目的 探讨心肌梗死溶栓危险指数(TRI)与急性心肌梗死(AMI)患者冠状动脉病变严重程度及介入治疗远期预后的关系.方法 采用前瞻性研究方法,连续纳入2013年1至12月在阜外医院接受经皮冠状动脉介入治疗(PCI)的AMI患者1 663例.冠状动脉病变...目的 探讨心肌梗死溶栓危险指数(TRI)与急性心肌梗死(AMI)患者冠状动脉病变严重程度及介入治疗远期预后的关系.方法 采用前瞻性研究方法,连续纳入2013年1至12月在阜外医院接受经皮冠状动脉介入治疗(PCI)的AMI患者1 663例.冠状动脉病变的严重程度通过SYNTAX评分评估.采用受试者工作特征(ROC)曲线分析TRI预测PCI术后2年全因死亡的最佳截断值.根据最佳截断值(23.05),将AMI患者分为高TRI组(TRI≥23.05,465例)和低TRI组(TRI<23.05,1 198例).采用多因素logistic回归分析TRI与SYNTAX评分≥33分的相关性.采用Cox比例风险回归模型分析PCI术后远期预后的影响因素.结果 高TRI组患者的SYNTAX评分高于低TRI组[13.00(7.00,20.50)分比10.25(7.00,17.00)分,P<0.001].多因素logistic回归分析显示,TRI与SYNTAX评分≥33分独立相关(OR=1.09,95% CI 1.03~1.16,P=0.004).术后2年,高TRI组全因死亡[4.1%(19/465)比0.3%(4/1 198), P<0.001]、心原性死亡[2.6%(12/465)比0.2%(2/1 198),P<0.001]和支架内血栓形成[1.7%(8/465)比0.5%(6/1 198),P=0.015]发生率均高于低TRI组.多因素Cox回归分析显示,TRI≥23.05是AMI患者PCI术后2年全因死亡(HR=5.22,95% CI 1.63~16.72,P=0.005)、心原性死亡(HR=8.48,95% CI 1.75~41.07,P=0.008)和支架内血栓形成(HR=3.87,95% CI 1.32~11.41,P=0.014)的独立危险因素,不是术后2年严重不良心脑血管事件的独立危险因素(HR=0.96,95%CI 0.69~1.36,P=0.834).TRI≥23.05预测AMI患者PCI术后2年全因死亡的ROC曲线下面积为0.803(95% CI 0.711~0.894,P<0.001).结论TRI与SYNTAX评分≥33分独立相关;高TRI是AMI患者PCI术后2年全因死亡、心原性死亡和支架内血栓形成的独立危险因素.展开更多
Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of ...Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients.展开更多
Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but i...Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but it is challenging to extract because most helium atoms are reserved in defects of crystals or as solid solutions.Here,we find large amounts of helium bubbles in the glassy surface layer of ilmenite particles that were brought back by the Chang’E-5 mission.The special disordered atomic packing structure of glasses should be the critical factor for capturing the noble helium gas.The reserves in bubbles do not require heating to high temperatures to be extracted.Mechanical methods at ambient temperatures can easily break the bubbles.Our results provide insights into the mechanism of helium gathering on the moon and offer guidance on future in situ extraction.展开更多
There is a lack of understanding of both the conversion of an unstable glass into a metastable supercooled liquid(MSL) upon heating and the metastability of MSLs. In this study, we investigated the time-and temperatur...There is a lack of understanding of both the conversion of an unstable glass into a metastable supercooled liquid(MSL) upon heating and the metastability of MSLs. In this study, we investigated the time-and temperature-dependent metastability of an MSL using an advanced nano-calorimetric technique. The chosen Au-based metallic glass(Au MG) allowed adequate probing of its MSL in a temperature range between 10 and 70 K above the standard glass transition temperature. We found that the survival time of the MSL state is a quadratic function of temperature. Beyond this duration threshold, the sample undergoes fast crystallization even if it is below the crystallization temperature that is measured using differential scanning calorimetry.Employing transmission electron microscopy, we observed the formation of clusters with a partially ordered lattice structure during relaxation in the Au MG sample fabricated using a nano-calorimeter. The atomic ordering within the clusters was enhanced by increasing time and temperature in the MSL region. Once the as-produced glass entered the MSL stage upon heating followed by a quenching stage at a given rate, the mechanical properties of the quenched glass remained the same regardless of its holding temperature and duration within the MSL region. This work provides insights into the glass-MSL-crystal transformation and offers guidance for designing standard metallic glasses for property characterizations.展开更多
