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INTRAGRANULAR FERRITE FORMED IN ASSOCIATION WITH INCLUSIONS IN A VANADIUM MICROALLOYED STEEL 被引量:3
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作者 k.M.wu M.Enomoto 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2004年第6期785-789,共5页
Intragranular ferrite was formed at inclusions in a vanadium microalloyed steel with excess amount of sulfur. The chemical composition of inclusions in the steel was analyzed by SEM-EDS. The inclusions were mainly com... Intragranular ferrite was formed at inclusions in a vanadium microalloyed steel with excess amount of sulfur. The chemical composition of inclusions in the steel was analyzed by SEM-EDS. The inclusions were mainly composed of MnS and aluminum oxides. The precipitation of MnS at aluminum oxides might result in Mn depletion, which, in turn, pro- motes the formation of intragranular ferrite. Optical and SEM observations and three- dimensional (3D) reconstruction demonstrated that intragranular ferrite was formed at inclusions. The morphology of intragranular ferrite changed with undercooling. At higher temperatures intragranular ferrite was nearly equiaxed whereas it was plate-like or lath-like at lower temperatures. 展开更多
关键词 STEELS intragranular ferrite NUCLEATION three-dimensional reconstruction
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THREE-DIMENSIONAL VISUALIZATION OF DEGENERATE FERRITE FORMED BELOW TTT-DIAGRAM BAY IN AN Fe-C-Mo ALLOY 被引量:1
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作者 k.M.wu M.Enomoto 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2003年第3期169-174,共6页
The evolution of degenerate ferrite in an Fe-0.28wt%C-3.0wt%Mo alloy isothermally reacted for 10ks at 20℃ below TTT diagram bay temperature have been revealed utilizing serial sectioning in conjunction with computer ... The evolution of degenerate ferrite in an Fe-0.28wt%C-3.0wt%Mo alloy isothermally reacted for 10ks at 20℃ below TTT diagram bay temperature have been revealed utilizing serial sectioning in conjunction with computer reconstruction and visualization. The degenerate ferrite is initially formed at prior austenite boundary and then grows toward grain interior rather than along the grain boundary. The degenerate morphology of ferrite may be attributed to repeated nucleation, growth and coalescence of adjacent ferrite crystals. The shape of individual ferrite crystals appears to be rod-like. 展开更多
关键词 steel phase transformation microstructure FERRITE
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China’s soft power and US public opinion
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作者 Yao-Yuan Yeh Charles k.S.wu Wei-hao Huang 《Economic and Political Studies》 2021年第4期447-460,共14页
In recent years,China has been using its soft power(most notably,the establishment of Confucius Institutes)to influence public opinion in foreign countries.However,the literature on soft power has yet to provide a def... In recent years,China has been using its soft power(most notably,the establishment of Confucius Institutes)to influence public opinion in foreign countries.However,the literature on soft power has yet to provide a definitive answer about whether that has led to a positive image of China in the foreign audience.Additionally,it is not clear if a positive image would influence public attitudes concerning foreign policies in those countries,such as policies related to trade and military conflicts.Based on an online survey experiment in