Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can p...Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis.展开更多
In view of the environment character of the soil and content of the soil organic carbon, 278 species of grass and frutex were introduced from abroad and China, Some were selected by applied production and plantation b...In view of the environment character of the soil and content of the soil organic carbon, 278 species of grass and frutex were introduced from abroad and China, Some were selected by applied production and plantation benefit investigations. The results showed that： In the arid-hot valleys of Yuanmou the selected species showed the characteristics of fast growth and high yield （38 227.00 kg/hm2）, high nutrition value （CP% content of legu- minous grass and frutex were 22.47%）, as well as the strong ad- versity resistance to high air temperature and arid climate （soil humidity was 3.4%）. The selected species not only effectively meliorated soil and increased fertility, but also improved small environment weather.展开更多
Single-cell RNA sequencing(scRNA-seq)is useful for exploring cell heterogeneity.For large animals,however,little is known regarding spermatogonial stem cell(SSC)selfrenewal regulation,especially in dairy goats.In this...Single-cell RNA sequencing(scRNA-seq)is useful for exploring cell heterogeneity.For large animals,however,little is known regarding spermatogonial stem cell(SSC)selfrenewal regulation,especially in dairy goats.In this study,we described a high-resolution scRNA-seq atlas derived from a dairy goat.We identified six somatic cell and five spermatogenic cell subtypes.During spermatogenesis,genes with significantly changed expression were mainly enriched in the Notch,TGF-β,and Hippo signaling pathways as well as the signaling pathway involved in the regulation of stem cell pluripotency.We detected and screened specific candidate marker genes(TKTL1 and AES)for spermatogonia.Our study provides new insights into goat spermatogenesis and the development of testicular somatic cells.展开更多
目的 评估社会组织参与艾滋病防治基金(China AIDS Fund for Non-governmental Organizations,CAFNGO)对我国艾滋病防治工作的促进作用,总结经验与教训,并提出建议。方法 围绕2016—2020年CAFNGO重点人群干预及人类免疫缺陷病毒(human i...目的 评估社会组织参与艾滋病防治基金(China AIDS Fund for Non-governmental Organizations,CAFNGO)对我国艾滋病防治工作的促进作用,总结经验与教训,并提出建议。方法 围绕2016—2020年CAFNGO重点人群干预及人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者和艾滋病患者随访关怀两个核心领域,系统收集和分析投入、产出和效果,并与国家和省级相关指标进行对比分析。结果2016—2020年CAFNGO累计投入资金2.79亿元人民币,其中93.19%来自中央财政经费,平均每年支持800个社会组织参与艾滋病防治工作;累计为179万重点人群提供HIV抗体检测服务,占同期全国重点人群HIV抗体检测人数的17.25%,新发现HIV感染者46 118例,占同期全国新发现HIV感染者的6.67%,其中,新发现男男同性性行为人群(men who have sex with men,MSM) HIV感染者45 045例,占同期全国新发现经同性性途径感染者的26.58%;累计为31.53万例HIV感染者和艾滋病患者提供每年至少两次面对面随访关怀服务,其抗病毒治疗率及配偶检测比例均显著提高。结论 CAFNGO对促进社会组织参与HIV感染者发现以及HIV感染者和艾滋病患者随访质量的提升发挥了重要的补充作用,可结合当前艾滋病防治领域的新技术和新策略,在筹资渠道、投入地区分布、干预模式及策略等方面探索,以发挥CAFNGO独特的优势和作用。展开更多
The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 3...The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.展开更多
基金supported by grants from the National High Technology Research and Development Program of China(863 Program)(No.2012AA02A501)the Chinese State Key Basic Research Project(No.2011CB504805)the National Natural Science Foundation of China(No.81272952 and No.81472522)
文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis.
