By combination of the transient Raman spectroscopic measurement and the density functional theoretical calculations,the structural evolution and stability of TATB under shock compression was investigated.Due to the im...By combination of the transient Raman spectroscopic measurement and the density functional theoretical calculations,the structural evolution and stability of TATB under shock compression was investigated.Due to the improvement in synchronization control between two-stage light gas gun and the transient Raman spectra acquisition,as well as the sample preparation,the Raman peak of the N-O mode of TATB was firstly observed under shock pressure up to 13.6 GPa,noticeably higher than the upper limit of 8.5 GPa reported in available literatures.By taking into account of the continuous shift of the main peak and other observed Raman peaks,we did not distinguish any structural transition or any new species.Moreover,both the present Raman spectra and the time-resolved radiation of TATB during shock loading showed that TATB exhibits higher chemical stability than previous declaration.To reveal the detailed structural response and evolution of TATB under compression,the density functional theoretical calculations were conducted,and it was found that the pressure make N-O bond lengths shorter,nitro bond angles larger,and intermolecular and intra-molecular hydrogen bond interactions enhanced.The observed red shift of Raman peak was ascribed to the abnormal enhancement of H-bound effect on the scissor vibration mode of the nitro group.展开更多
Aiming at the spatial pattern phenomenon in biochemical reactions,an enzyme-reaction Sporns-Seelig model with cross-diffusion is chosen as study object.Applying the central manifold theory,normal form method,local Hop...Aiming at the spatial pattern phenomenon in biochemical reactions,an enzyme-reaction Sporns-Seelig model with cross-diffusion is chosen as study object.Applying the central manifold theory,normal form method,local Hopf bifurcation theorem and perturbation theory,we study Turing instability of the spatially homogeneous Hopf bifurcation periodic solutions.At last,the theoretical results are verified by numerical simulations.展开更多
为了准确描述负荷聚合商在与上级主体和同级主体进行能源交易过程中的各主体利益交互,以及用户侧储能昂贵且难以实施的问题。建立了综合能源运营商与负荷聚合商联盟之间的主从博弈模型,并特别考虑了拥有大量光伏用户的负荷聚合商之间的...为了准确描述负荷聚合商在与上级主体和同级主体进行能源交易过程中的各主体利益交互,以及用户侧储能昂贵且难以实施的问题。建立了综合能源运营商与负荷聚合商联盟之间的主从博弈模型,并特别考虑了拥有大量光伏用户的负荷聚合商之间的讨价还价博弈,以综合处理各主体之间的竞争与合作关系。为了实现负荷聚合商的低储高放策略,引入了云储能租赁的概念。采用二分法结合(alternating direction method of multipliers,ADMM)求解所构建的模型,以在各方持续互动过程中实现最大化的效益。研究结果表明,所建立的涵盖云储能租赁的混合博弈理论模型在保证各主体利益的同时能够制定合理的定价策略。展开更多
The disruption and reconstruction of the TREM2^(+) tissue resident macrophage(TRM)barrier on the surface of synovial lining play a key role in the activation and"remission"of rheumatoid arthritis(RA),which e...The disruption and reconstruction of the TREM2^(+) tissue resident macrophage(TRM)barrier on the surface of synovial lining play a key role in the activation and"remission"of rheumatoid arthritis(RA),which engender the prediction of this immunologic barrier as a potential driver for the achievement of"cure"in RA.However,strategies to promote the reconstruction of this barrier have not been reported,and the effect of patching this barrier remains unidentified.On the other hand,appropriate piezoelectric stimulation can reprogram macrophages,which has never been exerted on this barrier TRM yet.Herein,we design piezoelectric tetragonal BaTiO_(3)(BTO)ultrasound-driven nanorobots(USNRs)by the solvothermal synthesis method,which demonstrates satisfactory electro-mechanical conversion effects,paving the way to generate controllable electrical stimulation under ultrasound to reprogram the barrier TRM by minimally invasive injection into joint cavity.It is demonstrated that the immunologic barrier could be patched by this USNR effectively,thereby eliminating the hyperplasia of vessels and nerves(HVN)and synovitis.Additionally,TREM2 deficiency serum-transfected arthritis(STA)mice models are applied and proved the indispensable role of TREM2 in RA curing mediated by USNR.In all,our work is an interesting and important exploration to expand the classical tetragonal BTO nanoparticles in the treatment of autoimmune diseases,providing a new idea and direction for the biomedical application of piezoelectric ceramics.展开更多
The aim of this paper is the study of a double phase problems involving superlinear nonlinearities with a growth that need not satisfy the Ambrosetti-Rabinowitz condition.Using variational tools together with suitable...The aim of this paper is the study of a double phase problems involving superlinear nonlinearities with a growth that need not satisfy the Ambrosetti-Rabinowitz condition.Using variational tools together with suitable truncation and minimax techniques with Morse theory,the authors prove the existence of one and three nontrivial weak solutions,respectively.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.12072299,11902276)the Natural Science Foundation of Sichuan Province(Grant No.2022NSFSC1802)+1 种基金the Basic Research Project of Southwest Jiaotong University(Grant No.2682023ZTPY009)the National Key Laboratory for Shock Wave and Detonation Physics of China(Grant No.JCKYS2019212007)。
文摘By combination of the transient Raman spectroscopic measurement and the density functional theoretical calculations,the structural evolution and stability of TATB under shock compression was investigated.Due to the improvement in synchronization control between two-stage light gas gun and the transient Raman spectra acquisition,as well as the sample preparation,the Raman peak of the N-O mode of TATB was firstly observed under shock pressure up to 13.6 GPa,noticeably higher than the upper limit of 8.5 GPa reported in available literatures.By taking into account of the continuous shift of the main peak and other observed Raman peaks,we did not distinguish any structural transition or any new species.Moreover,both the present Raman spectra and the time-resolved radiation of TATB during shock loading showed that TATB exhibits higher chemical stability than previous declaration.To reveal the detailed structural response and evolution of TATB under compression,the density functional theoretical calculations were conducted,and it was found that the pressure make N-O bond lengths shorter,nitro bond angles larger,and intermolecular and intra-molecular hydrogen bond interactions enhanced.The observed red shift of Raman peak was ascribed to the abnormal enhancement of H-bound effect on the scissor vibration mode of the nitro group.
