In this work,the microstructural evolution and mechanical properties of a pre-deformed WE43 magnesium alloy when aged at 250 and 300℃ were further investigated.It is found that the abundant deformation twins introduc...In this work,the microstructural evolution and mechanical properties of a pre-deformed WE43 magnesium alloy when aged at 250 and 300℃ were further investigated.It is found that the abundant deformation twins introduced by pre-deformation were maintained within the alloy during the aging treatment.Second particles formed at the twin boundaries and coarsened with aging time,especially at 300℃.When peak-aged at 250℃,the fine metastable β'''and β' precipitates formed in the un-deformed alloy have been transformed into relatively large β1 and β precipitates by the pre-deformation.While peak-aged at 300℃,the pre-deformation obviously refined the β precipitates.Mechanical properties indicate that pre-deformation can increase the yield strength by 19MPa and 54MPa for the peak-aged alloy at 250℃ and 300℃,respectively,and will not obviously deteriorate the tensile elongations.展开更多
A sub-array of the Large High Altitude Air Shower Observatory(LHAASO),KM2A is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 TeV.Even though the detecto...A sub-array of the Large High Altitude Air Shower Observatory(LHAASO),KM2A is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 TeV.Even though the detector construction is still underway,half of the KM2A array has been operating stably since the end of 2019.In this paper,we present the KM2A data analysis pipeline and the first observation of the Crab Nebula,a standard candle in very high energy γ-ray astronomy.We detect γ-ray signals from the Crab Nebula in both energy ranges of 10-100 TeV and>100 TeV with high significance,by analyzing the KM2A data of 136 live days between December 2019 and May 2020.With the observations,we test the detector performance,including angular resolution,pointing accuracy and cosmic-ray background rejection power.The energy spectrum of the Crab Nebula in the energy range 10-250 TeV fits well with a single power-law function dN/dE=(1.13±0.05stat±0.08sys)×10^(-14).(E/20 TeV)-309±0.06stat±0.02syscm^(-2) s^(-1) TeV^(-1).It is consistent with previous measurements by other experiments.This opens a new window of γ-ray astronomy above 0.1 PeV through which new ultrahigh-energy γ-ray phenomena,such as cosmic PeVatrons,might be discovered.展开更多
Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor receptor(EGFR)gene were among the first EGFR mutations to be identified as oncogenic drivers in non-small cell lung cancer(NSCLC...Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor receptor(EGFR)gene were among the first EGFR mutations to be identified as oncogenic drivers in non-small cell lung cancer(NSCLC).However,unlike the classical EGFR L858R point mutation or exon 19 deletions,which represent the majority of EGFR mutations in NSCLC,low frequency EGFR exon 20 insertion mutations are associated with de novo resistance to targeted EGFR inhibitors and correlate with a poor patient prognosis.Here,we review the developments over the last 5 years in which pre-clinical studies,including elucidation of the crystal structure of an EGFR exon 20 insertion mutant kinase,have revealed a unique mechanism of kinase activation and steric conformation that define the lack of response of these EGFR mutations to clinically approved EGFR inhibitors.The recent development of several novel small molecule compounds that selectively inhibit EGFR exon 20 insertions holds promise for future therapeutic options that will be effective for patients with this molecular subtype of NSCLC.展开更多
The full array of the Large High Altitude Air Shower Observatory(LHAASO)has been in operation since July 2021.For its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energy...The full array of the Large High Altitude Air Shower Observatory(LHAASO)has been in operation since July 2021.For its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous cuts.With the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of TeV.Other aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab Nebula.The resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from LHAASO and other experiments.展开更多
The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field X-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on20...The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field X-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on2022 July 27.In this paper,we introduce the design and on-ground test results of the LEIA instrument.Using stateof-the-art Micro-Pore Optics(MPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the X-ray imager is realized.An optical assembly composed of 36 MPO chips is used to focus incident X-ray photons,and four large-format complementary metal-oxide semiconductor(CMOS)sensors,each of size 6 cm×6 cm,are used as the focal plane detectors.The instrument has an angular resolution of 4’-8’(in terms of FWHM)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of view.The detection passband is 0.5-4 keV in soft X-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 milliCrab)with a 1000 s observation.The total weight of LEIA is 56 kg and the power is 85 W.The satellite,with a design lifetime of 2 yr,operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 minutes.LEIA is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CMOS sensors for X-ray observation,and by optimizing the working setups of the instrumental parameters.In addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft X-ray band,albeit with limited useful observing time available.展开更多
