Background： Central nervous system （CNS） involvement is found in many patients with hemophagocytic lymphohistiocytosis （HLH）. In this study, we mainly analyzed neurological symptoms, imaging findings, cerebrospin...Background： Central nervous system （CNS） involvement is found in many patients with hemophagocytic lymphohistiocytosis （HLH）. In this study, we mainly analyzed neurological symptoms, imaging findings, cerebrospinal fluid （CSF）, and their relationship with outcomes of HLH children. Methods： Related data of 179 Chinese pediatric patients with HLH admitted to our center from January 2010 to December 2015 were analyzed retrospectively. Diagnosis and treatment were based on the H LH-2004 protocol. Two-tailed Chi-squared test was used to compare between different groups, and Kaplan-Meier survival curves were used to analyze the overall survival （OS） of patients with HLH. Results： In the present study, 21.2% （38/179） of total patients had neurological symptoms including seizure, irritability, somnolence, and unconsciousness. There were 80 （50.0%, excluding 19 patients without imaging data） patients with cranial imaging abnormalities. There were 14.7% （17/116, excluding 63 patients who did not accept lumbar puncture） of patients with abnormal CSF results. CNS involvement is defined as abnormalities in one or more of CNS symptoms, radiological findings, and CSF. Thus, 60.3% of them had CNS involvement, As for the prognosis, the median follow-up time was 3.2 years （17 lost to follow-up）. The probable 3-year OS of children was higher without CNS involvement （86.0% ± 4.6%） than those with CNS involvement （68.9% ± 4.9%, hazard ratio [HR] = 2.286, P = 0.019）, Among them, the probable 3-year OS of children without CNS symptoms was 76.0% ± 3.8%, higher than with CNS symptoms （59.5% ± 8.1%, HR = 2.147, P ： 0.047）. The 3-year OS of children with abnormal CSF was 64.7% ± 11.6%, compared with normal CSF （85.1% ± 3.7%, HR = 0.255, P = 0.038）. Conclusions： HLH patients with CNS involvement might have worse outcomes compared with those without CNS involvement, and CNS symptoms and CSF changes are more important to access the prognosis than imaging abnormality.展开更多
Remote-sensing images of Mars contain rich information about its surface morphology,topography,and geological structure.These data are fundamental for scientific research and exploration.Prior to China’s first Mars e...Remote-sensing images of Mars contain rich information about its surface morphology,topography,and geological structure.These data are fundamental for scientific research and exploration.Prior to China’s first Mars exploration mission,data from six advanced optical imaging systems of different missions in the Martian orbit had been used to generate Mars global/near-global image datasets with spatial resolutions of better than 1 km:the visual imaging system of Mariner 9,visual imaging subsystem cameras of Viking 1 and 2,Mars Orbiter Camera-Wide Angle(MOC-WA)of the Mars Global Surveyor(MGS),Context Camera(CTX)of the Mars Reconnaissance Orbiter(MRO),High Resolution Stereo Camera(HRSC)of Mars Express(MEX),and Thermal Emission Imaging System(THEMIS)of the Mars Odyssey Orbiter[1,2].展开更多
卷对卷(R2R)凹版印刷具有高的边缘分辨率、可图案化、高加工速度等优势,是制备大面积柔性有机太阳能电池(FOSCs)的一种可行技术.有机光活性层的薄膜质量是决定有机太阳能电池器件性能的关键.对于凹版印刷过程而言,墨水的转移是影响印刷...卷对卷(R2R)凹版印刷具有高的边缘分辨率、可图案化、高加工速度等优势,是制备大面积柔性有机太阳能电池(FOSCs)的一种可行技术.有机光活性层的薄膜质量是决定有机太阳能电池器件性能的关键.对于凹版印刷过程而言,墨水的转移是影响印刷薄膜厚度和质量的关键.本文深入研究了有机光活性层的墨水粘度对墨水转移率和薄膜缺陷的影响.我们开发了紫外可见光谱法,量化凹版印刷过程中墨水的转移率.通过对墨水的流变行为分析、流体动力学模拟和实验验证,深入研究了油墨粘度与油墨转移率、膜厚和膜均匀性之间的关系.结果表明,油墨粘度约为25 m Pa·s是R2R凹版印刷有机光活性层薄膜的适合粘度.通过对油墨配方的优化,我们制备了全R2R印刷FOSCs,其中1 cm^(2);电池的效率超过12%.展开更多
Purpose Our purpose was to compare the difference between hot-air dried American ginseng(HDAG)(Panacis Quinquefolii Radix)and freeze-dried American ginseng(FDAG)(Panacis Quinquefolii Radix)and provide a better drying ...Purpose Our purpose was to compare the difference between hot-air dried American ginseng(HDAG)(Panacis Quinquefolii Radix)and freeze-dried American ginseng(FDAG)(Panacis Quinquefolii Radix)and provide a better drying approach for improv-ing the quality of American ginseng(Panacis Quinquefolii Radix).Methods In our present study,we compared the appearance features of HDAG and FDAG using a CR-410 colorimeter and scanning electron microscopy.Furthermore,we qualitatively and quantitatively determined ginsenosides in HDAG and FDAG by using UPLC-Q Exactive Orbitrap-MS/MS and high-performance liquid chromatography.Results Our present results showed that compared to the hot-air drying method,freeze-drying(FD)has obvious advantages in not only good appearances but also higher bioactive constituents for drying the American ginseng(Panacis Quinquefolii Radix).Conclusion FD is beneficial for the retention of ginsenosides in American ginseng(Panacis Quinquefolii Radix)and also helpful for maintaining the bioactive effects of this functional food.展开更多
