Chronic fatigue syndrome is a neurological disorder characterized by extreme fatigue that lasts for a long time and doesn't alleviate with rest.The number of the cases has been increasing during the era of COVID-1...Chronic fatigue syndrome is a neurological disorder characterized by extreme fatigue that lasts for a long time and doesn't alleviate with rest.The number of the cases has been increasing during the era of COVID-19 pandemic.Acupuncture may have some effect on chronic fatigue syndrome,but its mechanism remains unclear.This article was to summarize the specific manifestations of abnormal central mechanism in patients with chronic fatigue syndrome through laboratory tests and neuroimaging.It was found from the laboratory evaluation that there were changes in the structure of the frontal cortex,thalamus and other brain tissues;factors,including IFN-a and IL-10 in cerebrospinal fluid were found abnormal;results of oxidative and nitrosative stress and changes in neurobiochemical substances,e.g.hypothalamus hormone levels and neurotransmitter concentrations,were observed.With magnetic resonance imaging and positron emission tomography,it was shown that the partial brain of persons with chronic fatigue syndrome had morphological changes with diminished grey matter and white;changes in cerebral blood flow velocity caused by decreased perfusion and functional activity with abnormal connectivity in brain were detected.In addition,there was significant decrease in glucose metabolism accompanied with neuroinflammatory response;metabolic disorders of serotonergic,cholinergic,glutamatergic and yaminobutyric acid energy neurotransmitters were also discovered.The regulatory effect of acupuncture on the above central neurological abnormalities in chronic fatigue syndrome model animals was elaborated,and the direction for further research was analyzed in order to provide ideas for further research on the central mechanism of acupuncture treatment for chronic fatigue syndrome.展开更多
ObjectivesTo investigate the clinical efficacy of surrounding fire needling combined with electroacupuncture (EA) at Jiājĭ (夹脊EX-B2) on acute herpes zoster, and explore the potential mechanism of this combined trea...ObjectivesTo investigate the clinical efficacy of surrounding fire needling combined with electroacupuncture (EA) at Jiājĭ (夹脊EX-B2) on acute herpes zoster, and explore the potential mechanism of this combined treatment by measuring the changes of serum inflammatory cytokines and pain mediators.MethodsSixty patients with acute herpes zoster were randomly assigned to either acupuncture plus western medicine group or western medicine group. In the western medicine group, the patients took orally mecobalamin and ganciclovir for 14 consecutive days. In the acupuncture plus western medicine group, on the base of the western medicine, the surrounding fire needling (fire needling was operated swiftly toward the center of skin lesions.) combined with EA at EX-B2 was provided. Acupoints of EX-B2 were selected based on the nerve ganglion corresponding to the skin lesions, as well as two adjacent nerve ganglions(one level upwards and one downwards) to the lesions, and were stimulated with EA once daily for 14 days. The change of symptoms from the blister eruption to scabbing and decrustation were observed. The score of visual analogue scale (VAS), serum inflammatory cytokines (interleukin-1β, interleukin-6, tumor necrosis factor-α) and pain mediators (calcitonin gene related peptide, substance P) before and after treatment, the scores of Pittsburgh sleep quality index (PSQI) and Hamilton depression scale (HAMD) before and after treatment as well as at 1 month of follow-up, and the overall effective rate and the incidence of post-hepatic neuralgia at 1 month of follow-up were assessed and compared between two groups, respectively.ResultsAfter treatment completion, the time of blister relief, scabbing and decrustation in the acupuncture plus western medicine group was significantly shorter when compared with that of the western medicine group (all P < 0.05). After treatment, VAS score, PSQI score and HAMD score were all reduced significantly when compared with that before treatment within group (P < 0.05). These score展开更多
基金Supported by the National Natural Science Foundation of China:No.82074539the National Natural Science Foundation of China:No.81704170+2 种基金the Natural Science Foundation of Heilongjiang Province:No.LH2020H092the Heilongjiang Postdoctoral Scientific Research Developmental Fund:No.LBH-Q.18117the National Key Talents Project of Traditional Chinese Medicine Innovation。
文摘Chronic fatigue syndrome is a neurological disorder characterized by extreme fatigue that lasts for a long time and doesn't alleviate with rest.The number of the cases has been increasing during the era of COVID-19 pandemic.Acupuncture may have some effect on chronic fatigue syndrome,but its mechanism remains unclear.This article was to summarize the specific manifestations of abnormal central mechanism in patients with chronic fatigue syndrome through laboratory tests and neuroimaging.It was found from the laboratory evaluation that there were changes in the structure of the frontal cortex,thalamus and other brain tissues;factors,including IFN-a and IL-10 in cerebrospinal fluid were found abnormal;results of oxidative and nitrosative stress and changes in neurobiochemical substances,e.g.hypothalamus hormone levels and neurotransmitter concentrations,were observed.With magnetic resonance imaging and positron emission tomography,it was shown that the partial brain of persons with chronic fatigue syndrome had morphological changes with diminished grey matter and white;changes in cerebral blood flow velocity caused by decreased perfusion and functional activity with abnormal connectivity in brain were detected.In addition,there was significant decrease in glucose metabolism accompanied with neuroinflammatory response;metabolic disorders of serotonergic,cholinergic,glutamatergic and yaminobutyric acid energy neurotransmitters were also discovered.The regulatory effect of acupuncture on the above central neurological abnormalities in chronic fatigue syndrome model animals was elaborated,and the direction for further research was analyzed in order to provide ideas for further research on the central mechanism of acupuncture treatment for chronic fatigue syndrome.
基金Supported by TCM Evidence-based Capacity Building Project of State Administration of Traditional Chinese Medicine:2019XZZX-ZJ005。
文摘ObjectivesTo investigate the clinical efficacy of surrounding fire needling combined with electroacupuncture (EA) at Jiājĭ (夹脊EX-B2) on acute herpes zoster, and explore the potential mechanism of this combined treatment by measuring the changes of serum inflammatory cytokines and pain mediators.MethodsSixty patients with acute herpes zoster were randomly assigned to either acupuncture plus western medicine group or western medicine group. In the western medicine group, the patients took orally mecobalamin and ganciclovir for 14 consecutive days. In the acupuncture plus western medicine group, on the base of the western medicine, the surrounding fire needling (fire needling was operated swiftly toward the center of skin lesions.) combined with EA at EX-B2 was provided. Acupoints of EX-B2 were selected based on the nerve ganglion corresponding to the skin lesions, as well as two adjacent nerve ganglions(one level upwards and one downwards) to the lesions, and were stimulated with EA once daily for 14 days. The change of symptoms from the blister eruption to scabbing and decrustation were observed. The score of visual analogue scale (VAS), serum inflammatory cytokines (interleukin-1β, interleukin-6, tumor necrosis factor-α) and pain mediators (calcitonin gene related peptide, substance P) before and after treatment, the scores of Pittsburgh sleep quality index (PSQI) and Hamilton depression scale (HAMD) before and after treatment as well as at 1 month of follow-up, and the overall effective rate and the incidence of post-hepatic neuralgia at 1 month of follow-up were assessed and compared between two groups, respectively.ResultsAfter treatment completion, the time of blister relief, scabbing and decrustation in the acupuncture plus western medicine group was significantly shorter when compared with that of the western medicine group (all P < 0.05). After treatment, VAS score, PSQI score and HAMD score were all reduced significantly when compared with that before treatment within group (P < 0.05). These score