Conventionally, metallic nanostructures are used for surface-enhanced Raman spectroscopy(SERS), but recently there has been increasing interest in the enhancement of Raman scattering from dielectric substrates due to ...Conventionally, metallic nanostructures are used for surface-enhanced Raman spectroscopy(SERS), but recently there has been increasing interest in the enhancement of Raman scattering from dielectric substrates due to their improved stability and biocompatibility compared with metallic substrates. Here, we report the observation of enhanced Raman scattering from rhodamine 6 G molecules coated on silica microspheres. We excite the whispering gallery modes(WGMs) supported in the microspheres with a tapered fiber coupler for efficient WGM excitation, and the Raman enhancement can be attributed to the WGM mechanism. Strong resonance enhancement in pump laser intensity and modified Raman emission from the Purcell effect in the microsphere resonator are observed from the experiment and compared with theoretical results. A total Raman enhancement factor of 1.4 × 10~4 is observed, with contribution mostly from the enhancement in pump laser intensity. Our results show that, with an efficient pumping scheme, dielectric microspheres are a viable alternative to metallic SERS substrates.展开更多
The first Water Cherenkov detector of the LHAASO experiment(WCDA-1)has been operating since April 2019.The data for the first year have been analyzed to test its performance by observing the Crab Nebula as a standard ...The first Water Cherenkov detector of the LHAASO experiment(WCDA-1)has been operating since April 2019.The data for the first year have been analyzed to test its performance by observing the Crab Nebula as a standard candle.The WCDA-1 achieves a sensitivity of 65 mCU per year,with a statistical threshold of 5 cr.To accomplish this,a 97.7%cosmic-ray background rejection rate around 1 TeV and 99.8%around 6 TeV with an ap proximate photon acceptance of 50%is achieved after applying an algorithm to separate gamma-induced showers.The angular resolution is measured using the Crab Nebula as a point source to be approximately 0.45°at 1 TeV and better than 0.2°above 6 TeV,with a pointing accuracy better than 0.05°.These values all match the design specifications.The energy resolution is found to be 33%for gamma rays around 6 TeV.The spectral energy distribution of the Crab Nebula in the range from 500 GeV to 15.8 TeV is measured and found to be in agreement with the results from other TeV gamma ray observatories.展开更多
The Large High Altitude Air Shower Observatory(LHAASO)has three sub-arrays,KM2A,WCDA,and WFCTA.The flux variations of cosmic ray air showers were studied by analyzing the KM2A data during a thunderstorm on June 10,202...The Large High Altitude Air Shower Observatory(LHAASO)has three sub-arrays,KM2A,WCDA,and WFCTA.The flux variations of cosmic ray air showers were studied by analyzing the KM2A data during a thunderstorm on June 10,2021.The number of shower events that meet the trigger conditions increases significantly in atmospheric electric fields,with a maximum fractional increase of 20%.The variations in trigger rates(increases or decreases)were found to be strongly dependent on the primary zenith angle.The flux of secondary particles increased significantly,following a trend similar to that of shower events.To better understand the observed behavior,Monte Carlo simulations were performed with CORSIKA and G4KM2A(a code based on GEANT4).We found that the experimental data(in saturated negative fields)were in good agreement with the simulations,assuming the presence of a uniform electric field of-700 V/cm with a thickness of 1500 m in the atmosphere above the observation level.Due to the acceleration/deceleration by the atmospheric electric field,the number of secondary particles with energy above the detector threshold was modified,resulting in the changes in shower detection rate.展开更多
As-cast and corrosive microstructures of AZ91D alloy containing various Ce contents were observed by optical microscope (OM). The phase compositions of the alloys before and after the corrosion were analyzed by X-ray ...As-cast and corrosive microstructures of AZ91D alloy containing various Ce contents were observed by optical microscope (OM). The phase compositions of the alloys before and after the corrosion were analyzed by X-ray diffraction (XRD). Meanwhile, the corrosion resistance of the alloys was tested by weight loss and potentiodynamic polarization curve methods respectively. The results show that rod-like Al4Ce phase is formed in AZ91D alloy containing certain Ce content and as-cast microstructures are refined. AZ91D-0.7%Ce alloy has good grain refinement effect. The addition of Ce can reduce the corrosion rate and corrosion current density of AZ91D alloy and those of AZ91D-0.1%Ce alloy reach the minimum, which are 0.35mg/(cm2·d) and 2.761μA/cm2 with 75% and 86% reduction, respectively. The increasing volume fraction and reticular degree of β phase can improve the corrosion resistance of the alloys.展开更多
