Background: Community based cervical cancer screening models using self-collection can effectively place the identification of who is positive in the hands of the patient. The key areas we have identified as critical ...Background: Community based cervical cancer screening models using self-collection can effectively place the identification of who is positive in the hands of the patient. The key areas we have identified as critical are 1) education, 2) notification of screening opportunities, 3) registration, 4) submission of samples, 5) receiving results with an explanation, and 6) being advised where to receive evaluation and management from qualified healthcare personnel. Methods: Our primary objectives were to create, register, and pilot a website as a public platform for cervical cancer prevention for both city and rural, individual and organizational application. We selected two sites: Shenzhen City in China as the local city (individual participant) site, and Sangzhi County in Hunan Province as the remote (group management) site. The website was reviewable to all of China, but applications for screening and registration were open only to the women from the 2 pilot sites. In the local site, the women would first sign up (obtain a password) to view the website (www.mcareu.com), and then if they desired, they could register for screening using their true name and their state ID. After an offline confirmation of the address, the sampling kit would arrive. Results were available with additional education and guidance for care also on the website. Findings: 120,099 people nationwide visited the website in 27 months by the end of May, 2015, 1148 women from the sites registered at the website and 87.5% enrolled in the pilot trial. 72.3% of those testing positive returned for management. Virtually 100% of the registration/historical information was entered appropriately and 100% of the samples were handled properly. Interpretation: Web-based decision aids help patients through the uncertainties of healthcare. Applied to cervical cancer screening using self-collection, the effectiveness of the model specifically in respect to accessibility, education, registration, data input, and instructions for positive management was clearly d展开更多
Constructing C–S bonds is important in pharmaceuticals,agriculture,biology,optoelectronic materials and battery technologies[1–3].At present,several strategies have been established in organic synthetic chemistry,su...Constructing C–S bonds is important in pharmaceuticals,agriculture,biology,optoelectronic materials and battery technologies[1–3].At present,several strategies have been established in organic synthetic chemistry,such as sulfa-Michael addition[4],allylic or methane sulfonation[5],and Diels-Alder reactions[6].Although continuous advances have been made,the sustainable implementation of these methods is limited by complicated synthetic procedures,toxic solvents and byproducts,and scalability restrictions.Therefore,developing an alternative strategy to achieve the sustainable construction of C–S bonds under ambient conditions,especially from inexpensive and abundant inorganic reactants,is highly desirable。展开更多
文摘Background: Community based cervical cancer screening models using self-collection can effectively place the identification of who is positive in the hands of the patient. The key areas we have identified as critical are 1) education, 2) notification of screening opportunities, 3) registration, 4) submission of samples, 5) receiving results with an explanation, and 6) being advised where to receive evaluation and management from qualified healthcare personnel. Methods: Our primary objectives were to create, register, and pilot a website as a public platform for cervical cancer prevention for both city and rural, individual and organizational application. We selected two sites: Shenzhen City in China as the local city (individual participant) site, and Sangzhi County in Hunan Province as the remote (group management) site. The website was reviewable to all of China, but applications for screening and registration were open only to the women from the 2 pilot sites. In the local site, the women would first sign up (obtain a password) to view the website (www.mcareu.com), and then if they desired, they could register for screening using their true name and their state ID. After an offline confirmation of the address, the sampling kit would arrive. Results were available with additional education and guidance for care also on the website. Findings: 120,099 people nationwide visited the website in 27 months by the end of May, 2015, 1148 women from the sites registered at the website and 87.5% enrolled in the pilot trial. 72.3% of those testing positive returned for management. Virtually 100% of the registration/historical information was entered appropriately and 100% of the samples were handled properly. Interpretation: Web-based decision aids help patients through the uncertainties of healthcare. Applied to cervical cancer screening using self-collection, the effectiveness of the model specifically in respect to accessibility, education, registration, data input, and instructions for positive management was clearly d
基金the National Postdoctoral Science Foundation of China(2022M722357)to Y.W.for financial support。
文摘Constructing C–S bonds is important in pharmaceuticals,agriculture,biology,optoelectronic materials and battery technologies[1–3].At present,several strategies have been established in organic synthetic chemistry,such as sulfa-Michael addition[4],allylic or methane sulfonation[5],and Diels-Alder reactions[6].Although continuous advances have been made,the sustainable implementation of these methods is limited by complicated synthetic procedures,toxic solvents and byproducts,and scalability restrictions.Therefore,developing an alternative strategy to achieve the sustainable construction of C–S bonds under ambient conditions,especially from inexpensive and abundant inorganic reactants,is highly desirable。