June 2018,this research shows that soft power information(about positive contributions of Confucius Institutes to the American society)does make the US public feel warmer towards China and become more willing to support trade negotiations.However,the warm feeling does not alter public attitudes towards a potential military conflict with China over disputed islands in the South China Sea.Our study provides both empirical support and advice to policymakers interested in the influence of China’s soft power on US public opinion. 展开更多
关键词 Soft power hard power American public opinion China
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Experimental methods for determination of mechanical behaviors of materials at high temperatures via the split Hopkinson bars 被引量:3
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作者 Q.B.Dou k.R.wu +5 位作者 T.Suo C.Zhang X.Guo Y.Z.Guo W.G.Guo Y.L.Li 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2020年第6期1275-1293,I0003,共20页
Full understanding of the thermomechanical behaviors of materials at high strain rates and high temperatures are of great importance from not only scientific meaning but also practical value in engineering structure d... Full understanding of the thermomechanical behaviors of materials at high strain rates and high temperatures are of great importance from not only scientific meaning but also practical value in engineering structure design and safety assessment.Great efforts have been made for abilities of operation the split Hopkinson bars,the most popular technique for experimental determination of mechanical behaviors of materials over the strain rates from 10^2 to 10^4 s^−1 over the past 70 years,at high temperatures since 1960s.A review of experiment work is presented in this paper to give an overview of the development of experimental techniques at high temperatures based on Hopkinson bar systems.The principles of the split Hopkinson bar requires the loading bars avoiding temperature gradient or keeping relatively low temperature when performing high temperature testing.Techniques such as performing temperature gradient corrections,rapid heating or using special designed automatically assembled systems were proposed by researchers to enable the operation of the split Hopkinson bars at temperature as high as possible.Moreover,to the application of high speed photographic technique for capturing the dynamic deformation process of the specimen in high temperature Hopkinson bar testing,some key issues of eliminating the strong thermal radiation induced lights oversaturation and de-blurring of images due to insufficient exposure at high temperature and high strain rate condition,as well as fabrication of high contrast speckle pattern for high temperature digital image correlation measurement were also proposed.The technique can now enable the split Hopkinson bar testing to be performed at high temperature up to 1873 K under the loading conditions of compression or tension with the in situ observation and full field measurement of deformation as well.The paper concludes with summaries of the most important achievements and highlighting of the prospects,trends and remaining challenges for future research. 展开更多
关键词 Mechanical behaviors Split Hopkinson bar High strain rate High temperature
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Effects of Ta Addition on Microstructure and Transformation Behavior of Ni-Ti Alloys