Introduction One of main scientific goals of the Large High Altitude Air Shower Observatory(LHAASO)is to accurately measure the energy spectra of different cosmic ray compositions around the‘knee’region.The Wide Fiel...Introduction One of main scientific goals of the Large High Altitude Air Shower Observatory(LHAASO)is to accurately measure the energy spectra of different cosmic ray compositions around the‘knee’region.The Wide Field-of-View(FoV)Cherenkov Telescope Array(WFCTA),which is one of the main detectors of LHAASO and has 18 telescopes,is built to achieve this goal.Multiple telescopes are put together and point to connected directions for a larger FoV.Method Telescopes are deployed spatially as close as possible,but due to their own size,the distance between two adjacent telescopes is about 10 m.Therefore,the Cherenkov lateral distribution and the parallax between the two telescopes should be considered in the event building process for images crossing over the boundaries of FoVs of the telescopes.An event building method for Cherenkov images measured by multiple telescopes of WFCTA is developed.The performance of the shower measurements using the combined images is evaluated by comparing with showers that are fully contained by a virtual telescope in simulation.Results and conclusion It is proved that the developed event building process can help to increase the FoV of WFCTA by 30%while maintaining the same reconstruction quality,compared to the separate telescope reconstruction method.展开更多
The LHAASO-WFCTA experiment,which aims to observe cosmic rays in the sub-EeV range using the fluorescence technique,uses a new generation of high-performance telescopes.To ensure that the experiment has ex-cellent det...The LHAASO-WFCTA experiment,which aims to observe cosmic rays in the sub-EeV range using the fluorescence technique,uses a new generation of high-performance telescopes.To ensure that the experiment has ex-cellent detection capability associated with the measurement of the energy spectrum,the primary composition of cosmic rays,and so on,an accurate geometrical reconstruction of air-shower events is fundamental.This paper de-scribes the development and testing of geometrical reconstruction for stereo viewed events using the WFCTA(Wide Field of view Cherenkov/Fluorescence Telescope Array)detectors.Two approaches,which take full advantage ofthe WFCTA detectors.are investigated.One is the stereo-angular method,which uses the pointing of triggered SiPMs in the shower trajectory,and the other is the stereo-timing method,which uses the triggering time of the fired SiPMs.The results show that both methods have good geometrical resolution:the resolution of the stereo-timing method is slightly better than the stereo-angular method because the resolution of the latter is slightly limited by the shower track length.展开更多
The Water Cherenkov Detector Array(WCDA) is a major component of the Large High Altitude Air Shower Array Observatory(LHAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under con...The Water Cherenkov Detector Array(WCDA) is a major component of the Large High Altitude Air Shower Array Observatory(LHAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under construction. WCDA is aimed at the study of TeV γ-rays. In order to evaluate the prospects of searching for TeV γ-ray sources with WCDA, we present a projection of the one-year sensitivity of WCDA to TeV γ-ray sources from TeVCat using an all-sky approach. Out of 128 TeVCat sources observable by WCDA up to a zenith angle of 45°, we estimate that 42 would be detectable in one year of observations at a median energy of 1 TeV. Most of them are Galactic sources, and the extragalactic sources are Active Galactic Nuclei(AGN).展开更多
Purpose The main scientific goal of LHAASO-WCDA is to survey gamma-ray sources with energy from 100 GeV to 30 TeV.To observe high-energy shower events,especially to measure the energy spectrum of cosmic rays from 100 ...Purpose The main scientific goal of LHAASO-WCDA is to survey gamma-ray sources with energy from 100 GeV to 30 TeV.To observe high-energy shower events,especially to measure the energy spectrum of cosmic rays from 100 TeV to 10 PeV,a dynamic range extension system(WCDA++)is designed to use a 1.5-inch PMT with a dynamic range of four orders of magnitude for each cell in WCDA-1.Method The dynamic range is extended by using these PMTs to measure the effective charge density in the core region of air shower events,which is an important parameter for identifying the composition of primary particles.Result and Conclusion The system has been running for more than one year.In this paper,the details of the design and performance of WCDA++are presented.展开更多