基金supported by Scientific Research and Innovation Fund for PhD Student:Research on the bifurcation problems of diffusive oncolytic virotherapy system(No.3072022CFJ2401).
文摘Aiming at the spatial pattern phenomenon in biochemical reactions,an enzyme-reaction Sporns-Seelig model with cross-diffusion is chosen as study object.Applying the central manifold theory,normal form method,local Hopf bifurcation theorem and perturbation theory,we study Turing instability of the spatially homogeneous Hopf bifurcation periodic solutions.At last,the theoretical results are verified by numerical simulations.
文摘为了准确描述负荷聚合商在与上级主体和同级主体进行能源交易过程中的各主体利益交互,以及用户侧储能昂贵且难以实施的问题。建立了综合能源运营商与负荷聚合商联盟之间的主从博弈模型,并特别考虑了拥有大量光伏用户的负荷聚合商之间的讨价还价博弈,以综合处理各主体之间的竞争与合作关系。为了实现负荷聚合商的低储高放策略,引入了云储能租赁的概念。采用二分法结合(alternating direction method of multipliers,ADMM)求解所构建的模型,以在各方持续互动过程中实现最大化的效益。研究结果表明,所建立的涵盖云储能租赁的混合博弈理论模型在保证各主体利益的同时能够制定合理的定价策略。
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.52072210 and 52111530230)Key R&D Projects of Social Development of Hainan Provincial Department of Science and Technology(Grant No.ZDYF2020137)Tsinghua University Beijing Union Medical CollegeeHospital Cooperation Project(Grant No.20191080871).
文摘The disruption and reconstruction of the TREM2^(+) tissue resident macrophage(TRM)barrier on the surface of synovial lining play a key role in the activation and"remission"of rheumatoid arthritis(RA),which engender the prediction of this immunologic barrier as a potential driver for the achievement of"cure"in RA.However,strategies to promote the reconstruction of this barrier have not been reported,and the effect of patching this barrier remains unidentified.On the other hand,appropriate piezoelectric stimulation can reprogram macrophages,which has never been exerted on this barrier TRM yet.Herein,we design piezoelectric tetragonal BaTiO_(3)(BTO)ultrasound-driven nanorobots(USNRs)by the solvothermal synthesis method,which demonstrates satisfactory electro-mechanical conversion effects,paving the way to generate controllable electrical stimulation under ultrasound to reprogram the barrier TRM by minimally invasive injection into joint cavity.It is demonstrated that the immunologic barrier could be patched by this USNR effectively,thereby eliminating the hyperplasia of vessels and nerves(HVN)and synovitis.Additionally,TREM2 deficiency serum-transfected arthritis(STA)mice models are applied and proved the indispensable role of TREM2 in RA curing mediated by USNR.In all,our work is an interesting and important exploration to expand the classical tetragonal BTO nanoparticles in the treatment of autoimmune diseases,providing a new idea and direction for the biomedical application of piezoelectric ceramics.
基金supported by the National Natural Science Foundation of China (No. 11201095)the Fundamental Research Funds for the Central Universities (No. 3072022TS2402)+1 种基金the Postdoctoral research startup foundation of Heilongjiang (No. LBH-Q14044)the Science Research Funds for Overseas Returned Chinese Scholars of Heilongjiang Province (No. LC201502)
文摘The aim of this paper is the study of a double phase problems involving superlinear nonlinearities with a growth that need not satisfy the Ambrosetti-Rabinowitz condition.Using variational tools together with suitable truncation and minimax techniques with Morse theory,the authors prove the existence of one and three nontrivial weak solutions,respectively.