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作者 k.H.wu and JL.Ma Department of Mechanical Engineering, Florida International University, Miami, FL 33174, U.S.A. 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2001年第1期5-6,共2页
The effect of adding Ta on the changes of microstructure and Ms temperature of a dualphase shape memory alloy with compositions of (Ni51 Ti49)1 -x.Tax. and Ni50-Ti50 -g.Ta.g were systematically studied. An optical mi... The effect of adding Ta on the changes of microstructure and Ms temperature of a dualphase shape memory alloy with compositions of (Ni51 Ti49)1 -x.Tax. and Ni50-Ti50 -g.Ta.g were systematically studied. An optical microscope, SEM, X-ray diffraction and DSC were utilized in this work. The evolution of the microstructure as a function of Ta content was characterized. The variation of the Ni/Ti ratio in the NiTi phase plays an important role in the change of the Ms temperatures due to the addition of Ta. A pseudobinary NiTi-Ta phase diagram was proposed based on these results. 展开更多
关键词 Ti TA Effects of Ta Addition on Microstructure and Transformation Behavior of Ni-Ti Alloys
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Magnesium matrix composite reinforced by nanoparticles-A review 被引量:26
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作者 k.B.Nie X.J.Wang +2 位作者 k.k.Deng X.S.Hu k.wu 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2021年第1期57-77,共21页
Significant progress has been made in magnesium-based composites during recent decades,especially for the appearance of magnesium matrix composite reinforced by nanoparticles.The nanoparticles added not only exhibit a... Significant progress has been made in magnesium-based composites during recent decades,especially for the appearance of magnesium matrix composite reinforced by nanoparticles.The nanoparticles added not only exhibit a good strengthening effect,but also maintain the initial toughness of the matrix,effectively balancing the contradiction between the strength and plasticity in the traditional magnesium matrix composites.The magnesium matrix nanocomposites with excellent mechanical properties have pushed the development of magnesium matrix composites to a new stage.However,it is very difficult to disperse the nanoparticles in metal melt especially in magnesium melt which is different from other metal melts and dangerous during the cast processing.This means that the preparation of magnesium matrix nanocomposite is extremely challenging.Further,the magnesium matrix nanocomposites possess a distinctive characteristic in deformation behavior,strengthening and toughening mechanism due to their special size effect of nanoparticles.Accordingly,this review will focus on the new preparation technologies,deformation behavior,mechanical properties and strengthening and toughening mechanisms.The potential applications,development trends and future research ideas of magnesium matrix nanocomposite are also prospected.©2020 Published by Elsevier B.V.on behalf of Chongqing University. 展开更多
关键词 Magnesium matrix nanocomposite MICROSTRUCTURE Mechanical properties Strengthening mechanism
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Processing, Microstructure and Mechanical Properties of Ti6Al4V Particles-Reinforced Mg Matrix Composites 被引量:9
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作者 X.M.Wang X.J.Wang +2 位作者 X.S.Hu k.wu M.Y.Zheng 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2016年第10期940-950,共11页
