目的:分析曲安奈德(TA)联合黄斑区格栅样光凝治疗视网膜分支静脉阻塞(BRVO)继发黄斑水肿(ME)的疗效及安全性。方法:将2016-01/2020-01在本院诊治的BRVO继发ME患者147例147眼随机分为观察组(73眼)和对照组(74眼),观察组接受玻璃体腔注射T...目的:分析曲安奈德(TA)联合黄斑区格栅样光凝治疗视网膜分支静脉阻塞(BRVO)继发黄斑水肿(ME)的疗效及安全性。方法:将2016-01/2020-01在本院诊治的BRVO继发ME患者147例147眼随机分为观察组(73眼)和对照组(74眼),观察组接受玻璃体腔注射TA联合黄斑区格栅样光凝治疗,对照组接受玻璃体腔注射康柏西普联合黄斑区格栅样光凝治疗。随访6mo,比较两组的疗效及安全性指标。结果:治疗后两组最佳矫正视力(BCVA,LogMAR)均较治疗前改善;治疗后1mo时观察组BCVA优于对照组(0.22±0.15 vs 0.27±0.13,P<0.05);治疗后6mo时观察组中年龄<50岁患者BCVA显著优于对照组中年龄<50岁患者(0.09±0.04 vs 0.14±0.06,P<0.05),两组中浆液性视网膜脱离(SRD)型患者BCVA均显著优于囊样水肿(CME)型与混合型患者,CME型患者BCVA均显著优于混合型患者(P<0.05),但两组之间各ME分型亚组患者BCVA均无差异(P>0.05)。治疗后两组黄斑中心凹视网膜厚度(CMT)均较治疗前明显下降;治疗后3mo时观察组CMT高于对照组(309.76±84.24μm vs 258.75±88.76μm,P<0.01)。治疗后1wk,1、3、6mo时观察组眼压均高于对照组(P<0.01)。治疗后6mo时,两组浅层毛细血管(SCP)血流密度较治疗前明显上升(P<0.05),深层毛细血管(DCP)血流密度、中心凹无血管区(FAZ)面积则未见明显改变(P>0.05)。观察组眼压升高发生率高于对照组(28.8%vs 14.9%),玻璃体腔注射次数低于对照组(1.21±0.74次vs 3.62±2.08次)。结论:TA联合黄斑区格栅样光凝治疗BRVO继发ME可短期内将视力维持在一定水平,在视力、CMT上的获益与康柏西普联合黄斑区格栅样光凝治疗相当,但存在眼压升高现象,需加强眼压监测。展开更多
The valve gasket for aero-engine is prone to creep under extreme conditions such as high temperature and high pressure.The creep failure of the gasket leads to valve leakage,which seriously threatens the safe and reli...The valve gasket for aero-engine is prone to creep under extreme conditions such as high temperature and high pressure.The creep failure of the gasket leads to valve leakage,which seriously threatens the safe and reliable operation of aero-engine.Aiming at the creep failure of FEP gasket in use,a timehardening creep model of valve gasket seal is established.The effects of time,operating pressure,material and structural parameters on the creep and sealing properties of FEP gaskets are analyzed.The results show that the compression rebound rate of gaskets decreases with the increase of time,and small compression rebound rate will decrease the sealing performance.The creep behavior of FEP gasket increases with the increase of operating pressure.Reducing the fillet radius can reduce the probability of shear failure,but also reduce the contact stress.Increasing the height of the boss can reduce the deformation behavior of the gasket,but reduce the contact stress on the sealing surface.When the gasket bevel angle is 85°,the creep property and contact stress of the gasket are higher than those of other sizes.But large bevel angle leads to the gasket unsticking.Replacing the FEP material with the polyimide material can improve the creep resistance of gaskets and the contact stress of sealing surface.Considering the service life and sealing effect of gasket,the material is replaced with polyimide plastic,the fillet radius is 0.20mm,the bevel angle is 85°and the boss height is 0.2mm.展开更多
国际新媒体联盟(New Media Consortium,简称NMC)发布的《地平线报告(高等教育版)》已成为高等教育未来发展与革新的指南,影响着新兴技术在高等教育中的应用与发展。《2017地平线报告(高等教育版)》的发布,再一次吸引了国内外学者的眼球...国际新媒体联盟(New Media Consortium,简称NMC)发布的《地平线报告(高等教育版)》已成为高等教育未来发展与革新的指南,影响着新兴技术在高等教育中的应用与发展。《2017地平线报告(高等教育版)》的发布,再一次吸引了国内外学者的眼球。该地平线报告采用德尔菲法,预测高等教育未来5年所采用的六项关键技术、六个发展趋势、六项挑战。六项关键技术:自适应学习技术、移动学习、物联网、下一代学习管理系统、人工智能、自然用户界面。六个发展趋势:混合学习设计、协作学习方法、日益注重学习测量、重新设计学习空间、推动创新文化、深度学习方法。六项挑战:提升数字素养、整合正式学习与非正式学习、成就差异、数字公平、管理知识老化、重塑教育者角色。通过解读报告,分析了新兴技术影响高等教育的教学、学习和创新等问题,并对未来高等教育的发展做深入的讨论。展开更多
