In recent years,the two-dimensional(2D)transition metal dichalcogenides(TMDCs)have attracted renewed interest owing to their remarkable physical and chemical properties.Similar to that of graphene,the atomic thickness...In recent years,the two-dimensional(2D)transition metal dichalcogenides(TMDCs)have attracted renewed interest owing to their remarkable physical and chemical properties.Similar to that of graphene,the atomic thickness of TMDCs significantly limits their optoelectronic applications.In this study,we report a hybrid WS_(2)-optical-fibernanowire(WOFN)structure for broadband enhancement of the light-matter interactions,i.e.,light absorption,photoluminescence(PL)and second-harmonic generation(SHG),through evanescent field coupling.The interactions between the anisotropic light field of an optical fiber nanowire(OFN)and the anisotropic second-order susceptibility tensor of WS_(2) are systematically studied theoretically and experimentally.In particular,an efficient SHG in the WOFN appears to be 20 times larger than that in the same OFN before the WS_(2) integration under the same conditions.Moreover,we show that strain can efficiently manipulate the PL and SHG in the WOFN owing to the large configurability of the silica OFN.Our results demonstrate the potential applications of waveguide-coupled TMDCs structures for tunable high-performance photonic devices.展开更多
Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were establi...Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP deficiency.Notably,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory transcriptome.In total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD rats.Based on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating NAFLD.This study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.展开更多
文中采用蒙特卡罗随机抽样方法,研发了一套融合传统二维潜在震源区(下文简称“潜源”)和三维断层源的概率地震危险性算法。该算法不仅适用于传统的区域面源,同时还能考虑地震的破裂尺度并兼容三维断层源的概率地震危险性计算。文中研发...文中采用蒙特卡罗随机抽样方法,研发了一套融合传统二维潜在震源区(下文简称“潜源”)和三维断层源的概率地震危险性算法。该算法不仅适用于传统的区域面源,同时还能考虑地震的破裂尺度并兼容三维断层源的概率地震危险性计算。文中研发的算法可高效实现断层源地震事件集的三维模拟,并将地震破裂尺度引入到概率地震危险性计算中,显著提高了近断层地区地震危险性计算的合理性。为了提高程序的执行效率,算法采用预先在平面潜源中充填网格点的方式随机模拟地震事件在潜源内的均匀分布。对于椭圆衰减的地震危险性计算,算法采用了预先构建不同震级、距离及不同场点与潜源长轴方向夹角下的短轴距的三维矩阵,通过查表和插值方式直接获得相应场点的短轴距,避免了循环迭代逼近短轴距计算效率低下的问题。分别利用五代图的概率地震危险性程序和文中研发的算法,计算了湖南长-株-潭(长沙-株洲-湘潭)城市群所处的中强地震活动环境的区域地震危险性以及近断层源的常德、株洲2个场点在不同概率水平下(重现期分别为50a、 475a和2 475a)的地震危险性。比较研究表明,五代图的程序低估了三维断层源附近的地震危险性,且随着概率水平的降低,低估的程度越来越高。最后,利用太平洋地震工程中心(Pacific Earthquake Engineering Research Center, PEER)验证概率地震危险性程序的算例(数据集1案例10)验证了文中算法的可靠性。展开更多
基金sponsored by National Key R&D Program of China(2017YFA0303700)National Natural Science Foundation of China(61535005 and 61475069).
文摘In recent years,the two-dimensional(2D)transition metal dichalcogenides(TMDCs)have attracted renewed interest owing to their remarkable physical and chemical properties.Similar to that of graphene,the atomic thickness of TMDCs significantly limits their optoelectronic applications.In this study,we report a hybrid WS_(2)-optical-fibernanowire(WOFN)structure for broadband enhancement of the light-matter interactions,i.e.,light absorption,photoluminescence(PL)and second-harmonic generation(SHG),through evanescent field coupling.The interactions between the anisotropic light field of an optical fiber nanowire(OFN)and the anisotropic second-order susceptibility tensor of WS_(2) are systematically studied theoretically and experimentally.In particular,an efficient SHG in the WOFN appears to be 20 times larger than that in the same OFN before the WS_(2) integration under the same conditions.Moreover,we show that strain can efficiently manipulate the PL and SHG in the WOFN owing to the large configurability of the silica OFN.Our results demonstrate the potential applications of waveguide-coupled TMDCs structures for tunable high-performance photonic devices.
基金supported by the National Natural Science Foundation of China(81971875,82300661)Natural Science Foundation of Anhui province(2308085QH246)+3 种基金Natural Science Foundation of the Anhui Higher Education Institutions(KJ2021A0205)Basic and Clinical Cooperative Research Program of Anhui Medical University(2019xkjT002,2019xkjT022,2022xkjT013)Talent Training Program,School of Basic Medical Sciences,Anhui Medical University(2022YPJH102)National College Students Innovation and Entrepreneurship Training Program of China(202210366024)。
文摘Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP deficiency.Notably,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory transcriptome.In total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD rats.Based on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating NAFLD.This study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.
文摘文中采用蒙特卡罗随机抽样方法,研发了一套融合传统二维潜在震源区(下文简称“潜源”)和三维断层源的概率地震危险性算法。该算法不仅适用于传统的区域面源,同时还能考虑地震的破裂尺度并兼容三维断层源的概率地震危险性计算。文中研发的算法可高效实现断层源地震事件集的三维模拟,并将地震破裂尺度引入到概率地震危险性计算中,显著提高了近断层地区地震危险性计算的合理性。为了提高程序的执行效率,算法采用预先在平面潜源中充填网格点的方式随机模拟地震事件在潜源内的均匀分布。对于椭圆衰减的地震危险性计算,算法采用了预先构建不同震级、距离及不同场点与潜源长轴方向夹角下的短轴距的三维矩阵,通过查表和插值方式直接获得相应场点的短轴距,避免了循环迭代逼近短轴距计算效率低下的问题。分别利用五代图的概率地震危险性程序和文中研发的算法,计算了湖南长-株-潭(长沙-株洲-湘潭)城市群所处的中强地震活动环境的区域地震危险性以及近断层源的常德、株洲2个场点在不同概率水平下(重现期分别为50a、 475a和2 475a)的地震危险性。比较研究表明,五代图的程序低估了三维断层源附近的地震危险性,且随着概率水平的降低,低估的程度越来越高。最后,利用太平洋地震工程中心(Pacific Earthquake Engineering Research Center, PEER)验证概率地震危险性程序的算例(数据集1案例10)验证了文中算法的可靠性。
