Understanding the normal electronic state is crucial for unveiling the mechanism of unconventional superconductivity(SC). In this paper, by applying a magnetic field of up to 37T on FeSe single crystals, we could reve...Understanding the normal electronic state is crucial for unveiling the mechanism of unconventional superconductivity(SC). In this paper, by applying a magnetic field of up to 37T on FeSe single crystals, we could reveal the normal-state transport properties after SC was completely suppressed. The normal-state resistivity exhibited a Fermi liquid behavior at low temperatures. Large orbital magnetoresistance(MR) was observed in the nematic state with H//c, whereas MR was negligible with H//ab. The magnitude of the orbital MR showed an unusual reduction, and Kohler’s rule was severely violated below 10-25 K;these were attributable to spin fluctuations. The results indicated that spin fluctuations played a paramount role in the normalstate transport properties of FeSe albeit the Fermi liquid nature was at low temperature.展开更多
The present study here establishes a complete and effective method for isolating,purifying and identifying extracellular and intracellular peptides,and also describes the characters and bioactivities of peptides from ...The present study here establishes a complete and effective method for isolating,purifying and identifying extracellular and intracellular peptides,and also describes the characters and bioactivities of peptides from fermented casein with Lactobacillus helveticus.Intracellular peptides are much larger in quantity and more complex in composition than extracellular peptides,between which the correlation reveals proteolytic and metabolic mechanisms.In addition,totally 241 different peptide sequences were identified by Nano LC–MS/MS from casein(212)and Lactobacillus helveticus proteins(29).These casein-derived peptides mostly originated from-casein,followed byS1-casein,-casein,andS2-casein,and came from extracell(69)and intracell(143),in which common peptides have a total of 27.Forty-four of the identified peptides were previously described as bioactive,including angiotensinconverting enzyme(ACE)-inhibitory,antioxidant,immunomodulating,antimicrobial,DPP-IV inhibitory,antiamnesic and anticancer effects and so on.Thirteen peptides with the potential of some biological activities are obtained,which were described in previous studies.A total of 47 novel peptides of 5 to 26 amino acids that were not disclosed were obtained.The new sources of natural bioactive peptides may have the very high application value as potential new peptide drugs for treatment human diseases.The product peptide DELQDKIHPF found in both extracell and intracell was quantitatively analyzed using the MRM mode of UPLC-U3Q,23.1 and 9.76 ng/mL,respectively.The quantitative analysis of the potential bioactive peptide may also advance the production of peptide products in the future.展开更多
The correlation of surface impurity states with the antiferromagnetic ground states is crucial for understanding the formation of the topological surface state in the antiferromagnetic topological insulators MnBi_(2)T...The correlation of surface impurity states with the antiferromagnetic ground states is crucial for understanding the formation of the topological surface state in the antiferromagnetic topological insulators MnBi_(2)Te_(4).By using low-temperature scanning tunneling microscopy and spectroscopy,we observed a localized bound state around the Mn-Bi antisite defect at the Teterminated surface of the antiferromagnetic topological insulator MnBi_(2)Te_(4).When applying a magnetic field perpendicular to the surface(Bz)from–1.5 to 3.0 T,the bound state shifts linearly to a lower energy with increasing Bz,which is attributed to the Zeeman effect.Remarkably,when applying a large range of Bz from–8.0 to 8.0 T,the magnetic field induced reorientation of surface magnetic moments results in an abrupt jump in the local density of states(LDOS),which is characterized by LDOSchange-ratio■quantitatively.Interestingly,two asymmetric critical field,–2.0 and 4.0 T determined by the two peaks in■are observed,which is consistent with simulated results according to a Mills-model,describing a surface spin flop transition(SSF).Our results provide a new flatform for studying the interplay between magnetic order and topological phases in magnetic topological materials.展开更多