Novel Ti6Al4V particles-reinforced AZ91 Mg matrix composites were successfully fabricated by stir casting method. The stirring time in semisolid condition directly affected the particle distribution and the quality of... Novel Ti6Al4V particles-reinforced AZ91 Mg matrix composites were successfully fabricated by stir casting method. The stirring time in semisolid condition directly affected the particle distribution and the quality of the ingots. Furthermore, the optimal speed of the heating and the liquid stirring could overcome particle settlement caused by the density difference between the matrix and the particles. Ti6Al4V particles distributed uniformly in the composites with different particle contents. The average grain size decreased with the increase in the particle contents. The Ti6A14V particles bonded pretty well with the alloy matrix. In addition, there were some interfacial reactions in the composites. There were rod-like A13Ti phases at the interface. The precipitates extended from the particle surface to the matrix, and they might improve the interfacial bonding strength. The ultimate tensile strength, yield strength and elastic modulus were enhanced as the particle contents increased, and the elongation was much better than that of the same matrix material reinforced with SiC particles. Thus, the novel composites exhibit better comprehensive mechanical properties. 展开更多
关键词 Magnesium matrix composites Ti6Al4V particles Stir casting Microstructure Mechanicalproperties
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SUPERPLASTICITY IN SiC_w/ZK60 COMPOSITE 被引量:4
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作者 F.Yan k.wu M.Zhao 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2003年第3期217-220,共4页
The superplastic deformation behavior of SiCw/ZK60 composite was investigated at temperatures ranging from 573K to 723K and at initial strain rates ranging from 8.3x10-4s-1 to 8.3x10-2s-1. A maximum elongation of 200%... The superplastic deformation behavior of SiCw/ZK60 composite was investigated at temperatures ranging from 573K to 723K and at initial strain rates ranging from 8.3x10-4s-1 to 8.3x10-2s-1. A maximum elongation of 200% with a m-value of 0.35 was obtained at 613K and a initial strain rate of 1.67x 10-2s-1. The apparent activation energy (98kJ/mol) approximates that for grain boundary diffusion (92kJ/mol) in magnesium. It is proposed that the dominant mechanism of superplastic deformation in the present composite is grain boundary sliding accommodated by diffusional transport, besides, interfacial sliding plays an important role in the superplastic deformation. 展开更多
关键词 magnesium matrix composite SUPERPLASTICITY apparent activation energy
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A Novel Melt Processing for Mg Matrix Composites Reinforced by Multiwalled Carbon Nanotubes 被引量:4
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作者 H.L.Shi X.J.Wang +4 位作者 C.L.Zhang C.D.Li C.Ding k.wu X.S.Hu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2016年第12期1303-1308,共6页