基金the National Science and Technology Sup-porting Program in the Eleventh Five-Year Plan of China (2006BAC01A11)
文摘In view of the environment character of the soil and content of the soil organic carbon, 278 species of grass and frutex were introduced from abroad and China, Some were selected by applied production and plantation benefit investigations. The results showed that： In the arid-hot valleys of Yuanmou the selected species showed the characteristics of fast growth and high yield （38 227.00 kg/hm2）, high nutrition value （CP% content of legu- minous grass and frutex were 22.47%）, as well as the strong ad- versity resistance to high air temperature and arid climate （soil humidity was 3.4%）. The selected species not only effectively meliorated soil and increased fertility, but also improved small environment weather.
基金supported by the National Natural Science Foundation of China(31572399,32072806,32072815,32002246,61772431,62072377)Program of Shaanxi Province Science and Technology Innovation Team(2019TD-036)+4 种基金Program of State Key Lab of Reproductive Regulation&Breeding of Grassland Livestock(SKL-OT-201801)Program of State Key Laboratory of Respiratory Disease(SKLRD-OP-202114)Science and Technology Major Project of Inner Mongolia Autonomous Region of China(ZDZX2018065)the First-class University and Academic Program from Northwest A&F University(Z1010221003)Financial aid for basic operation fee of Central University(Z1090219146)。
文摘Single-cell RNA sequencing(scRNA-seq)is useful for exploring cell heterogeneity.For large animals,however,little is known regarding spermatogonial stem cell(SSC)selfrenewal regulation,especially in dairy goats.In this study,we described a high-resolution scRNA-seq atlas derived from a dairy goat.We identified six somatic cell and five spermatogenic cell subtypes.During spermatogenesis,genes with significantly changed expression were mainly enriched in the Notch,TGF-β,and Hippo signaling pathways as well as the signaling pathway involved in the regulation of stem cell pluripotency.We detected and screened specific candidate marker genes(TKTL1 and AES)for spermatogonia.Our study provides new insights into goat spermatogenesis and the development of testicular somatic cells.
文摘目的 评估社会组织参与艾滋病防治基金(China AIDS Fund for Non-governmental Organizations,CAFNGO)对我国艾滋病防治工作的促进作用,总结经验与教训,并提出建议。方法 围绕2016—2020年CAFNGO重点人群干预及人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者和艾滋病患者随访关怀两个核心领域,系统收集和分析投入、产出和效果,并与国家和省级相关指标进行对比分析。结果2016—2020年CAFNGO累计投入资金2.79亿元人民币,其中93.19%来自中央财政经费,平均每年支持800个社会组织参与艾滋病防治工作;累计为179万重点人群提供HIV抗体检测服务,占同期全国重点人群HIV抗体检测人数的17.25%,新发现HIV感染者46 118例,占同期全国新发现HIV感染者的6.67%,其中,新发现男男同性性行为人群(men who have sex with men,MSM) HIV感染者45 045例,占同期全国新发现经同性性途径感染者的26.58%;累计为31.53万例HIV感染者和艾滋病患者提供每年至少两次面对面随访关怀服务,其抗病毒治疗率及配偶检测比例均显著提高。结论 CAFNGO对促进社会组织参与HIV感染者发现以及HIV感染者和艾滋病患者随访质量的提升发挥了重要的补充作用,可结合当前艾滋病防治领域的新技术和新策略,在筹资渠道、投入地区分布、干预模式及策略等方面探索,以发挥CAFNGO独特的优势和作用。
基金support from diverse funding sources,including the National Key Program for S&T Research and Development of the Ministry of Science and Technology(MOST),Yifang Wang's Science Studio of the Ten Thousand Talents Project,the CAS Key Foreign Cooperation Grant,the National Natural Science Foundation of China(NSFC)Beijing Municipal Science&Technology Commission,the CAS Focused Science Grant,the IHEP Innovation Grant,the CAS Lead Special Training Programthe CAS Center for Excellence in Particle Physics,the CAS International Partnership Program,and the CAS/SAFEA International Partnership Program for Creative Research Teams.
文摘The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.
