本研究采用福林酚法测定樱桃酒中总酚的含量,并通过响应面法优化其工艺参数。在单因素实验基础上,以福林酚试剂用量、碳酸钠浓度、显色温度、显色时间和碳酸钠用量为影响因素,樱桃酒总酚含量为指标,响应面法进行分析和优化。结果表明,...本研究采用福林酚法测定樱桃酒中总酚的含量,并通过响应面法优化其工艺参数。在单因素实验基础上,以福林酚试剂用量、碳酸钠浓度、显色温度、显色时间和碳酸钠用量为影响因素,樱桃酒总酚含量为指标,响应面法进行分析和优化。结果表明,优化后得到最佳条件为:福林酚试剂2.1 m L、碳酸钠浓度63 g/L、碳酸钠用量8.32 m L,在25℃件下反应1.4 h,总酚含量为1085.2±0.16 mg/L。此回归模型拟合性良好,可用于预测总酚含量。根据此线性回归方程测定12个品种樱桃酒中总酚含量最高的为俄罗斯酸樱桃(1495.0 mg/L),雷尼含量最低(442.8 mg/L)。福林酚法操作简单,可用于不同品种樱桃酒总酚含量的测定。展开更多
目的:探究关节囊切开与髋关节镜分别结合髋臼周围截骨术治疗成人发育性髋关节发育不良的疗效。方法:回顾分析72例2021年5月至2022年6月入住我院的成人发育性髋关节发育不良患者的临床资料,分为关节囊切开组(n=35)和髋关节镜组(n=37)。...目的:探究关节囊切开与髋关节镜分别结合髋臼周围截骨术治疗成人发育性髋关节发育不良的疗效。方法:回顾分析72例2021年5月至2022年6月入住我院的成人发育性髋关节发育不良患者的临床资料,分为关节囊切开组(n=35)和髋关节镜组(n=37)。对比两组患者的手术情况,术前及术后采用髋骨X线检查测定髋关节情况,采用非骨关节炎髋关节评分(Non-Arthritis Hip Score,NAHS)测定患者关节功能,采用日常生活能力量表(Hip Outcome Score Activity of Daily Living Scale,HOS-ADL)测定患者活动能力,记录患者术后并发症发生情况。结果:两组患者手术情况,术后3 m术后髋关节情况对比均无明显差异(P>0.05),髋关节镜组相较于关节囊切开组术后3 m NAHS、HOS-ADL得分更高,坐骨神经损伤表现发生率明显更低(P<0.05)。结论:髋关节镜截骨术在短期改善成人发育性髋关节不良患者关节功能方面优势明显,可防止坐骨神经损伤。展开更多
The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays a...The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic X-rays.The nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton electrons.Despite the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 keV.The NaI(Tl)crystal demonstrated an"excess"light output in the 6-200 keV range,reaching a maximum"excess"of 9.2%at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma rays.Furthermore,we explored the underlying causes of the observed nonlinearity in these crystals.This study not only elucidates the detector responses of GECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.展开更多
Follistatin(FST) is an important regulator of skeletal muscle growth and adipose deposition through its ability to bind to several members of the transforming growth factor-β(TGF-β) superfamily, and thus may be a go...Follistatin(FST) is an important regulator of skeletal muscle growth and adipose deposition through its ability to bind to several members of the transforming growth factor-β(TGF-β) superfamily, and thus may be a good candidate for future animal breeding programs. However, the molecular mechanisms underlying the phenotypic changes have yet to be clarified in pig. We generated transgenic(TG) pigs that express human FST specifically in skeletal muscle tissues and characterized the phenotypic changes compared with the same tissues in wild-type pigs. The TG pigs showed increased skeletal muscle growth, decreased adipose deposition, and improved metabolism status(P<0.05). Transcriptome analysis detected important roles of the PIK3–AKT signaling pathway, calcium-mediated signaling pathway, and amino acid metabolism pathway in FST-induced skeletal muscle hypertrophy, and depot-specific oxidative metabolism changes in psoas major muscle. Furthermore, the lipid metabolism-related process was changed in adipose tissue in the TG pigs. Gene set enrichment analysis revealed that genes related to lipid synthesis, lipid catabolism, and lipid storage were down-regulated(P<0.01) in the TG pigs for subcutaneous fat, whereas genes related to lipid catabolism were significantly up-regulated(P<0.05) in the TG pigs for retroperitoneal fat compared with their expression levels in wild-type pigs. In liver, genes related to the TGF-β signaling pathway were over-represented in the TG pigs, which is consistent with the inhibitory role of FST in regulating TGF-β signaling. Together, these results provide new insights into the molecular mechanisms underlying the phenotypic changes in pig.展开更多