Carbon nanotubes(CNTs) reinforced Mg matrix composites were fabricated by a novel melt processing.The novel processing consisted of two courses:CNTs pre-dispersion and ultrasonic melt processing.Mechanical ball-mil... Carbon nanotubes(CNTs) reinforced Mg matrix composites were fabricated by a novel melt processing.The novel processing consisted of two courses:CNTs pre-dispersion and ultrasonic melt processing.Mechanical ball-milling was employed to pre-disperse CNTs on Zinc(Zn) flakes.Serious CNT entanglements were well dispersed to single CNT or tiny clusters on Zn flakes.The ultrasonic melt processing further dispersed CNTs in the Mg melt,especially tiny CNT clusters.Thus,a uniform dispersion of CNTs was achieved in the as-cast composites.Hot extrusion further improved the distribution of CNTs.CNTs increased both the strength and elongation of the matrix alloy.Notably,the elongation of the matrix alloy was enhanced by 40%.Grain refinement and the pulling-out of CNTs resulted in the evident improvement of ductility for the composites. 展开更多
关键词 Pre-dispersion Carbon nanotubes Magnesium matrix composites Ultrasonic
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An insight into Mg alloying effects on Cu thin films:microstructural evolution and mechanical behavior 被引量:3
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作者 G.Y.Li L.F.Cao +5 位作者 J.Y.Zhang X.G.Li Y.Q.Wang k.wu G.Liu J.Sun 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2020年第22期101-112,共12页
How to design ultra-strong,light-weight Cu alloys is a long-term pursuit in materials community,which is technically superior and cost-effective for their promising energy-saving applications.In this work,we prepared ... How to design ultra-strong,light-weight Cu alloys is a long-term pursuit in materials community,which is technically superior and cost-effective for their promising energy-saving applications.In this work,we prepared Cu-Mg alloyed thin films to study light element Mg alloying effects on the microstructure,hardness and strain rate sensitivity(SRS) of nanocrystalline Cu thin films.In the studied Mg concentrationrange spanning from 0 at.% to 16.8 at.%,both the grain size and the twin spacing decrease monotonously with increasing Mg composition while Cu-2.8 at.% Mg sample has the highest twin fraction of ~75%.A combined strengthening model was employed to quantify the Mg concentration-dependent hardness of nanotwinned(NT) Cu-Mg thin films,in which the grain/twin boundary facilitates strengthening while the solute Mg atoms induce softening.Both the constant rate of loading tests and the nanoindentation creep tests uncover that compared with pure Cu samples,the NT Cu-Mg thin films manifest much lower SRS,particularly in the creep tests,owing to the activation of dynamic strain aging effects. 展开更多
关键词 Cu-Mg thin films Microstructure evolution Creep tests Hardness Strain rate sensitivity
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Microstructure and room temperature tensile properties of 1μm-SiCp/AZ31B magnesium matrix composite 被引量:1
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作者 M.J.Shen X.J.Wang +3 位作者 M.F.Zhang B.H.Zhang M.Y.Zheng k.wu 《Journal of Magnesium and Alloys》 SCIE EI CAS 2015年第2期155-161,共7页
In the present study,AZ31B magnesium matrix composites reinforced with two volume fractions(3 and 5 vol.%)of micron-SiC particles(1μm)were fabricated by semisolid stirring assisted ultrasonic vibration method.The as-... In the present study,AZ31B magnesium matrix composites reinforced with two volume fractions(3 and 5 vol.%)of micron-SiC particles(1μm)were fabricated by semisolid stirring assisted ultrasonic vibration method.The as-cast ingots were extruded at 350℃ with the extrusion ratio of 15:1 at a constant ram speed of 15 mm/s.The microstructure of the composites was investigated by optical microscopy,scanning electron microscope and transmission electron microscope.Microstructure characterization of the composites showed relative uniform reinforcement distribution and significant grain refinement.The presence of 1μm-SiC particles assisted in improving the elastic modulus and tensile strength.The ultimate tensile strength and yield strength of the 5 vol.%SiCp/AZ31B composites were simultaneously improved. 展开更多