Purpose Observation of high energy and very high emission from Gamma Ray Bursts(GRBs)is crucial to study the gigantic explosion and the underline processes.With a large field-of-view and almost full duty cycle,the Wat...Purpose Observation of high energy and very high emission from Gamma Ray Bursts(GRBs)is crucial to study the gigantic explosion and the underline processes.With a large field-of-view and almost full duty cycle,the Water Cherenkov Detector Array(WCDA),a sub-array of the Large High Altitude Air Shower Observatory(LHAASO),is appropriate to monitor the very high energy emission from unpredictable transients such as GRBs.Method Nevertheless,the main issue for an extensive air shower array is the high energy threshold which limits the horizon of the detector.To address this issue a new trigger method is developed in this article to lower the energy threshold of WCDA for GRB observation.Result The proposed method significantly improves the detection efficiency of WCDA for gamma-rays around the GRB direction at 10-300 GeV.The sensitivity of the WCDA for GRB detection with the new trigger method is estimated.The achieved sensitivity of the quarter WCDA array above 10 GeV is comparable with that of Fermi-LAT.The data analysis process and corresponding fluence upper limit for GRB 190719C is presented as an example.展开更多
Each year approximately 360,000 people in the United States suffer a peripheral nerve injury （PNI）, which is a leading source of lifelong disability （Kelsey et al., 1997; Noble et al., 1998）. The most frequent cau...Each year approximately 360,000 people in the United States suffer a peripheral nerve injury （PNI）, which is a leading source of lifelong disability （Kelsey et al., 1997; Noble et al., 1998）. The most frequent cause of PNIs is motor vehicle accidents, while gunshot wounds, stabbings, and birth trauma are also common factors. Patients suffering from disabilities as a result of their PNIs are also burdensome to the healthcare system, with aver- age hospital stays of 28 days each year （Kelsey et al., 1997; Noble et al., 1998）.展开更多
Objective: To compare the short-time complications associated with time-opening suprapubic catheter (SPT) versus intermittent catheter (IC) in male patients with spinal cord injury (above level C5). Methods: A prospec...Objective: To compare the short-time complications associated with time-opening suprapubic catheter (SPT) versus intermittent catheter (IC) in male patients with spinal cord injury (above level C5). Methods: A prospective review of records was carried out to identify SCI patients managed with SPT or IC between 2011 and 2016. The complications included renal function (Serum creatinine), urinary tract infection (UTI), bladder stones, urethral complications, scrotal, and gross hematuria. Patients were followed at week 4, 3 and 6 months;the urodynamic assessment was repeated at 6 months. Results: A total of 30 patients (11 SPT, 19 IC) were recruited in this trial. There is no significant difference between the two catheter groups for the entire out-come. Scrotal abscesses and urethral stricture were only seen in patients with IC. Conclusions: SPT has similar urological complication with IC for SCI patients (above level C5) except the incidence of scrotal abscesses and urethral stricture.展开更多
The microwave absorbents of Fe and C nanoparticles as magnetic loss and dielectric loss material respectively were composited with the polyvinyl alcohol （PVA） as binder by spray granulation method, The electromagnet...The microwave absorbents of Fe and C nanoparticles as magnetic loss and dielectric loss material respectively were composited with the polyvinyl alcohol （PVA） as binder by spray granulation method, The electromagnetic parameters of Fe and C composite particles were analyzed by vector network. The complex permittivity and magnetic permeability of Fe and C composite particles matched well with increasing C nanoparticle content, and then the microwave loss property was improved. A minimum reflection loss （RL） of -42.7 dB at 3.68 GHz for a composite with 4.6 mm in thickness can be obtained when the content ratio of the C nanoparticles, the modified Fe nanoparticles and the PVA is 21：49：30 （Sample 3）.展开更多
Nano brazing of Pt-Ag nanoparticles with nano Ag filler metal is reported in this letter, which presents an effective way to join nanoobjects by femtosecond laser irradiation. The nano brazed interface between Pt-Ag a...Nano brazing of Pt-Ag nanoparticles with nano Ag filler metal is reported in this letter, which presents an effective way to join nanoobjects by femtosecond laser irradiation. The nano brazed interface between Pt-Ag and Ag showed good lattice matching along(111)_(Ag) //(111)_(Ag-Pt). Lattice mismatch can hardly be observed at the interface between the filler metal and Pt-Ag nanoparticle, which is important for the joint strength and normally does not occur during joining. The very low mismatch also suggested that melting and solidification occurred during nano brazing by femtosecond laser. The role of Brownian motion on the nano joining process is also discussed in this paper.展开更多
基金We thank the GDAS’Project of Science and Technology Development(Grants No.2018GDASCX0966,2019GDASYL-0203002,2018GDASCX-0117)Guangzhou Science and Technology Planning Project(Grant No.201904010309)for the financial support.