We investigate the medium modifications of momentum splitting fraction and groomed jet radius with both dynamical grooming and soft drop algorithms in heavy-ion collisions.In the calculation,the partonic spectrum of i...We investigate the medium modifications of momentum splitting fraction and groomed jet radius with both dynamical grooming and soft drop algorithms in heavy-ion collisions.In the calculation,the partonic spectrum of initial hard scattering in p+p collisions is provided by the event generator PYTHIA8,and the energy loss of fast parton traversing in a hot/dense quantum-chromodynamic medium is simulated with the linear Boltzmann transport model.We predict the normalized distributions of the groomed jet radiusθ_(g)and momentum splitting fraction z_(g)with the dynamical grooming algorithm in Pb+Pb collisions at(sNN)~(1/2)=5.02 TeV,then compare these quantities in dynamical grooming at a=0.1,with that in soft drop at z_(out)=0.1 andβ=0.It is found that the normalized distribution ratios Pb+Pb/p+p with respect to z_(g)in z_(cut)=0.1,β=0 soft drop case are close to unity,those in a=0.1 dynamical grooming case show enhancement at small z_(g),and Pb+Pb/p+p with respect toθ_(g)in the dynamical grooming case demonstrate weaker modification than those in the soft drop counterparts.We further calculate the groomed jet number averaged momentum splitting fraction_(jets)and averaged groomed jet radius<θ_(g)>_(jets)in p+p and A+A for both grooming cases in three p_T~(ch jet)intervals,and find that the originally generated well balanced groomed jets will become more momentum imbalanced and jet size less narrowed due to jet quenching,and weaker medium modification of z_(g)andθ_(g)in the a=0.1 dynamical grooming case than in the soft drop counterparts.展开更多
基金This work was supported by grants from the Technology Key Projects （No. 2017ZX09304029004）, the Beijing Municipal Science and Technology Commission （No. Z171100001017050）, the National Natural Science Foundation of China （No. 81700186）, the Scientific Research Common Program of Beijing Municipal Commission of Education （No. KM201710025019）, the Pediatric Project of Ai You Foundation （No. AYEK201802）, and the Talent Training Project-Fostering Fund of National Natural Science Foundation of Beijing Children＇s Hospital, Capital Medical University （No. GPY201713）.
文摘Background： Central nervous system （CNS） involvement is found in many patients with hemophagocytic lymphohistiocytosis （HLH）. In this study, we mainly analyzed neurological symptoms, imaging findings, cerebrospinal fluid （CSF）, and their relationship with outcomes of HLH children. Methods： Related data of 179 Chinese pediatric patients with HLH admitted to our center from January 2010 to December 2015 were analyzed retrospectively. Diagnosis and treatment were based on the H LH-2004 protocol. Two-tailed Chi-squared test was used to compare between different groups, and Kaplan-Meier survival curves were used to analyze the overall survival （OS） of patients with HLH. Results： In the present study, 21.2% （38/179） of total patients had neurological symptoms including seizure, irritability, somnolence, and unconsciousness. There were 80 （50.0%, excluding 19 patients without imaging data） patients with cranial imaging abnormalities. There were 14.7% （17/116, excluding 63 patients who did not accept lumbar puncture） of patients with abnormal CSF results. CNS involvement is defined as abnormalities in one or more of CNS symptoms, radiological findings, and CSF. Thus, 60.3% of them had CNS involvement, As for the prognosis, the median follow-up time was 3.2 years （17 lost to follow-up）. The probable 3-year OS of children was higher without CNS involvement （86.0% ± 4.6%） than those with CNS involvement （68.9% ± 4.9%, hazard ratio [HR] = 2.286, P = 0.019）, Among them, the probable 3-year OS of children without CNS symptoms was 76.0% ± 3.8%, higher than with CNS symptoms （59.5% ± 8.1%, HR = 2.147, P ： 0.047）. The 3-year OS of children with abnormal CSF was 64.7% ± 11.6%, compared with normal CSF （85.1% ± 3.7%, HR = 0.255, P = 0.038）. Conclusions： HLH patients with CNS involvement might have worse outcomes compared with those without CNS involvement, and CNS symptoms and CSF changes are more important to access the prognosis than imaging abnormality.
