BACKGROUND Sedation with propofol injections is associated with a risk of addiction,but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme...BACKGROUND Sedation with propofol injections is associated with a risk of addiction,but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme metabolism.Compared to remimazolam,remimazolam benzenesulfonate has a faster effect,is more quickly metabolized,produces inactive metabolites and has weak drug interactions.Thus,remimazolam benzenesulfonate has good effectiveness and safety for diagnostic and operational sedation.AIM To investigate the clinical value of remimazolam benzenesulfonate in cardiac surgery patients under general anesthesia.METHODS A total of 80 patients who underwent surgery in the Department of Cardiothoracic Surgery from August 2020 to April 2021 were included in the study.Using a random number table,patients were divided into two anesthesia induction groups of 40 patients each:remimazolam(0.3 mg/kg remimazolam benzenesulfonate)and propofol(1.5 mg/kg propofol).Hemodynamic parameters,inflammatory stress response indices,respiratory function indices,perioperative indices and adverse reactions in the two groups were monitored over time for comparison.RESULTS At pre-anesthesia induction,the remimazolam and propofol groups did not differ regarding heart rate,mean arterial pressure,cardiac index or volume per wave index.After endotracheal intubation and when the sternum was cut off,mean arterial pressure and volume per wave index were significantly higher in the remimazolam group than in the propofol group(P<0.05).After endotracheal intubation,the oxygenation index and the respiratory index did not differ between the groups.After endotracheal intubation and when the sternum was cut off,the oxygenation index values were significantly higher in the remimazolam group than in the propofol group(P<0.05).Serum interleukin-6 and tumor necrosis factor-αlevels 12 h after surgery were significantly higher than before surgery in both groups(P<0.05).The observation indices were re-examined 2 h after surgery,and the epinephrine,cortisol 展开更多
目的:探讨在胸痛中心模式下急性ST段抬高型心肌梗死(STEMI)患者介入治疗(PCI)绕行急诊的可能性、安全性及预后。方法:选择通过胸痛中心行直接PCI的STEMI患者210例,依据是否绕行急诊科分为绕行组和非绕行组,比较绕行组和非绕行组两组患...目的:探讨在胸痛中心模式下急性ST段抬高型心肌梗死(STEMI)患者介入治疗(PCI)绕行急诊的可能性、安全性及预后。方法:选择通过胸痛中心行直接PCI的STEMI患者210例,依据是否绕行急诊科分为绕行组和非绕行组,比较绕行组和非绕行组两组患者的首次医疗接触至球囊扩张时间(First Medical Contact to balloon,FMC-to-B)、门球时间(door to balloon,D-to-B)、住院期间并发症,术后出院前左室射血分数,术后3个月MACE事件,术后6个月左室射血分数,术后6个月的6分钟步行试验(6 MWT)。结果:绕行组和非绕行组的性别、年龄、合并吸烟、高血压、糖尿病、高脂血症比例以及既往的心肌梗死比例,心肌梗死犯罪血管的分布等差异无统计学意义(P>0.05)。绕行急诊组在FMC-to-B,D-to-B时间上均明显小于非绕行组,差异有统计学意义(P<0.05)。两组患者在住院期间并发症、术后3个月MACE事件、术后出院前左室射血分数比较,差异均没有统计学意义(P>0.05),在术后6个月左室射血分数虽然绕行组要比非绕行组射血分数高,但差异无统计学意义(P>0.05)。术后6个月6 MWT绕行组要优于非绕行组,差异有统计学差异(P<0.05)。结论:绕行急诊行急诊PCI治疗有利于缩短FMC-to-B,D-to-B时间,改善预后,同时安全,风险可控。展开更多
基金The First Affiliated Hospital of Nanchang University Ethics Committee.
文摘BACKGROUND Sedation with propofol injections is associated with a risk of addiction,but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme metabolism.Compared to remimazolam,remimazolam benzenesulfonate has a faster effect,is more quickly metabolized,produces inactive metabolites and has weak drug interactions.Thus,remimazolam benzenesulfonate has good effectiveness and safety for diagnostic and operational sedation.AIM To investigate the clinical value of remimazolam benzenesulfonate in cardiac surgery patients under general anesthesia.METHODS A total of 80 patients who underwent surgery in the Department of Cardiothoracic Surgery from August 2020 to April 2021 were included in the study.Using a random number table,patients were divided into two anesthesia induction groups of 40 patients each:remimazolam(0.3 mg/kg remimazolam benzenesulfonate)and propofol(1.5 mg/kg propofol).Hemodynamic parameters,inflammatory stress response indices,respiratory function indices,perioperative indices and adverse reactions in the two groups were monitored over time for comparison.RESULTS At pre-anesthesia induction,the remimazolam and propofol groups did not differ regarding heart rate,mean arterial pressure,cardiac index or volume per wave index.After endotracheal intubation and when the sternum was cut off,mean arterial pressure and volume per wave index were significantly higher in the remimazolam group than in the propofol group(P<0.05).After endotracheal intubation,the oxygenation index and the respiratory index did not differ between the groups.After endotracheal intubation and when the sternum was cut off,the oxygenation index values were significantly higher in the remimazolam group than in the propofol group(P<0.05).Serum interleukin-6 and tumor necrosis factor-αlevels 12 h after surgery were significantly higher than before surgery in both groups(P<0.05).The observation indices were re-examined 2 h after surgery,and the epinephrine,cortisol
文摘目的:探讨在胸痛中心模式下急性ST段抬高型心肌梗死(STEMI)患者介入治疗(PCI)绕行急诊的可能性、安全性及预后。方法:选择通过胸痛中心行直接PCI的STEMI患者210例,依据是否绕行急诊科分为绕行组和非绕行组,比较绕行组和非绕行组两组患者的首次医疗接触至球囊扩张时间(First Medical Contact to balloon,FMC-to-B)、门球时间(door to balloon,D-to-B)、住院期间并发症,术后出院前左室射血分数,术后3个月MACE事件,术后6个月左室射血分数,术后6个月的6分钟步行试验(6 MWT)。结果:绕行组和非绕行组的性别、年龄、合并吸烟、高血压、糖尿病、高脂血症比例以及既往的心肌梗死比例,心肌梗死犯罪血管的分布等差异无统计学意义(P>0.05)。绕行急诊组在FMC-to-B,D-to-B时间上均明显小于非绕行组,差异有统计学意义(P<0.05)。两组患者在住院期间并发症、术后3个月MACE事件、术后出院前左室射血分数比较,差异均没有统计学意义(P>0.05),在术后6个月左室射血分数虽然绕行组要比非绕行组射血分数高,但差异无统计学意义(P>0.05)。术后6个月6 MWT绕行组要优于非绕行组,差异有统计学差异(P<0.05)。结论:绕行急诊行急诊PCI治疗有利于缩短FMC-to-B,D-to-B时间,改善预后,同时安全,风险可控。