关键词 Magnesium matrix composite MICROSTRUCTURE Mechanical properties
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Unusual He-ion irradiation strengthening and inverse layer thickness-dependent strain rate sensitivity in transformable high-entropy alloy/metal nanolaminates:A comparison of Fe_(50)Mn_(30)Co_(10)Cr_(10)/Cu vs Fe_(50)Mn_(30)Co_(10)Ni_(10)/Cu 被引量:1
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作者 Y.F.Zhao H.H.Chen +5 位作者 D.D.Zhang J.Y.Zhang Y.Q.Wang k.wu G.Liu J.Sun 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2022年第21期199-213,共15页
In this work,we prepare transformable HEA/Cu nanolaminates(NLs)with equal individual layer thick-ness(h)by the magnetron sputtering technique,i.e.,Fe_(50)Mn_(30)Co_(10)Cr_(10)/Cu and Fe_(50)Mn_(30)Co_(10)Ni_(10)/Cu,an... In this work,we prepare transformable HEA/Cu nanolaminates(NLs)with equal individual layer thick-ness(h)by the magnetron sputtering technique,i.e.,Fe_(50)Mn_(30)Co_(10)Cr_(10)/Cu and Fe_(50)Mn_(30)Co_(10)Ni_(10)/Cu,and comparatively study He-ion irradiation effects on their microstructure and mechanical properties.It ap-pears that the as-deposited HEA/Cu NLs manifest two size h-dependent hardness regimes(i.e.,increased hardness at small h and hardness plateau at large h),while the He-implanted ones exhibit monotonically increased hardness.Contrary to the fashion that smaller h renders less irradiation hardening in bimetal NLs,the Fe_(50)Mn_(30)Co_(10)Cr_(10)/Cu NLs manifest the trend that smaller h leads to greater irradiation hard-ening.By contrast,the Fe_(50)Mn_(30)Co_(10)Ni_(10)/Cu NLs exhibit the maximum irradiation hardening at a critical h=50 nm.Below this critical size,smaller h results in lower radiation hardening(similar to bimetal NLs),while above this size,smaller h results in greater radiation hardening(similar to Fe_(50)Mn_(30)Co_(10)Cr_(10)/Cu NLs).Moreover,these transformable HEA/Cu NLs display inverse h-dependent strain rate sensitivity(SRS m)before and after He-ion irradiation.Nevertheless,compared with as-deposited samples,the irradi-ated Fe_(50)Mn_(30)Co_(10)Cr_(10)/Cu NLs display reduced SRS,while the irradiated Fe_(50)Mn_(30)Co_(10)Ni_(10)/Cu NLs dis-play enhanced SRS.Such unusual size-dependent irradiation strengthening and inverse h effect on SRS in irradiated samples were rationalized by considering the blocking effects of He bubbles on dislocation nucleation and motion,i.e.,dislocations shearing or bypassing He bubbles. 展开更多
关键词 High entropy alloy/metal nanolaminates Interfaces Irradiation hardening Strain rate sensitivity Size effects
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耳部瘢痕疙瘩的治疗进展 被引量:14
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作者 刘科 武晓莉 王珮华 《中华耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2016年第12期945-948,共4页
耳部瘢痕疙瘩是瘢痕疙瘩的一种,分布于耳垂和耳轮,常继发于穿耳孔、烧烫伤等原因,因其高复发率而成为耳鼻喉科的一大难题.临床上采用手术切除、药物注射、物理治疗等多种措施综合、系统地治疗,可取得良好的疗效.本篇综述对各种治疗方法... 耳部瘢痕疙瘩是瘢痕疙瘩的一种,分布于耳垂和耳轮,常继发于穿耳孔、烧烫伤等原因,因其高复发率而成为耳鼻喉科的一大难题.临床上采用手术切除、药物注射、物理治疗等多种措施综合、系统地治疗,可取得良好的疗效.本篇综述对各种治疗方法进行回顾. 展开更多
关键词 瘢痕疙瘩 治疗应用
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甘蔗QTL定位与标记辅助选择的初步研究 被引量:5
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作者 邓海华 k.k.wu Tim Wenslaff 《甘蔗糖业》 2001年第1期1-12,共12页