Objective:To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate(DAC)managed with radical prostatectomy(RP)or radiotherapy(RT)and optimize the proper treatment modality to DAC comprehensively.Me...Objective:To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate(DAC)managed with radical prostatectomy(RP)or radiotherapy(RT)and optimize the proper treatment modality to DAC comprehensively.Methods:The cohorts included a total of 528 patients from the Surveillance,Epidemiology and End Results(SEER)database,354 receiving RP and 174 receiving RT.Cox proportional hazards regressions were performed to assess cancer specific mortality(CSM)and overall mortality(OM)between treatment groups.A competing risk analysis was further conducted.Subgroup analyses by age and level of prostate-specific antigen(PSA)were performed.Propensity score matching was implemented.Results:Patients managed with RP had lower risks of CSM and OM compared with RT(before matching:Hazard ratio[HR]=0.24,95%confidence interval[CI]0.13-0.47 and HR=0.26,95%CI 0.17-0.40,respectively;after matching:HR=0.18,95%CI 0.04-0.82 and HR=0.28,95%CI 0.11-0.70,accordingly).Subgroup analyses demonstrated that patients in the middle tertile of the age or with lower tertile PSA level managed with RP took lower risks of OM significantly(HR=0.18,95%CI 0.06-0.57,p<0.01 and HR=0.17,95%CI 0.06-0.54,p<0.01).Conclusion:Among patients with DAC,treatment with RP was associated with better survival outcomes in comparison with RT.Patients with DAC in the middle tertile of the age and with lower tertile PSA level benefited the most from RP.展开更多
We report the synthesis,structural and physical properties of a new layered transition metal arsenide Na4Cu3TaAs4.This material adopts the space groupⅠ√2 m,with lattice parameters of a=5.9101(3)?and c=13.8867(12)?.T...We report the synthesis,structural and physical properties of a new layered transition metal arsenide Na4Cu3TaAs4.This material adopts the space groupⅠ√2 m,with lattice parameters of a=5.9101(3)?and c=13.8867(12)?.This structure contains two layers of Na sandwiched by antiPb O-type(Cu/Ta)As layers,similar to the"111"-type ironbased superconductor Na Fe As.The transition metal sites are occupied by 75%Cu and 25%Ta,with Ta forming a well-defined superstructure.Cu and Ta were determined to be+1 and+5 oxidation state respectively.The band structure of the Na4Cu3TaAs4 measured by angle resolved photoemission spectroscopy(ARPES)is in good agreement with the density functional theory(DFT)calculation.Both ARPES and resistivity measurement indicate that this material exhibits metallic behavior with p-type carriers.Magnetic susceptibility measurement shows that the material exhibits nearly T-independent diamagnetism.This new material extends the material system with anti-Pb O-type layers and offers a good playground to investigate this material system further.展开更多
Superconductivity at the 2D limit shows emergent novel quantum phenomena, including anomalously enhanced H_(c2),quantum metallic states and quantum Griffiths singularity, which has attracted much attention in the fiel...Superconductivity at the 2D limit shows emergent novel quantum phenomena, including anomalously enhanced H_(c2),quantum metallic states and quantum Griffiths singularity, which has attracted much attention in the field of condensed matter physics. In this article, we focus on new advances in quasi-2D superconductors in the bulk phase using an organic molecular electrochemical intercalation method. The enhanced superconductivity and emergent pseudogap behavior in these quasi-2D superconductors are summarized with a further prospect.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.11888101,and 11534010)the National Key Research and Development Program of the Ministry of Science and Technology of China(Grant Nos.2019YFA0704900,2016YFA0300201,and 2017YFA0303001)+6 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(CAS)(Grant No.XDB25000000)Anhui Initiative in Quantum Information Technologies(Grant No.AHY160000)the Science Challenge Project of China(Grant No.TZ2016004)the Key Research Program of Frontier SciencesCASChina(Grant No.QYZDYSSWSLH021)the Fundamental Research Funds for the Central Universities(Grant Nos.WK3510000011,and WK2030020031)。
文摘Understanding the normal electronic state is crucial for unveiling the mechanism of unconventional superconductivity(SC). In this paper, by applying a magnetic field of up to 37T on FeSe single crystals, we could reveal the normal-state transport properties after SC was completely suppressed. The normal-state resistivity exhibited a Fermi liquid behavior at low temperatures. Large orbital magnetoresistance(MR) was observed in the nematic state with H//c, whereas MR was negligible with H//ab. The magnitude of the orbital MR showed an unusual reduction, and Kohler’s rule was severely violated below 10-25 K;these were attributable to spin fluctuations. The results indicated that spin fluctuations played a paramount role in the normalstate transport properties of FeSe albeit the Fermi liquid nature was at low temperature.