Nan'an Basin is a giant hydrocarbon basin,but its tectonic division scheme and associated fault systems has not been well understood.Based on newly acquired seismic data from the southwestern margin of the South C...Nan'an Basin is a giant hydrocarbon basin,but its tectonic division scheme and associated fault systems has not been well understood.Based on newly acquired seismic data from the southwestern margin of the South China Sea,this study analyzed the structural units,tectonic feature and geodynamics of the sedimentary basin.The new data suggests that the Nan0 an Basin is a rift basin oriented in the NE-SW direction,rather than a pull-apart basin induced by strike-slip faults along the western margin.The basin is a continuation of the rifts in the southwest South China Sea since the late Cretaceous.It continued rifting until the middle Miocene,even though oceanic crust occurred in the Southwest Subbasin.However,it had no transfer surface at the end of spreading,where it was characterized by a late middle Miocene unconformity(reflector T3).The Nan'an Basin can be divided into eight structural units by a series of NE-striking faults.This study provides evidences to confirm the relative importance and interplay between regional strike-slips and orthogonal displacement during basin development and deformation.The NE-SW-striking dominant rift basin indicates that the geodynamic drivers of tectonic evolution in the western margin of the South China Sea did not have a large strike-slip mechanism.Therefore,we conclude that a large strike-slip fault system did not exist in the western margin of the South China Sea.展开更多
In this study, recovery processes of isotactic polypropylene （iPP） melted spherulites at 135 ℃ after melting at higher temperatures （170 ℃-176 ℃） were investigated with polarized optical microscopy and Fourier ...In this study, recovery processes of isotactic polypropylene （iPP） melted spherulites at 135 ℃ after melting at higher temperatures （170 ℃-176 ℃） were investigated with polarized optical microscopy and Fourier transform infrared spectroscopy. The recovery temperature was fixed to exclude the interference from heterogeneous nuclei. After melting at temperatures between 170 ℃ and 174 ℃, the melted spherulite could recover back to the origin spberulite at low temperatures. Interestingly, a distinct infrared spectrum from iPP melt and crystal was observed in the early stage of recovery process after melting at low temperatures, where only IR bands resulting from short helices with 12 monomers or less can be seen, which indicates that the presence of crystal residues is not the necessary condition for the polymer memory effect. Avrami analysis further indicated that crystallization mainly took place in melted lamellae. After melting at higher temperatures, melted spherulite cannot recover. Based on above findings, it is proposed that the memory effect can be mainly ascribed to melted lamellae, during which crystalline order is lost but conformational order still exists. These conformational ordered segments formed aggregates, which can play as nucleation precursors at low temperatures.展开更多
文摘本研究采用福林酚法测定樱桃酒中总酚的含量,并通过响应面法优化其工艺参数。在单因素实验基础上,以福林酚试剂用量、碳酸钠浓度、显色温度、显色时间和碳酸钠用量为影响因素,樱桃酒总酚含量为指标,响应面法进行分析和优化。结果表明,优化后得到最佳条件为:福林酚试剂2.1 m L、碳酸钠浓度63 g/L、碳酸钠用量8.32 m L,在25℃件下反应1.4 h,总酚含量为1085.2±0.16 mg/L。此回归模型拟合性良好,可用于预测总酚含量。根据此线性回归方程测定12个品种樱桃酒中总酚含量最高的为俄罗斯酸樱桃(1495.0 mg/L),雷尼含量最低(442.8 mg/L)。福林酚法操作简单,可用于不同品种樱桃酒总酚含量的测定。
文摘目的:探究关节囊切开与髋关节镜分别结合髋臼周围截骨术治疗成人发育性髋关节发育不良的疗效。方法:回顾分析72例2021年5月至2022年6月入住我院的成人发育性髋关节发育不良患者的临床资料,分为关节囊切开组(n=35)和髋关节镜组(n=37)。对比两组患者的手术情况,术前及术后采用髋骨X线检查测定髋关节情况,采用非骨关节炎髋关节评分(Non-Arthritis Hip Score,NAHS)测定患者关节功能,采用日常生活能力量表(Hip Outcome Score Activity of Daily Living Scale,HOS-ADL)测定患者活动能力,记录患者术后并发症发生情况。结果:两组患者手术情况,术后3 m术后髋关节情况对比均无明显差异(P>0.05),髋关节镜组相较于关节囊切开组术后3 m NAHS、HOS-ADL得分更高,坐骨神经损伤表现发生率明显更低(P<0.05)。结论:髋关节镜截骨术在短期改善成人发育性髋关节不良患者关节功能方面优势明显,可防止坐骨神经损伤。
基金This work was supported by the National Key Research and Development Program(Nos.2022YFB3503600 and 2021YFA0718500)Strategic Priority Research Program of the Chinese Academy of Sciences(Nos.XDA15360102)National Natural Science Foundation of China(Nos.12273042 and 12075258).