利用La Purple(S. officinarum L.) X Mol 5829(S.robustum Brands and Jeswiet exGrassel)杂交一代群体获得的RFLP和RAPD分子标记信息,用区间定位法... 利用La Purple(S. officinarum L.) X Mol 5829(S.robustum Brands and Jeswiet exGrassel)杂交一代群体获得的RFLP和RAPD分子标记信息,用区间定位法( interval mapping)和单标记分析(point analysis)法测定控制转光度(%)、小区蔗茎产量、纤维分(%)和抽穗茎率的QTL。选用与转光度和茎产量显著关联(F测验P<0.01或区间定位中LOD>2)的分子标记进一步对标记辅助选择的效果进行分析。对任一性状而言,与之显著关联的标记都含有正效应的和负效应的两类标记。由于单标记分析法可测定出未被归类到连锁群、但与QTL有关联的标记,故其可测定到的显著性标记要比区间定位法的多。分析结果表明,控制转光度和茎产量的QTL分散于多个连锁群中,而控制抽穗茎率的QTL相对集中于较少的连锁群中。在利用分子标记进行性状选择时,增加用于辅助选择的标记数目将使入选群体的性状平均值增大,而使误选低值个体的可能性减小。在多标记辅助选择时,各个标记都选用正效应的状态(标记出现或缺失)所得到的标记组合将可选得性状平均值最大的入选群体。 展开更多
关键词 甘蔗 QTL定位 标记辅助选择 区间定位 单标记分析 育种
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尼妥珠单抗对食管鳞癌ECA-109和TE-13细胞放射敏感性的影响及其发生机制 被引量:7
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作者 王军 王雯 +7 位作者 郭银 景绍武 尚凯 苗明昌 王京 武亚晶 刘丽娜 于金明 《中华肿瘤杂志》 CAS CSCD 北大核心 2016年第10期732-738,共7页
目的探讨尼妥珠单抗对食管癌ECA-109和TE-13细胞放射敏感性的影响及其发生机制。方法体外培养人食管癌ECA-109和TE-13细胞,分为空白组、照射组、药物组和联合组(照射+药物治疗)。联合组ECA-109、TE-13细胞在照射前24h给予尼妥珠单... 目的探讨尼妥珠单抗对食管癌ECA-109和TE-13细胞放射敏感性的影响及其发生机制。方法体外培养人食管癌ECA-109和TE-13细胞,分为空白组、照射组、药物组和联合组(照射+药物治疗)。联合组ECA-109、TE-13细胞在照射前24h给予尼妥珠单抗处理,照射后2h收集细胞。克隆形成实验检测尼妥珠单抗对人食管癌ECA.109和TE-13细胞的放射增敏作用。流式细胞术检测各组细胞的凋亡情况。Westernblot检测表皮生长因子受体(EGFR)、磷酸化表皮生长因子受体(p-EGFR)、DNA依赖蛋白激酶催化亚单位(DNA-PKcs)、磷酸化DNA依赖蛋白激酶催化亚单位(p-DNA.PKcs)和磷酸化组蛋白H2AX(7H2AX)的表达。结果ECA-109细胞联合组的准阈剂量(Dq)、平均致死量(D0)和细胞受到2Gy照射后的存活分数(SF2)分别为1.11、1.40和0.42,照射组分别为1.72、2.14和0.66,差异均有统计学意义(均P〈0.05);TE.13细胞联合组的Dq、D0和细胞受到2Gy照射后的SR分别为0.41、0.43和0.40,照射组为0.46、0.65和0.71,差异均有统计学意义(均P〈0.05)。尼妥珠单抗对ECA-109细胞和TE-13细胞的放射增敏比为1.35和1.43。流式细胞仪检测结果显示,ECA-109细胞和TE-13细胞联合组的细胞凋亡率均高于照射组,差异均有统计学意义(均P〈0.05)。Westernblot结果显示,ECA.109细胞和TE.13细胞各组的EGFR和DNA-PKcs的蛋白表达水平均无明显变化(均P〉0.05)。ECA-109细胞和TE,13细胞中,照射组p-EGFR和p-DNA.PKcs的表达水平均高于空白组,照射组和药物组γH2AX的表达水平均高于空白组,差异均有统计学意义(均P〈0.05)。与照射组和药物组比较,联合组p-EGFR和p-DNA.PKcs蛋白的表达水平均明显降低(均P〈0.05),而γH2AX蛋白表达水平均明显升高(均P〈0.05)。结论尼妥珠单抗可提高食管癌ECA-109和TE-13细� 展开更多
关键词 食管肿瘤 受体 表皮生长因子 辐射耐受性 尼妥珠单抗
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假性缺氧驱动“衰老-癌变”的脾肾亏虚病机探讨 被引量:3
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作者 靖林林 马晔 +2 位作者 王浩 William k.k.wu 孙学刚 《中华中医药杂志》 CAS CSCD 北大核心 2018年第11期4870-4873,共4页
脾肾亏虚是"衰老-癌变"进程主要的脏腑病机。衰老过程中衰老代谢物烟酰胺腺嘌呤二核苷酸(NAD+)的降低,肿瘤代谢物(R)-2羟戊二酸[(R)-2HG]、延胡索酸和琥珀酸的累积,体现肾不藏精,脾失健运。缺氧诱导因子1α(HIF-1α)在正常组... 脾肾亏虚是"衰老-癌变"进程主要的脏腑病机。衰老过程中衰老代谢物烟酰胺腺嘌呤二核苷酸(NAD+)的降低,肿瘤代谢物(R)-2羟戊二酸[(R)-2HG]、延胡索酸和琥珀酸的累积,体现肾不藏精,脾失健运。缺氧诱导因子1α(HIF-1α)在正常组织升高,诱导假性缺氧状态,是衰老代谢物与肿瘤代谢物的整合性枢纽,驱动氧化磷酸化向瓦博格样有氧糖酵解的转变。假性缺氧通过表观遗传修饰如组蛋白甲基化、组蛋白乙酰化和DNA甲基化,诱导循序渐进的代谢重编程导致脾肾相互滋生化源不足,产生易于肿瘤发生的微环境,产生肿瘤样状态。健脾补肾可能通过"卡路里限制样效应",改善能量代谢障碍,延缓或逆转衰老-癌变进程。 展开更多
关键词 脾肾亏虚 衰老癌变 假性缺氧 衰老代谢物 肿瘤代谢物 表观遗传学
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光动力诊疗中的5-氨基酮戊酸及酯类衍生物的研究进展 被引量:5
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作者 蒋捷 邹健 +3 位作者 朱杏楣 胡永基 李伟军 黄正 《激光生物学报》 CAS 2019年第4期289-295,共7页
5-氨基酮戊酸(ALA)是体表光动力疗法的一个重要前体药物,通过代谢产物原卟啉Ⅸ(PpⅨ)介导发挥光敏作用。ALA制剂的研发和优化促生了一系列产品和技术,不仅推动了体表光动力疗法的应用,而且ALA介导的PpⅨ荧光还可用于肿瘤的荧光可视化和... 5-氨基酮戊酸(ALA)是体表光动力疗法的一个重要前体药物,通过代谢产物原卟啉Ⅸ(PpⅨ)介导发挥光敏作用。ALA制剂的研发和优化促生了一系列产品和技术,不仅推动了体表光动力疗法的应用,而且ALA介导的PpⅨ荧光还可用于肿瘤的荧光可视化和辅助手术。本文将对光动力诊疗中ALA及其酯类衍生物和PpⅨ的研究进展作一个系统介绍。 展开更多
关键词 5-氨基酮戊酸 酯类衍生物 PpⅨ 光动力诊断 光动力治疗
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香港首套通过污水流动发电的水力涡轮系统 被引量:2
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作者 胡国钊 杜钧明 李宗良 《中国给水排水》 CAS CSCD 北大核心 2020年第22期19-22,共4页
