抑郁症是最普遍的精神疾病,将成为全球疾病的负担,睡眠障碍也将成为抑郁症患者的隐性杀手。抑郁症与睡眠障碍之间存在着密切的联系,常共同出现。目前临床研究以睡眠和认知功能障碍为研究热点,但受限于科学技术,其机制及影响尚不明确。...抑郁症是最普遍的精神疾病,将成为全球疾病的负担,睡眠障碍也将成为抑郁症患者的隐性杀手。抑郁症与睡眠障碍之间存在着密切的联系,常共同出现。目前临床研究以睡眠和认知功能障碍为研究热点,但受限于科学技术,其机制及影响尚不明确。近年来得益于功能磁共振成像(functional magnetic resonance imaging,fMRI)的发展,许多新的成像方法应运而生,利用神经影像技术观察抑郁伴睡眠障碍的研究也越来越多。本文将从抑郁伴睡眠障碍的核脑影像成像技术进行综述。展开更多
Objective： To provide essential information for peptide inhibitor design, the interactions of Eps15 homology domain of Eps15 homology domain-containing protein 1 （EHD1 EH domain） with three peptides containing NPF ...Objective： To provide essential information for peptide inhibitor design, the interactions of Eps15 homology domain of Eps15 homology domain-containing protein 1 （EHD1 EH domain） with three peptides containing NPF （asparagine-proline-phenylalanine）, DPF （aspartic acid-proline-phenylalanine）, and GPF （glycine-proline-phenylalanine） motifs were deciphered at the atomic level. The binding affinities and the underlying structure basis were investigated. Methods： Molecular dynamics （MD） simulations were performed on EHD1 EH domain/peptide complexes for 60 ns using the GROMACS package. The binding free energies were calculated and decomposed by molecular mechanics/ generalized Born surface area （MM/GBSA） method using the AMBER package. The alanine scanning was performed to evaluate the binding hot spot residues using FoldX software. Results： The different binding affinities for the three peptides were affected dominantly by van der Waals interactions. Intermolecular hydrogen bonds provide the struc- tural basis of contributions of van der Waals interactions of the flanking residues to the binding. Conclusions： van der Waals interactions should be the main consideration when we design peptide inhibitors of EHD1 EH domain with high affinities. The ability to form intermolecular hydrogen bonds with protein residues can be used as the factor for choosing the flanking residues.展开更多
The distribution of energy deposition density in radiate region and its surrounding areas from γ-rays wassimulated and analyzed for a water-ball model with Geant4 package(Geant4.7.0,2005) developed by CERN (theCenter...The distribution of energy deposition density in radiate region and its surrounding areas from γ-rays wassimulated and analyzed for a water-ball model with Geant4 package(Geant4.7.0,2005) developed by CERN (theCenter of European Research of Nucleus). The results show that the distribution depends strongly on the collimatingcondition of radiation beam. A well-collimated beam would reduce radiation effects on surrounding areas.展开更多
Taking into account the combined effects of the external magnetic field, adiabatic dust charge fluctuation and collisions occurring between the charged dust grains and neutral gas particles （dust-neutral collisions）...Taking into account the combined effects of the external magnetic field, adiabatic dust charge fluctuation and collisions occurring between the charged dust grains and neutral gas particles （dust-neutral collisions）, the dust-acoustic solitary waves in three-dimensional uniform dusty plasmas are investigated analytically. By using the reductive perturbation method, the Korteweg-de Vries （KdV） equation governing the dnst-aconstic solitary waves is obtained. The present analytical results show that only rarefactive solitary waves exist in this system. It is also found that the effects of the wave vector along the z-direction, dust charge variation, collisional frequency, the plasma density, and temperature ratio can significantly influence the characteristics of low-frequency wave modes. Moreover, for the collisional dusty plasmas, there is a certain critical value μc of the plasma density ratio μ, if μ 〈 μc, the width of the waves increases with μ, otherwise the width of waves decreases with μ.展开更多
基金supported by the National Natural Science Foundation of China(22171267,21829501,21925303,21701179,21771186,21501181,21222301,and 21528303)Anhui Provincial Natural Science Foundation(2008085MB31 and 2108085MB56)+4 种基金Hefei Institutes of Physical Science,Chinese Academy of Sciences(CASHIPS)Director’s Fund(BJPY2019A02)China Postdoctoral Science Foundation(Y94G4E356B)the Key Program of the 13th Five Year Plan,CASHIPS(KP-2017-16)the Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2020HSC-CIP005 and 2022HSC-CIP018)the CAS/SAFEA International Partnership Program for Creative Research Teams.