文摘目的 探讨心肌梗死溶栓危险指数(TRI)与急性心肌梗死(AMI)患者冠状动脉病变严重程度及介入治疗远期预后的关系.方法 采用前瞻性研究方法,连续纳入2013年1至12月在阜外医院接受经皮冠状动脉介入治疗(PCI)的AMI患者1 663例.冠状动脉病变的严重程度通过SYNTAX评分评估.采用受试者工作特征(ROC)曲线分析TRI预测PCI术后2年全因死亡的最佳截断值.根据最佳截断值(23.05),将AMI患者分为高TRI组(TRI≥23.05,465例)和低TRI组(TRI<23.05,1 198例).采用多因素logistic回归分析TRI与SYNTAX评分≥33分的相关性.采用Cox比例风险回归模型分析PCI术后远期预后的影响因素.结果 高TRI组患者的SYNTAX评分高于低TRI组[13.00(7.00,20.50)分比10.25(7.00,17.00)分,P<0.001].多因素logistic回归分析显示,TRI与SYNTAX评分≥33分独立相关(OR=1.09,95% CI 1.03~1.16,P=0.004).术后2年,高TRI组全因死亡[4.1%(19/465)比0.3%(4/1 198), P<0.001]、心原性死亡[2.6%(12/465)比0.2%(2/1 198),P<0.001]和支架内血栓形成[1.7%(8/465)比0.5%(6/1 198),P=0.015]发生率均高于低TRI组.多因素Cox回归分析显示,TRI≥23.05是AMI患者PCI术后2年全因死亡(HR=5.22,95% CI 1.63~16.72,P=0.005)、心原性死亡(HR=8.48,95% CI 1.75~41.07,P=0.008)和支架内血栓形成(HR=3.87,95% CI 1.32~11.41,P=0.014)的独立危险因素,不是术后2年严重不良心脑血管事件的独立危险因素(HR=0.96,95%CI 0.69~1.36,P=0.834).TRI≥23.05预测AMI患者PCI术后2年全因死亡的ROC曲线下面积为0.803(95% CI 0.711~0.894,P<0.001).结论TRI与SYNTAX评分≥33分独立相关;高TRI是AMI患者PCI术后2年全因死亡、心原性死亡和支架内血栓形成的独立危险因素.
基金supported by the National Natural Science Foundation of China[grant number 81400626]the National Natural Science Foundation for innovation group[grant number 81721002].
文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients.
基金financial support from National Natural Science Foundation of China(NSFC 51922102,92163108,61888102,11790291)Youth Innovation Promotion Association CAS(2019296)+1 种基金Zhejiang Provincial Natural Science Foundation of China(LZ22A030001,LR22E010004)Ningbo 2025 Science and Technology Innovation Project(2022Z033)are acknowledged.
文摘Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but it is challenging to extract because most helium atoms are reserved in defects of crystals or as solid solutions.Here,we find large amounts of helium bubbles in the glassy surface layer of ilmenite particles that were brought back by the Chang’E-5 mission.The special disordered atomic packing structure of glasses should be the critical factor for capturing the noble helium gas.The reserves in bubbles do not require heating to high temperatures to be extracted.Mechanical methods at ambient temperatures can easily break the bubbles.Our results provide insights into the mechanism of helium gathering on the moon and offer guidance on future in situ extraction.
基金supported by the Songshan Lake Materials Laboratory (Grant No. 2021SLABFN05)the National Natural Science Foundation of China (Grant Nos. 51971120, 51901139)+2 种基金the Taishan Scholars Program of Shandong Province (Grant No. tsqn201909010)the Key Basic and Applied Research Program of Guangdong Province(Grant No. 2019B030302010)the Sao Paulo Research Foundation–FAPESP (Grant No.#2013/07793-6)。
文摘There is a lack of understanding of both the conversion of an unstable glass into a metastable supercooled liquid(MSL) upon heating and the metastability of MSLs. In this study, we investigated the time-and temperature-dependent metastability of an MSL using an advanced nano-calorimetric technique. The chosen Au-based metallic glass(Au MG) allowed adequate probing of its MSL in a temperature range between 10 and 70 K above the standard glass transition temperature. We found that the survival time of the MSL state is a quadratic function of temperature. Beyond this duration threshold, the sample undergoes fast crystallization even if it is below the crystallization temperature that is measured using differential scanning calorimetry.Employing transmission electron microscopy, we observed the formation of clusters with a partially ordered lattice structure during relaxation in the Au MG sample fabricated using a nano-calorimeter. The atomic ordering within the clusters was enhanced by increasing time and temperature in the MSL region. Once the as-produced glass entered the MSL stage upon heating followed by a quenching stage at a given rate, the mechanical properties of the quenched glass remained the same regardless of its holding temperature and duration within the MSL region. This work provides insights into the glass-MSL-crystal transformation and offers guidance for designing standard metallic glasses for property characterizations.