香港特别行政区政府渠务署致力协助减缓全球气候变化,多年来在下辖的一些厂房安装了节能及可再生能源设施。随着香港"净化海港计划第二期甲"的正式启用,渠务署在昂船洲污水处理厂(全港处理污水量最大的污水处理厂)安装了一套... 香港特别行政区政府渠务署致力协助减缓全球气候变化,多年来在下辖的一些厂房安装了节能及可再生能源设施。随着香港"净化海港计划第二期甲"的正式启用,渠务署在昂船洲污水处理厂(全港处理污水量最大的污水处理厂)安装了一套水力涡轮发电系统,利用流动污水的液压能量推动涡轮发电机,继而产生电力供厂内设施使用。对这套系统进行了介绍,包括推行相关工程项目时遇到的挑战,系统设计与施工的考虑和特色,以及系统的运行表现。该系统不仅有助于节省电费开支,还利用水力减少了碳排放。 展开更多
关键词 污水流动发电 水力涡轮系统 碳排放
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A Two-Dimensional Architecture for Fast Large-Scale Trapped-Ion Quantum Computing 被引量:1
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作者 Y.-k.wu L.-M.Duan 《Chinese Physics Letters》 SCIE CAS CSCD 2020年第7期5-10,共6页
Building blocks of quantum computers have been demonstrated in small to intermediate-scale systems.As one of the leading platforms,the trapped ion system has attracted wide attention.A significant challenge in this sy... Building blocks of quantum computers have been demonstrated in small to intermediate-scale systems.As one of the leading platforms,the trapped ion system has attracted wide attention.A significant challenge in this system is to combine fast high-fidelity gates with scalability and convenience in ion trap fabrication.Here we propose an architecture for large-scale quantum computing with a two-dimensional array of atomic ions trapped at such large distance which is convenient for ion-trap fabrication but usually believed to be unsuitable for quantum computing as the conventional gates would be too slow.Using gate operations far outside of the Lamb–Dicke region,we show that fast and robust entangling gates can be realized in any large ion arrays.The gate operations are intrinsically parallel and robust to thermal noise,which,together with their high speed and scalability of the proposed architecture,makes this approach an attractive one for large-scale quantum computing. 展开更多
关键词 QUANTUM COMPUTER operations
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Enhanced mechanical performance of grain boundary precipitation-hardened high-entropy alloys via a phase transformation at grain boundaries 被引量:1
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作者 Y.L.Qi L.Zhao +10 位作者 X.Sun H.X.Zong X.D.Ding F.Jiang H.L.Zhang Y.k.wu L.He F.Liu S.B.Jin G.Sha J.Sun 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第27期271-284,共14页
Grain-boundary(GB)precipitation has a significant adverse effect on plasticity of alloys,which easily leads to catastrophic intergranular failure in safety-critical applications under high external loading.Herein,we r... Grain-boundary(GB)precipitation has a significant adverse effect on plasticity of alloys,which easily leads to catastrophic intergranular failure in safety-critical applications under high external loading.Herein,we report a novel strategy that uses the local stress concentration induced by GB precipitates as a driving force to trigger phase transformation of preset non-equiatomic high-entropy solid-solution phase at GBs.This in situ deformation-induced phase transformation at GBs introduces a well-known effect:transformation-induced plasticity(TRIP),which enables an exceptional elongation to fracture(above 38%)at a high strength(above 1.5 GPa)in a GB precipitation-hardened high-entropy alloy(HEA).The present strategy in terms of"local stress concentration-induced phase transformations at GBs"may provide a fundamental approach by taking advantage of(rather than avoiding)the GB precipitation to gain a superior combination of high strength and high ductility in HEAs. 展开更多
关键词 Non-equiatomic Grain-boundary precipitation High-entropy alloys DUCTILITY Transformation-induced plasticity
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