文摘In this work,the microstructural evolution and mechanical properties of a pre-deformed WE43 magnesium alloy when aged at 250 and 300℃ were further investigated.It is found that the abundant deformation twins introduced by pre-deformation were maintained within the alloy during the aging treatment.Second particles formed at the twin boundaries and coarsened with aging time,especially at 300℃.When peak-aged at 250℃,the fine metastable β'''and β' precipitates formed in the un-deformed alloy have been transformed into relatively large β1 and β precipitates by the pre-deformation.While peak-aged at 300℃,the pre-deformation obviously refined the β precipitates.Mechanical properties indicate that pre-deformation can increase the yield strength by 19MPa and 54MPa for the peak-aged alloy at 250℃ and 300℃,respectively,and will not obviously deteriorate the tensile elongations.
基金Supported in China by National Key R&D program of China under the grants(2018YF A0404201.2018YFA0404202.2018YF A0404203)by NSFC(12022502,190527,135011,11761141001.U1931112,11775131,U1931201,11905043,U1931108)by NSFSPC(ZR2019MA014),and in Thailand by RTA6280002 from Thailand Science Research and Innovation。
文摘A sub-array of the Large High Altitude Air Shower Observatory(LHAASO),KM2A is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 TeV.Even though the detector construction is still underway,half of the KM2A array has been operating stably since the end of 2019.In this paper,we present the KM2A data analysis pipeline and the first observation of the Crab Nebula,a standard candle in very high energy γ-ray astronomy.We detect γ-ray signals from the Crab Nebula in both energy ranges of 10-100 TeV and>100 TeV with high significance,by analyzing the KM2A data of 136 live days between December 2019 and May 2020.With the observations,we test the detector performance,including angular resolution,pointing accuracy and cosmic-ray background rejection power.The energy spectrum of the Crab Nebula in the energy range 10-250 TeV fits well with a single power-law function dN/dE=(1.13±0.05stat±0.08sys)×10^(-14).(E/20 TeV)-309±0.06stat±0.02syscm^(-2) s^(-1) TeV^(-1).It is consistent with previous measurements by other experiments.This opens a new window of γ-ray astronomy above 0.1 PeV through which new ultrahigh-energy γ-ray phenomena,such as cosmic PeVatrons,might be discovered.
文摘Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor receptor(EGFR)gene were among the first EGFR mutations to be identified as oncogenic drivers in non-small cell lung cancer(NSCLC).However,unlike the classical EGFR L858R point mutation or exon 19 deletions,which represent the majority of EGFR mutations in NSCLC,low frequency EGFR exon 20 insertion mutations are associated with de novo resistance to targeted EGFR inhibitors and correlate with a poor patient prognosis.Here,we review the developments over the last 5 years in which pre-clinical studies,including elucidation of the crystal structure of an EGFR exon 20 insertion mutant kinase,have revealed a unique mechanism of kinase activation and steric conformation that define the lack of response of these EGFR mutations to clinically approved EGFR inhibitors.The recent development of several novel small molecule compounds that selectively inhibit EGFR exon 20 insertions holds promise for future therapeutic options that will be effective for patients with this molecular subtype of NSCLC.
基金Supported by the National Key R&D Program of China(2018YFA0404201,2018YFA0404202,2018YFA0404203,2018YFA0404204)the National Natural Science Foundation of China(12022502,12205314,12105301,12261160362,12105294,U1931201)+2 种基金the Youth Innovation Promotion Association CAS(2022010)in Thailand by the National Science and Technology Development Agency(NSTDA)the National Research Council of Thailand(NRCT):High-Potential Research Team Grant Program(N42A650868)。
文摘The full array of the Large High Altitude Air Shower Observatory(LHAASO)has been in operation since July 2021.For its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous cuts.With the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of TeV.Other aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab Nebula.The resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from LHAASO and other experiments.
基金supported by the Einstein Probe project,a mission in the Strategic Priority Program on Space Science of CAS(grant Nos.XDA15310000,XDA15052100)in part been supported by the European Union’s Horizon 2020 Program under the AHEAD2020 project(grant No.871158).
文摘The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field X-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on2022 July 27.In this paper,we introduce the design and on-ground test results of the LEIA instrument.Using stateof-the-art Micro-Pore Optics(MPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the X-ray imager is realized.An optical assembly composed of 36 MPO chips is used to focus incident X-ray photons,and four large-format complementary metal-oxide semiconductor(CMOS)sensors,each of size 6 cm×6 cm,are used as the focal plane detectors.The instrument has an angular resolution of 4’-8’(in terms of FWHM)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of view.The detection passband is 0.5-4 keV in soft X-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 milliCrab)with a 1000 s observation.The total weight of LEIA is 56 kg and the power is 85 W.The satellite,with a design lifetime of 2 yr,operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 minutes.LEIA is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CMOS sensors for X-ray observation,and by optimizing the working setups of the instrumental parameters.In addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft X-ray band,albeit with limited useful observing time available.
