment,the Chinese traffic-accident characteristics are analyzed according to accident statistics over the past 17 years.Next,10 Chinese traffic-accident scenarios accounting for more than 80%of traffic accidents are selected.For each typical scenario,353 representative cases are collected from the traffic-management department of Beijing.These real-world accident cases are then reconstructed by the traffic-accident-reconstruction software PC-Crash on the basis of accident-scene diagrams.This study also proposes a systematic analytical process for estimating the effectiveness of the technology using the co-simulation platform of PC-Crash and rateEFFECT,in which 176 simulations are analyzed in detail to assess the accident-avoidance performance of the CMBS.The overall collision-avoidance effectiveness reaches 82.4%,showing that the proposed approach is efficient for avoiding collisions,thereby enhancing traffic safety and improving traffic management.
基金supported by the Special Fund for Health Research in the Public Interest,China(Grant No.201202019)the National Key Science&Technology Special Projects on Major Infectious Diseases,China(Grant No.2012ZX10004-211).
文摘Background:Babesiosis is an uncommon but emerging tick-borne disease caused by the genus Babesia.In this case study,we report a case of human infection with a novel Babesia sp.in China.Findings:The patient in question had been suffering from repetitive occurrences of mild fever of unknown origin and fatigue for 10 years.Ring forms,tetrads,and one or two dots of chromatin or trophozoite-like organisms were observed in the patient’s thin blood smears and bone marrow smears.Using a confocal laser-scanning microscope,it was observed that the patient’s serum had reactivity with the surface proteins of the B.microti strain.Electron microscopy revealed oval red blood cells with 1~2μm of knob protrusions in the cellular membrane.The results of the Babesia-specific nested PCR assay for 18S rRNA confirmed the presence of Babesia infection.The construction of a phylogenetic relationship showed clustering with B.microti and B.duncani,which was identified as a novel Babesia species and named as Babesia sp.XXB/HangZhou.Azithromycin,doxycycline,and moxifloxacin hydrochloride were shown to relieve symptoms but were not as effective after continuous usage.After atovaquone(Mepron®)administration,the patient recovered from fever and tested negative for detection of Babesia-specific genes.Conclusion:Babesia sp.XXB/HangZhou is a novel Babesia species,which causes mild babesiosis in an immunocompetent patient.
文摘Background:Primary pulmonary amoeba is very rare and here we report a case of a 68-year-old man presenting with primary pulmonary amoeba after undergoing chemotherapy for lung adenocarcinoma.Case presentation:In October 2016,the man aged 68 was admitted to our hospital because of repeated cough for 8 months and hemoptysis for 1 month.He was diagnosed lung adenocarcinoma and underwent surgery in 2012 without receiving chemotherapy.In March 2016,the patients suffered recurrence of cancer and was treated with chemotherapy.After 2 months of chemotherapy,the patient had consistent cough with white sputum,and chest CT showed a local lung nodule.The physicians suspected that the patient had pulmonary infectious diseases,and he was treated with empirical antibacterial treatment.However,his symptom wasn’t relieved and later the percutaneous lung biopsy found trophozites of Entamoeba histolytica.After administration of metronidazole,the symptoms of the patient were markedly relieved and the lesions were absorbed.Conclusions:In such cases where patients with pulmonary nodules were in immunodeficiency state and had adequate but ineffective anti-bacterial treatment,Entamoeba histolytica infection could be one of the rare causes.Percutaneous lung biopsy should be recommended and specific dying for parasites should be done when necessary.