文摘The present study here establishes a complete and effective method for isolating,purifying and identifying extracellular and intracellular peptides,and also describes the characters and bioactivities of peptides from fermented casein with Lactobacillus helveticus.Intracellular peptides are much larger in quantity and more complex in composition than extracellular peptides,between which the correlation reveals proteolytic and metabolic mechanisms.In addition,totally 241 different peptide sequences were identified by Nano LC–MS/MS from casein(212)and Lactobacillus helveticus proteins(29).These casein-derived peptides mostly originated from-casein,followed byS1-casein,-casein,andS2-casein,and came from extracell(69)and intracell(143),in which common peptides have a total of 27.Forty-four of the identified peptides were previously described as bioactive,including angiotensinconverting enzyme(ACE)-inhibitory,antioxidant,immunomodulating,antimicrobial,DPP-IV inhibitory,antiamnesic and anticancer effects and so on.Thirteen peptides with the potential of some biological activities are obtained,which were described in previous studies.A total of 47 novel peptides of 5 to 26 amino acids that were not disclosed were obtained.The new sources of natural bioactive peptides may have the very high application value as potential new peptide drugs for treatment human diseases.The product peptide DELQDKIHPF found in both extracell and intracell was quantitatively analyzed using the MRM mode of UPLC-U3Q,23.1 and 9.76 ng/mL,respectively.The quantitative analysis of the potential bioactive peptide may also advance the production of peptide products in the future.
基金supported by the National Natural Science Foundation of China (12264052)the Science and Technology Research Project of Jiangxi Provincial Department of Education (GJJ211607)。
基金This work is supported by the National Natural Science Foundation of China(Nos.61888102 and 52022105)National Key Research and Development Projects of China(Nos.2018YFA0305800 and 2019YFA0308500)+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Nos.XDB30000000 and XDB28000000)CAS Project for Young Scientists in Basic Research(No.YSBR-003)the University of Chinese Academy of Sciences.
文摘The correlation of surface impurity states with the antiferromagnetic ground states is crucial for understanding the formation of the topological surface state in the antiferromagnetic topological insulators MnBi_(2)Te_(4).By using low-temperature scanning tunneling microscopy and spectroscopy,we observed a localized bound state around the Mn-Bi antisite defect at the Teterminated surface of the antiferromagnetic topological insulator MnBi_(2)Te_(4).When applying a magnetic field perpendicular to the surface(Bz)from–1.5 to 3.0 T,the bound state shifts linearly to a lower energy with increasing Bz,which is attributed to the Zeeman effect.Remarkably,when applying a large range of Bz from–8.0 to 8.0 T,the magnetic field induced reorientation of surface magnetic moments results in an abrupt jump in the local density of states(LDOS),which is characterized by LDOSchange-ratio■quantitatively.Interestingly,two asymmetric critical field,–2.0 and 4.0 T determined by the two peaks in■are observed,which is consistent with simulated results according to a Mills-model,describing a surface spin flop transition(SSF).Our results provide a new flatform for studying the interplay between magnetic order and topological phases in magnetic topological materials.