基金National Science Foundation(NSF)(CBET1264750,CBET 1264997)Army Research Office(ARO)(W911NF-16-1-0339)
文摘Conventionally, metallic nanostructures are used for surface-enhanced Raman spectroscopy(SERS), but recently there has been increasing interest in the enhancement of Raman scattering from dielectric substrates due to their improved stability and biocompatibility compared with metallic substrates. Here, we report the observation of enhanced Raman scattering from rhodamine 6 G molecules coated on silica microspheres. We excite the whispering gallery modes(WGMs) supported in the microspheres with a tapered fiber coupler for efficient WGM excitation, and the Raman enhancement can be attributed to the WGM mechanism. Strong resonance enhancement in pump laser intensity and modified Raman emission from the Purcell effect in the microsphere resonator are observed from the experiment and compared with theoretical results. A total Raman enhancement factor of 1.4 × 10~4 is observed, with contribution mostly from the enhancement in pump laser intensity. Our results show that, with an efficient pumping scheme, dielectric microspheres are a viable alternative to metallic SERS substrates.
基金Supported by the following grants:the National Key R&D program of China(2018YFA0404201,2018YFA0404202,2018YFA0404203)the National Natural Science Foundation of China(12022502,11905227,U1931112,11635011,11761141001,Y811A35,11675187,U1831208,U1931111)in Thailand by RTA6280002 from Thailand Science Research and Innovation。
文摘The first Water Cherenkov detector of the LHAASO experiment(WCDA-1)has been operating since April 2019.The data for the first year have been analyzed to test its performance by observing the Crab Nebula as a standard candle.The WCDA-1 achieves a sensitivity of 65 mCU per year,with a statistical threshold of 5 cr.To accomplish this,a 97.7%cosmic-ray background rejection rate around 1 TeV and 99.8%around 6 TeV with an ap proximate photon acceptance of 50%is achieved after applying an algorithm to separate gamma-induced showers.The angular resolution is measured using the Crab Nebula as a point source to be approximately 0.45°at 1 TeV and better than 0.2°above 6 TeV,with a pointing accuracy better than 0.05°.These values all match the design specifications.The energy resolution is found to be 33%for gamma rays around 6 TeV.The spectral energy distribution of the Crab Nebula in the range from 500 GeV to 15.8 TeV is measured and found to be in agreement with the results from other TeV gamma ray observatories.
基金Supported in China by National Key R&D program of China(2018YFA0404201,2018YFA0404202,2018YFA0404203,2018YFA0404204)NSFC(U2031101,11475141,12147208)in Thailand by RTA6280002 from Thailand Science Research and Innovation。
文摘The Large High Altitude Air Shower Observatory(LHAASO)has three sub-arrays,KM2A,WCDA,and WFCTA.The flux variations of cosmic ray air showers were studied by analyzing the KM2A data during a thunderstorm on June 10,2021.The number of shower events that meet the trigger conditions increases significantly in atmospheric electric fields,with a maximum fractional increase of 20%.The variations in trigger rates(increases or decreases)were found to be strongly dependent on the primary zenith angle.The flux of secondary particles increased significantly,following a trend similar to that of shower events.To better understand the observed behavior,Monte Carlo simulations were performed with CORSIKA and G4KM2A(a code based on GEANT4).We found that the experimental data(in saturated negative fields)were in good agreement with the simulations,assuming the presence of a uniform electric field of-700 V/cm with a thickness of 1500 m in the atmosphere above the observation level.Due to the acceleration/deceleration by the atmospheric electric field,the number of secondary particles with energy above the detector threshold was modified,resulting in the changes in shower detection rate.
基金This work was supported by the National Natural Science Foundation of China(No.50271054)the State Educational Ministry for Scientific Research Foundation for the Returned Overseas Chinese Scholars.
文摘As-cast and corrosive microstructures of AZ91D alloy containing various Ce contents were observed by optical microscope (OM). The phase compositions of the alloys before and after the corrosion were analyzed by X-ray diffraction (XRD). Meanwhile, the corrosion resistance of the alloys was tested by weight loss and potentiodynamic polarization curve methods respectively. The results show that rod-like Al4Ce phase is formed in AZ91D alloy containing certain Ce content and as-cast microstructures are refined. AZ91D-0.7%Ce alloy has good grain refinement effect. The addition of Ce can reduce the corrosion rate and corrosion current density of AZ91D alloy and those of AZ91D-0.1%Ce alloy reach the minimum, which are 0.35mg/(cm2·d) and 2.761μA/cm2 with 75% and 86% reduction, respectively. The increasing volume fraction and reticular degree of β phase can improve the corrosion resistance of the alloys.
