Dissecting the genetic regulation of gene expression is critical for understanding phenotypic variation and species evolution.However,our understanding of the transcriptional variability in sweet potato remains limite...Dissecting the genetic regulation of gene expression is critical for understanding phenotypic variation and species evolution.However,our understanding of the transcriptional variability in sweet potato remains limited.Here,we analyzed two publicly available datasets to explore the landscape of transcriptomic variations and its genetic basis in the storage roots of sweet potato.The comprehensive analysis identified a total of 724,438 high-confidence single nucleotide polymorphisms(SNPs)and 26,026 expressed genes.Expression quantitative trait locus(eQTL)analysis revealed 4408 eQTLs regulating the expression of 3646 genes,including 2261 local eQTLs and 2147 distant eQTLs.Two distant eQTL hotspots were found with target genes significantly enriched in specific functional classifications.By combining the information from regulatory network analyses,eQTLs and association mapping,we found that IbMYB1-2 acts as a master regulator and is the major gene responsible for the activation of anthocyanin biosynthesis in the storage roots of sweet potato.Our study provides the first insight into the genetic architecture of genome-wide expression variation in sweet potato and can be used to investigate the potential effects of genetic variants on key agronomic traits in sweet potato.展开更多
采用45nm SOI CMOS工艺,设计了一种应用于毫米波系统的宽调谐范围VCO。采用具有高Q值且长度可灵活设计的开关耦合传输线(SCTL)作为谐振腔电感,通过控制耦合开关改变传输线的等效感值,在保持低相位噪声、不增加功耗和面积的情况下,提高了...采用45nm SOI CMOS工艺,设计了一种应用于毫米波系统的宽调谐范围VCO。采用具有高Q值且长度可灵活设计的开关耦合传输线(SCTL)作为谐振腔电感,通过控制耦合开关改变传输线的等效感值,在保持低相位噪声、不增加功耗和面积的情况下,提高了VCO的调谐范围。后仿真结果表明,不使用耦合开关的TL-VCO的调谐范围为45.6～57.1GHz(22.4%),SCTLVCO的调谐范围为42.25～59.92GHz(34.6%)。相比TL-VCO,SCTL-VCO的调谐范围增大了53.7%。在整个调谐范围内,相位噪声为-112.1～-120.4dBc/Hz@10 MHz,相应的FOM和FOMT分别为-178.3～-182.6dBc/Hz和-189.1～-193.4dBc/Hz,电源电压为0.7V,VCO核心功耗为8.6～10.8mW,面积为0.005 4mm^2。展开更多
基金supported by the National Key R&D Program of China(Nos.2018YFD1000705,2018YFD1000700)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)+3 种基金the China Agriculture Research System(CARS-10-B03)the Natural Science Foundation of Jiangsu Province(No.BK20190995)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.19KJB210002)the Natural Science Foundation of Xuzhou City(No.KC19070)the Natural Science Foundation by Jiangsu Normal University(Nos.18XLRX030,18XLRX031).
文摘Dissecting the genetic regulation of gene expression is critical for understanding phenotypic variation and species evolution.However,our understanding of the transcriptional variability in sweet potato remains limited.Here,we analyzed two publicly available datasets to explore the landscape of transcriptomic variations and its genetic basis in the storage roots of sweet potato.The comprehensive analysis identified a total of 724,438 high-confidence single nucleotide polymorphisms(SNPs)and 26,026 expressed genes.Expression quantitative trait locus(eQTL)analysis revealed 4408 eQTLs regulating the expression of 3646 genes,including 2261 local eQTLs and 2147 distant eQTLs.Two distant eQTL hotspots were found with target genes significantly enriched in specific functional classifications.By combining the information from regulatory network analyses,eQTLs and association mapping,we found that IbMYB1-2 acts as a master regulator and is the major gene responsible for the activation of anthocyanin biosynthesis in the storage roots of sweet potato.Our study provides the first insight into the genetic architecture of genome-wide expression variation in sweet potato and can be used to investigate the potential effects of genetic variants on key agronomic traits in sweet potato.
文摘采用45nm SOI CMOS工艺,设计了一种应用于毫米波系统的宽调谐范围VCO。采用具有高Q值且长度可灵活设计的开关耦合传输线(SCTL)作为谐振腔电感,通过控制耦合开关改变传输线的等效感值,在保持低相位噪声、不增加功耗和面积的情况下,提高了VCO的调谐范围。后仿真结果表明,不使用耦合开关的TL-VCO的调谐范围为45.6～57.1GHz(22.4%),SCTLVCO的调谐范围为42.25～59.92GHz(34.6%)。相比TL-VCO,SCTL-VCO的调谐范围增大了53.7%。在整个调谐范围内,相位噪声为-112.1～-120.4dBc/Hz@10 MHz,相应的FOM和FOMT分别为-178.3～-182.6dBc/Hz和-189.1～-193.4dBc/Hz,电源电压为0.7V,VCO核心功耗为8.6～10.8mW,面积为0.005 4mm^2。