文摘目的:分析曲安奈德(TA)联合黄斑区格栅样光凝治疗视网膜分支静脉阻塞(BRVO)继发黄斑水肿(ME)的疗效及安全性。方法:将2016-01/2020-01在本院诊治的BRVO继发ME患者147例147眼随机分为观察组(73眼)和对照组(74眼),观察组接受玻璃体腔注射TA联合黄斑区格栅样光凝治疗,对照组接受玻璃体腔注射康柏西普联合黄斑区格栅样光凝治疗。随访6mo,比较两组的疗效及安全性指标。结果:治疗后两组最佳矫正视力(BCVA,LogMAR)均较治疗前改善;治疗后1mo时观察组BCVA优于对照组(0.22±0.15 vs 0.27±0.13,P<0.05);治疗后6mo时观察组中年龄<50岁患者BCVA显著优于对照组中年龄<50岁患者(0.09±0.04 vs 0.14±0.06,P<0.05),两组中浆液性视网膜脱离(SRD)型患者BCVA均显著优于囊样水肿(CME)型与混合型患者,CME型患者BCVA均显著优于混合型患者(P<0.05),但两组之间各ME分型亚组患者BCVA均无差异(P>0.05)。治疗后两组黄斑中心凹视网膜厚度(CMT)均较治疗前明显下降;治疗后3mo时观察组CMT高于对照组(309.76±84.24μm vs 258.75±88.76μm,P<0.01)。治疗后1wk,1、3、6mo时观察组眼压均高于对照组(P<0.01)。治疗后6mo时,两组浅层毛细血管(SCP)血流密度较治疗前明显上升(P<0.05),深层毛细血管(DCP)血流密度、中心凹无血管区(FAZ)面积则未见明显改变(P>0.05)。观察组眼压升高发生率高于对照组(28.8%vs 14.9%),玻璃体腔注射次数低于对照组(1.21±0.74次vs 3.62±2.08次)。结论:TA联合黄斑区格栅样光凝治疗BRVO继发ME可短期内将视力维持在一定水平,在视力、CMT上的获益与康柏西普联合黄斑区格栅样光凝治疗相当,但存在眼压升高现象,需加强眼压监测。
基金National Key Research and Development Program of China(2018YFB200800)。
文摘The valve gasket for aero-engine is prone to creep under extreme conditions such as high temperature and high pressure.The creep failure of the gasket leads to valve leakage,which seriously threatens the safe and reliable operation of aero-engine.Aiming at the creep failure of FEP gasket in use,a timehardening creep model of valve gasket seal is established.The effects of time,operating pressure,material and structural parameters on the creep and sealing properties of FEP gaskets are analyzed.The results show that the compression rebound rate of gaskets decreases with the increase of time,and small compression rebound rate will decrease the sealing performance.The creep behavior of FEP gasket increases with the increase of operating pressure.Reducing the fillet radius can reduce the probability of shear failure,but also reduce the contact stress.Increasing the height of the boss can reduce the deformation behavior of the gasket,but reduce the contact stress on the sealing surface.When the gasket bevel angle is 85°,the creep property and contact stress of the gasket are higher than those of other sizes.But large bevel angle leads to the gasket unsticking.Replacing the FEP material with the polyimide material can improve the creep resistance of gaskets and the contact stress of sealing surface.Considering the service life and sealing effect of gasket,the material is replaced with polyimide plastic,the fillet radius is 0.20mm,the bevel angle is 85°and the boss height is 0.2mm.
文摘国际新媒体联盟(New Media Consortium,简称NMC)发布的《地平线报告(高等教育版)》已成为高等教育未来发展与革新的指南,影响着新兴技术在高等教育中的应用与发展。《2017地平线报告(高等教育版)》的发布,再一次吸引了国内外学者的眼球。该地平线报告采用德尔菲法,预测高等教育未来5年所采用的六项关键技术、六个发展趋势、六项挑战。六项关键技术:自适应学习技术、移动学习、物联网、下一代学习管理系统、人工智能、自然用户界面。六个发展趋势:混合学习设计、协作学习方法、日益注重学习测量、重新设计学习空间、推动创新文化、深度学习方法。六项挑战:提升数字素养、整合正式学习与非正式学习、成就差异、数字公平、管理知识老化、重塑教育者角色。通过解读报告,分析了新兴技术影响高等教育的教学、学习和创新等问题,并对未来高等教育的发展做深入的讨论。