文摘The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic X-rays.The nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton electrons.Despite the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 keV.The NaI(Tl)crystal demonstrated an"excess"light output in the 6-200 keV range,reaching a maximum"excess"of 9.2%at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma rays.Furthermore,we explored the underlying causes of the observed nonlinearity in these crystals.This study not only elucidates the detector responses of GECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.
基金supported by grants from the National Key R&D Program of China(2020YFA0509500)the National Natural Science Foundation of China(U19A2036,32102512,31872335,and 31802044)+1 种基金the National Special Foundation for Transgenic Species of China(2014ZX0800605B)the Sichuan Science and Technology Program,China(2021YFYZ0009 and 2021YFYZ0030)。
文摘Follistatin(FST) is an important regulator of skeletal muscle growth and adipose deposition through its ability to bind to several members of the transforming growth factor-β(TGF-β) superfamily, and thus may be a good candidate for future animal breeding programs. However, the molecular mechanisms underlying the phenotypic changes have yet to be clarified in pig. We generated transgenic(TG) pigs that express human FST specifically in skeletal muscle tissues and characterized the phenotypic changes compared with the same tissues in wild-type pigs. The TG pigs showed increased skeletal muscle growth, decreased adipose deposition, and improved metabolism status(P<0.05). Transcriptome analysis detected important roles of the PIK3–AKT signaling pathway, calcium-mediated signaling pathway, and amino acid metabolism pathway in FST-induced skeletal muscle hypertrophy, and depot-specific oxidative metabolism changes in psoas major muscle. Furthermore, the lipid metabolism-related process was changed in adipose tissue in the TG pigs. Gene set enrichment analysis revealed that genes related to lipid synthesis, lipid catabolism, and lipid storage were down-regulated(P<0.01) in the TG pigs for subcutaneous fat, whereas genes related to lipid catabolism were significantly up-regulated(P<0.05) in the TG pigs for retroperitoneal fat compared with their expression levels in wild-type pigs. In liver, genes related to the TGF-β signaling pathway were over-represented in the TG pigs, which is consistent with the inhibitory role of FST in regulating TGF-β signaling. Together, these results provide new insights into the molecular mechanisms underlying the phenotypic changes in pig.
基金This research was financially supported by Natural Science Foundation of China(U1701245,No.91228208)CGS project(DD20190213)CNPC project(kt 2021-02-02).
文摘Nan'an Basin is a giant hydrocarbon basin,but its tectonic division scheme and associated fault systems has not been well understood.Based on newly acquired seismic data from the southwestern margin of the South China Sea,this study analyzed the structural units,tectonic feature and geodynamics of the sedimentary basin.The new data suggests that the Nan0 an Basin is a rift basin oriented in the NE-SW direction,rather than a pull-apart basin induced by strike-slip faults along the western margin.The basin is a continuation of the rifts in the southwest South China Sea since the late Cretaceous.It continued rifting until the middle Miocene,even though oceanic crust occurred in the Southwest Subbasin.However,it had no transfer surface at the end of spreading,where it was characterized by a late middle Miocene unconformity(reflector T3).The Nan'an Basin can be divided into eight structural units by a series of NE-striking faults.This study provides evidences to confirm the relative importance and interplay between regional strike-slips and orthogonal displacement during basin development and deformation.The NE-SW-striking dominant rift basin indicates that the geodynamic drivers of tectonic evolution in the western margin of the South China Sea did not have a large strike-slip mechanism.Therefore,we conclude that a large strike-slip fault system did not exist in the western margin of the South China Sea.
基金financially supported by the China Postdoctoral Science Foundation(No.2012M521233)the Fundamental Research Funds for the Central Universities(WK2310000031)+3 种基金the National Natural Science Foundation of China(Nos.51033004,51227801,51303166)National Natural Science Funds for Distinguished Young Scholars(No.51325301)the 973 program of MOST(2010CB934504)supported by the Opening Project of Soochow University Biomedical Polymers Laboratory and the Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application(Soochow University)
文摘In this study, recovery processes of isotactic polypropylene （iPP） melted spherulites at 135 ℃ after melting at higher temperatures （170 ℃-176 ℃） were investigated with polarized optical microscopy and Fourier transform infrared spectroscopy. The recovery temperature was fixed to exclude the interference from heterogeneous nuclei. After melting at temperatures between 170 ℃ and 174 ℃, the melted spherulite could recover back to the origin spberulite at low temperatures. Interestingly, a distinct infrared spectrum from iPP melt and crystal was observed in the early stage of recovery process after melting at low temperatures, where only IR bands resulting from short helices with 12 monomers or less can be seen, which indicates that the presence of crystal residues is not the necessary condition for the polymer memory effect. Avrami analysis further indicated that crystallization mainly took place in melted lamellae. After melting at higher temperatures, melted spherulite cannot recover. Based on above findings, it is proposed that the memory effect can be mainly ascribed to melted lamellae, during which crystalline order is lost but conformational order still exists. These conformational ordered segments formed aggregates, which can play as nucleation precursors at low temperatures.