基金supported by the National Key R&D program of China under grants 2018YFA0404201This research work is also supported by the National Natural Science Foundation of China,with NSFC Grants No.11635011,No.11761141001,No.11905240,No.12105293,No.12105294,No.U2031103,No.U1831208,No.11503021,No.11205126,No.11947404,and No.11675187+2 种基金by IHEP innovation project No.E25451U2by the Science and Technology Department of Sichuan Province 2021YFSY0031by the Xiejialin Foundation of IHEP No.E2546IU2,by RTA6280002 from Thailand Science Research and Innovation in Thailand.
文摘Introduction One of main scientific goals of the Large High Altitude Air Shower Observatory(LHAASO)is to accurately measure the energy spectra of different cosmic ray compositions around the‘knee’region.The Wide Field-of-View(FoV)Cherenkov Telescope Array(WFCTA),which is one of the main detectors of LHAASO and has 18 telescopes,is built to achieve this goal.Multiple telescopes are put together and point to connected directions for a larger FoV.Method Telescopes are deployed spatially as close as possible,but due to their own size,the distance between two adjacent telescopes is about 10 m.Therefore,the Cherenkov lateral distribution and the parallax between the two telescopes should be considered in the event building process for images crossing over the boundaries of FoVs of the telescopes.An event building method for Cherenkov images measured by multiple telescopes of WFCTA is developed.The performance of the shower measurements using the combined images is evaluated by comparing with showers that are fully contained by a virtual telescope in simulation.Results and conclusion It is proved that the developed event building process can help to increase the FoV of WFCTA by 30%while maintaining the same reconstruction quality,compared to the separate telescope reconstruction method.
基金National Natural Science Foundation of China(11903005,11563004,11475190)。
文摘The LHAASO-WFCTA experiment,which aims to observe cosmic rays in the sub-EeV range using the fluorescence technique,uses a new generation of high-performance telescopes.To ensure that the experiment has ex-cellent detection capability associated with the measurement of the energy spectrum,the primary composition of cosmic rays,and so on,an accurate geometrical reconstruction of air-shower events is fundamental.This paper de-scribes the development and testing of geometrical reconstruction for stereo viewed events using the WFCTA(Wide Field of view Cherenkov/Fluorescence Telescope Array)detectors.Two approaches,which take full advantage ofthe WFCTA detectors.are investigated.One is the stereo-angular method,which uses the pointing of triggered SiPMs in the shower trajectory,and the other is the stereo-timing method,which uses the triggering time of the fired SiPMs.The results show that both methods have good geometrical resolution:the resolution of the stereo-timing method is slightly better than the stereo-angular method because the resolution of the latter is slightly limited by the shower track length.
基金Supported by National Natural Science Foundation of China(11761141001,11635011,11873005)The LHAASO project is supported by the National Key R&D Program of China(2018YFA0404200),the Chinese Academy of Sciences,the Key Laboratory of Particle Astrophysics,IHEP,CAS。
文摘The Water Cherenkov Detector Array(WCDA) is a major component of the Large High Altitude Air Shower Array Observatory(LHAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under construction. WCDA is aimed at the study of TeV γ-rays. In order to evaluate the prospects of searching for TeV γ-ray sources with WCDA, we present a projection of the one-year sensitivity of WCDA to TeV γ-ray sources from TeVCat using an all-sky approach. Out of 128 TeVCat sources observable by WCDA up to a zenith angle of 45°, we estimate that 42 would be detectable in one year of observations at a median energy of 1 TeV. Most of them are Galactic sources, and the extragalactic sources are Active Galactic Nuclei(AGN).
基金This research work is also supported by following grants.The National Key R&D program of China under the Grant 2018YFA0404201,2018YFA0404202 and 2018YFA0404203by the National Natural Science Foundation of China(NSFC Grants Nos.12022502,No.11905227,No.U1931112,No.11635011,No.11761141001,No.Y811A35,No.11675187,No.U1831208,No.11873005)+1 种基金by the Key R&D Program of SiChuan Province under the Grant 2019ZYZF0001in Thailand by RTA6280002 from Thailand Science Research and Innovation.
文摘Purpose The main scientific goal of LHAASO-WCDA is to survey gamma-ray sources with energy from 100 GeV to 30 TeV.To observe high-energy shower events,especially to measure the energy spectrum of cosmic rays from 100 TeV to 10 PeV,a dynamic range extension system(WCDA++)is designed to use a 1.5-inch PMT with a dynamic range of four orders of magnitude for each cell in WCDA-1.Method The dynamic range is extended by using these PMTs to measure the effective charge density in the core region of air shower events,which is an important parameter for identifying the composition of primary particles.Result and Conclusion The system has been running for more than one year.In this paper,the details of the design and performance of WCDA++are presented.