基金supported by the National Key Research and Development Program of China(Grant No.SQ2017YFC0908003)National Natural Science Foundation of China(Grant No.81702536,81770756)+3 种基金the Sichuan Science and Technology Program(2017HH0063)China Postdoctoral Science Foundation(2017M612971)Post-Doctor Research Project,West China Hospital,Sichuan University(2018HXBH085)National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(Z2018C01).
文摘Objective:To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate(DAC)managed with radical prostatectomy(RP)or radiotherapy(RT)and optimize the proper treatment modality to DAC comprehensively.Methods:The cohorts included a total of 528 patients from the Surveillance,Epidemiology and End Results(SEER)database,354 receiving RP and 174 receiving RT.Cox proportional hazards regressions were performed to assess cancer specific mortality(CSM)and overall mortality(OM)between treatment groups.A competing risk analysis was further conducted.Subgroup analyses by age and level of prostate-specific antigen(PSA)were performed.Propensity score matching was implemented.Results:Patients managed with RP had lower risks of CSM and OM compared with RT(before matching:Hazard ratio[HR]=0.24,95%confidence interval[CI]0.13-0.47 and HR=0.26,95%CI 0.17-0.40,respectively;after matching:HR=0.18,95%CI 0.04-0.82 and HR=0.28,95%CI 0.11-0.70,accordingly).Subgroup analyses demonstrated that patients in the middle tertile of the age or with lower tertile PSA level managed with RP took lower risks of OM significantly(HR=0.18,95%CI 0.06-0.57,p<0.01 and HR=0.17,95%CI 0.06-0.54,p<0.01).Conclusion:Among patients with DAC,treatment with RP was associated with better survival outcomes in comparison with RT.Patients with DAC in the middle tertile of the age and with lower tertile PSA level benefited the most from RP.
基金supported by the National Natural Science Foundation of China(11888101 and 11534010)Anhui Initiative in Quantum Information Technologies(AHY160000)+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(XDB25000000)the National Key Research and Development Program of the Ministry of Science and Technology of China(2016YFA0300201 and 2017YFA0303001)the Key Research Program of Frontier Sciences,CAS,China(QYZDYSSW-SLH021).
文摘We report the synthesis,structural and physical properties of a new layered transition metal arsenide Na4Cu3TaAs4.This material adopts the space groupⅠ√2 m,with lattice parameters of a=5.9101(3)?and c=13.8867(12)?.This structure contains two layers of Na sandwiched by antiPb O-type(Cu/Ta)As layers,similar to the"111"-type ironbased superconductor Na Fe As.The transition metal sites are occupied by 75%Cu and 25%Ta,with Ta forming a well-defined superstructure.Cu and Ta were determined to be+1 and+5 oxidation state respectively.The band structure of the Na4Cu3TaAs4 measured by angle resolved photoemission spectroscopy(ARPES)is in good agreement with the density functional theory(DFT)calculation.Both ARPES and resistivity measurement indicate that this material exhibits metallic behavior with p-type carriers.Magnetic susceptibility measurement shows that the material exhibits nearly T-independent diamagnetism.This new material extends the material system with anti-Pb O-type layers and offers a good playground to investigate this material system further.
基金Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB25000000)the National Natural Science Foundation of China (Grant No. 11888101)+2 种基金the National Key R&D Program of China (Grant No. 2017YFA0303001)the Anhui Initiative in Quantum Information Technologies, China (Grant No. AHY160000)the Key Research Program of Frontier Sciences, CAS (Grant No. QYZDYSSW-SLH021)。
文摘Superconductivity at the 2D limit shows emergent novel quantum phenomena, including anomalously enhanced H_(c2),quantum metallic states and quantum Griffiths singularity, which has attracted much attention in the field of condensed matter physics. In this article, we focus on new advances in quasi-2D superconductors in the bulk phase using an organic molecular electrochemical intercalation method. The enhanced superconductivity and emergent pseudogap behavior in these quasi-2D superconductors are summarized with a further prospect.