基金supported by the National Natural Science Foundation of China(21925303,21829501,21771186,22171267,22171268,21222301,21171170 and 21528303)Anhui Provincial Natural Science Foundation(2008085MB31 and 2108085MB56)+2 种基金the Youth Innovation Promotion Association CAS(2023468)the HFIPS Director’s Fund(BJPY2019A02,YZJJ202102,YZJJ202306-TS and YZJJ-GGZX-2022-01)the Collaborative Innovation Program of Hefei Science Center,CAS(2020HSC-CIP005 and 2022HSC-CIP018).
文摘抑郁症是最普遍的精神疾病,将成为全球疾病的负担,睡眠障碍也将成为抑郁症患者的隐性杀手。抑郁症与睡眠障碍之间存在着密切的联系,常共同出现。目前临床研究以睡眠和认知功能障碍为研究热点,但受限于科学技术,其机制及影响尚不明确。近年来得益于功能磁共振成像(functional magnetic resonance imaging,fMRI)的发展,许多新的成像方法应运而生,利用神经影像技术观察抑郁伴睡眠障碍的研究也越来越多。本文将从抑郁伴睡眠障碍的核脑影像成像技术进行综述。
基金supported by the National Natural Science Foundation of China(Nos.11172259 and 31471807)the Special Fund for Agro-scientific Research in the Public Interest(No.201403030),China
文摘Objective： To provide essential information for peptide inhibitor design, the interactions of Eps15 homology domain of Eps15 homology domain-containing protein 1 （EHD1 EH domain） with three peptides containing NPF （asparagine-proline-phenylalanine）, DPF （aspartic acid-proline-phenylalanine）, and GPF （glycine-proline-phenylalanine） motifs were deciphered at the atomic level. The binding affinities and the underlying structure basis were investigated. Methods： Molecular dynamics （MD） simulations were performed on EHD1 EH domain/peptide complexes for 60 ns using the GROMACS package. The binding free energies were calculated and decomposed by molecular mechanics/ generalized Born surface area （MM/GBSA） method using the AMBER package. The alanine scanning was performed to evaluate the binding hot spot residues using FoldX software. Results： The different binding affinities for the three peptides were affected dominantly by van der Waals interactions. Intermolecular hydrogen bonds provide the struc- tural basis of contributions of van der Waals interactions of the flanking residues to the binding. Conclusions： van der Waals interactions should be the main consideration when we design peptide inhibitors of EHD1 EH domain with high affinities. The ability to form intermolecular hydrogen bonds with protein residues can be used as the factor for choosing the flanking residues.
文摘The distribution of energy deposition density in radiate region and its surrounding areas from γ-rays wassimulated and analyzed for a water-ball model with Geant4 package(Geant4.7.0,2005) developed by CERN (theCenter of European Research of Nucleus). The results show that the distribution depends strongly on the collimatingcondition of radiation beam. A well-collimated beam would reduce radiation effects on surrounding areas.
文摘Taking into account the combined effects of the external magnetic field, adiabatic dust charge fluctuation and collisions occurring between the charged dust grains and neutral gas particles （dust-neutral collisions）, the dust-acoustic solitary waves in three-dimensional uniform dusty plasmas are investigated analytically. By using the reductive perturbation method, the Korteweg-de Vries （KdV） equation governing the dnst-aconstic solitary waves is obtained. The present analytical results show that only rarefactive solitary waves exist in this system. It is also found that the effects of the wave vector along the z-direction, dust charge variation, collisional frequency, the plasma density, and temperature ratio can significantly influence the characteristics of low-frequency wave modes. Moreover, for the collisional dusty plasmas, there is a certain critical value μc of the plasma density ratio μ, if μ 〈 μc, the width of the waves increases with μ, otherwise the width of waves decreases with μ.