基金This work is supported by the National Key R&D Program of China under the Grant 2018YFA0404201the Natural Sciences Foundation of China under the Grants 12022502,11635011the Key R&D Program of SiChuan Province under the Grant 2019ZYZF0001.
文摘Purpose Observation of high energy and very high emission from Gamma Ray Bursts(GRBs)is crucial to study the gigantic explosion and the underline processes.With a large field-of-view and almost full duty cycle,the Water Cherenkov Detector Array(WCDA),a sub-array of the Large High Altitude Air Shower Observatory(LHAASO),is appropriate to monitor the very high energy emission from unpredictable transients such as GRBs.Method Nevertheless,the main issue for an extensive air shower array is the high energy threshold which limits the horizon of the detector.To address this issue a new trigger method is developed in this article to lower the energy threshold of WCDA for GRB observation.Result The proposed method significantly improves the detection efficiency of WCDA for gamma-rays around the GRB direction at 10-300 GeV.The sensitivity of the WCDA for GRB detection with the new trigger method is estimated.The achieved sensitivity of the quarter WCDA array above 10 GeV is comparable with that of Fermi-LAT.The data analysis process and corresponding fluence upper limit for GRB 190719C is presented as an example.
文摘Each year approximately 360,000 people in the United States suffer a peripheral nerve injury （PNI）, which is a leading source of lifelong disability （Kelsey et al., 1997; Noble et al., 1998）. The most frequent cause of PNIs is motor vehicle accidents, while gunshot wounds, stabbings, and birth trauma are also common factors. Patients suffering from disabilities as a result of their PNIs are also burdensome to the healthcare system, with aver- age hospital stays of 28 days each year （Kelsey et al., 1997; Noble et al., 1998）.
文摘Objective: To compare the short-time complications associated with time-opening suprapubic catheter (SPT) versus intermittent catheter (IC) in male patients with spinal cord injury (above level C5). Methods: A prospective review of records was carried out to identify SCI patients managed with SPT or IC between 2011 and 2016. The complications included renal function (Serum creatinine), urinary tract infection (UTI), bladder stones, urethral complications, scrotal, and gross hematuria. Patients were followed at week 4, 3 and 6 months;the urodynamic assessment was repeated at 6 months. Results: A total of 30 patients (11 SPT, 19 IC) were recruited in this trial. There is no significant difference between the two catheter groups for the entire out-come. Scrotal abscesses and urethral stricture were only seen in patients with IC. Conclusions: SPT has similar urological complication with IC for SCI patients (above level C5) except the incidence of scrotal abscesses and urethral stricture.
基金the support from the National Natural Science Foundation of China(No.51171033)the Fundamental Research Funds for the Central Universities(DUT15LAB05,DUT16LAB03)
文摘The microwave absorbents of Fe and C nanoparticles as magnetic loss and dielectric loss material respectively were composited with the polyvinyl alcohol （PVA） as binder by spray granulation method, The electromagnetic parameters of Fe and C composite particles were analyzed by vector network. The complex permittivity and magnetic permeability of Fe and C composite particles matched well with increasing C nanoparticle content, and then the microwave loss property was improved. A minimum reflection loss （RL） of -42.7 dB at 3.68 GHz for a composite with 4.6 mm in thickness can be obtained when the content ratio of the C nanoparticles, the modified Fe nanoparticles and the PVA is 21：49：30 （Sample 3）.
基金supported by the Canadian Research Chairs (CRC) programNational Sciences and Engineering Research Council (NSERC)+2 种基金State Key Lab of Advanced Welding & joining, HIT (No. AWPT-Z12-04)National Natural Science Foundation of China (Grant No. 51075232)Tsinghua University Initiative Scientific Research Program (Grant No. 2010THZ 02-1)
文摘Nano brazing of Pt-Ag nanoparticles with nano Ag filler metal is reported in this letter, which presents an effective way to join nanoobjects by femtosecond laser irradiation. The nano brazed interface between Pt-Ag and Ag showed good lattice matching along(111)_(Ag) //(111)_(Ag-Pt). Lattice mismatch can hardly be observed at the interface between the filler metal and Pt-Ag nanoparticle, which is important for the joint strength and normally does not occur during joining. The very low mismatch also suggested that melting and solidification occurred during nano brazing by femtosecond laser. The role of Brownian motion on the nano joining process is also discussed in this paper.