基金supported by the China National Space Administration(CNSA)the National Key R&D Program of China(2022YFF0503204)+1 种基金the Key Research Program of the Chinese Academy of Sciences(ZDBS-SSW-TLC001)the National Natural Science Foundation of China(12203073,42371384)。
文摘Remote-sensing images of Mars contain rich information about its surface morphology,topography,and geological structure.These data are fundamental for scientific research and exploration.Prior to China’s first Mars exploration mission,data from six advanced optical imaging systems of different missions in the Martian orbit had been used to generate Mars global/near-global image datasets with spatial resolutions of better than 1 km:the visual imaging system of Mariner 9,visual imaging subsystem cameras of Viking 1 and 2,Mars Orbiter Camera-Wide Angle(MOC-WA)of the Mars Global Surveyor(MGS),Context Camera(CTX)of the Mars Reconnaissance Orbiter(MRO),High Resolution Stereo Camera(HRSC)of Mars Express(MEX),and Thermal Emission Imaging System(THEMIS)of the Mars Odyssey Orbiter[1,2].
基金supported by the National Natural Science Foundation of China(22135001)Young Cross Team Project of CAS(JCTD-2021-14)+1 种基金“Dual Carbon”Science and Technology Innovation of Jiangsu Province(Industrial Prospect and Key Technology Research Program)(BE2022021)Vacuum Interconnected Nanotech Workstation,Suzhou Institute of Nano-Tech and Nano-Bionics,and Chinese Academy of Sciences(CAS)。
文摘卷对卷(R2R)凹版印刷具有高的边缘分辨率、可图案化、高加工速度等优势,是制备大面积柔性有机太阳能电池(FOSCs)的一种可行技术.有机光活性层的薄膜质量是决定有机太阳能电池器件性能的关键.对于凹版印刷过程而言,墨水的转移是影响印刷薄膜厚度和质量的关键.本文深入研究了有机光活性层的墨水粘度对墨水转移率和薄膜缺陷的影响.我们开发了紫外可见光谱法,量化凹版印刷过程中墨水的转移率.通过对墨水的流变行为分析、流体动力学模拟和实验验证,深入研究了油墨粘度与油墨转移率、膜厚和膜均匀性之间的关系.结果表明,油墨粘度约为25 m Pa·s是R2R凹版印刷有机光活性层薄膜的适合粘度.通过对油墨配方的优化,我们制备了全R2R印刷FOSCs,其中1 cm^(2);电池的效率超过12%.
基金the Sichuan Huotai Pharmaceutical Co.,Ltd under Grant(20200601-1).
文摘Purpose Our purpose was to compare the difference between hot-air dried American ginseng(HDAG)(Panacis Quinquefolii Radix)and freeze-dried American ginseng(FDAG)(Panacis Quinquefolii Radix)and provide a better drying approach for improv-ing the quality of American ginseng(Panacis Quinquefolii Radix).Methods In our present study,we compared the appearance features of HDAG and FDAG using a CR-410 colorimeter and scanning electron microscopy.Furthermore,we qualitatively and quantitatively determined ginsenosides in HDAG and FDAG by using UPLC-Q Exactive Orbitrap-MS/MS and high-performance liquid chromatography.Results Our present results showed that compared to the hot-air drying method,freeze-drying(FD)has obvious advantages in not only good appearances but also higher bioactive constituents for drying the American ginseng(Panacis Quinquefolii Radix).Conclusion FD is beneficial for the retention of ginsenosides in American ginseng(Panacis Quinquefolii Radix)and also helpful for maintaining the bioactive effects of this functional food.
基金the Guangdong Major Project of Basic and Applied Basic Research(Grant No.2020B0301030008)the Natural Science Foundation of China(Grant Nos.11935007 and 11805167)。
文摘We investigate the medium modifications of momentum splitting fraction and groomed jet radius with both dynamical grooming and soft drop algorithms in heavy-ion collisions.In the calculation,the partonic spectrum of initial hard scattering in p+p collisions is provided by the event generator PYTHIA8,and the energy loss of fast parton traversing in a hot/dense quantum-chromodynamic medium is simulated with the linear Boltzmann transport model.We predict the normalized distributions of the groomed jet radiusθ_(g)and momentum splitting fraction z_(g)with the dynamical grooming algorithm in Pb+Pb collisions at(sNN)~(1/2)=5.02 TeV,then compare these quantities in dynamical grooming at a=0.1,with that in soft drop at z_(out)=0.1 andβ=0.It is found that the normalized distribution ratios Pb+Pb/p+p with respect to z_(g)in z_(cut)=0.1,β=0 soft drop case are close to unity,those in a=0.1 dynamical grooming case show enhancement at small z_(g),and Pb+Pb/p+p with respect toθ_(g)in the dynamical grooming case demonstrate weaker modification than those in the soft drop counterparts.We further calculate the groomed jet number averaged momentum splitting fraction_(jets)and averaged groomed jet radius<θ_(g)>_(jets)in p+p and A+A for both grooming cases in three p_T~(ch jet)intervals,and find that the originally generated well balanced groomed jets will become more momentum imbalanced and jet size less narrowed due to jet quenching,and weaker medium modification of z_(g)andθ_(g)in the a=0.1 dynamical grooming case than in the soft drop counterparts.
