In this paper,a novel roll-to-roll imprint process is proposed to fabricate gratings in large area. The key challenges in roll-to-roll imprint process,such as the roller mold preparation,imprint system,misalignment of...In this paper,a novel roll-to-roll imprint process is proposed to fabricate gratings in large area. The key challenges in roll-to-roll imprint process,such as the roller mold preparation,imprint system,misalignment of imprint roller and backup roller,and also the imprint pressure,are investigated. Various gratings with different periods and profiles are obtained by the roll-to-roll process. To calibrate the measuring ability of the self-made grating by imprint,a calibration system is built with a dual-frequency laser interferometer. By the calibration,the self-made gratings can achieve ±4μm accuracy in 45mm measuring distance.展开更多
The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global economy.Moreover,after more than 2 years,many populations are still under pressure of infection.Thus,a broad...The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global economy.Moreover,after more than 2 years,many populations are still under pressure of infection.Thus,a broader perspective in developing antiviral strategies is still of great importance.Inspired by the observed multiple benefits of heparin in the treatment of thrombosis,the potential of low molecular weight heparin(LMWH)for the treatment of COVID-19 have been explored.Clinical applications found that LMWH decreased the level of inflammatory cytokines in COVID-19 patients,accordingly reducing lethality.Furthermore,several in vitro studies have demonstrated the important roles of heparan sulfate in SARS-CoV-2 infection and the inhibitory effects of heparin and heparin mimetics in viral infection.These clinical observations and designed studies argue for the potential to develop heparin mimetics as anti-SARS-CoV-2 drug candidates.In this review,we summarize the properties of heparin as an anticoagulant and the pharmaceutical possibilities for the treatment of virus infection,focusing on the perspectives of developing heparin mimetics via chemical synthesis,chemoenzymatic synthesis,and bioengineered production by microbial cell factories.The ultimate goal is to pave the eminent need for exploring novel compounds to treat coronavirus infection-caused diseases.展开更多
Transition metal sulfides are emerging as promising electrode materials for energy storage and conversion.In this work,hierarchical FeS2/C nanospheres are synthesized through a controllable solvothermal method followe...Transition metal sulfides are emerging as promising electrode materials for energy storage and conversion.In this work,hierarchical FeS2/C nanospheres are synthesized through a controllable solvothermal method followed by the annealing process.Spherical FeS2 core is homogeneously coated by thin carbon shell.The hierarchical nanostructure and carbon coating can enhance electron transfer and accommodate the stress originated from the volume change as well as suppress the shuttle effect of polysulfide.Consequently,as the cathode material of lithium ion batteries(LIBs),the FeS2/C nanospheres exhibit high reversible capacity of 676 m Ahg^-1 and excellent cycling life with the capacity retention of 97.1%after100 cycles.In addition,even at the high current density of 1.8 C,a reversible capacity of 437 m Ahg^-1 is obtained for the FeS2/C nanospheres,demonstrating its great prospect for practical applications in highperformance LIBs.展开更多
UV-nanoimprint lithography (UV-NIL) using a soft mold is a promising technique with low cost and high throughput for producing the submicron scale large-area patterns. However, the deformations of the soft mold during...UV-nanoimprint lithography (UV-NIL) using a soft mold is a promising technique with low cost and high throughput for producing the submicron scale large-area patterns. However, the deformations of the soft mold during imprinting process which can cause serious consequences have to be understood for the practical application of the process. This paper investigated the deformation of the soft mold by theoretical analyses, numerical simulations, and experimental studies. We simulated the mold deformation using a simplified model and finite element method. The simulation and the related experimental results agree well with each other. Through the investigation, the mechanism and affected factors of the mold deformation are revealed, and some useful conclusions have been achieved. These results will be valuable in optimizing the imprinting process conditions and mold design for improving the quality of transferred patterns.展开更多
Introduction With the remarkable properties in mechanical,electronic and magnetic,fabrication of carbon nanotube (CNT) arrays has drawn ever-increasing worldwide attention in application of field emission display (FED...Introduction With the remarkable properties in mechanical,electronic and magnetic,fabrication of carbon nanotube (CNT) arrays has drawn ever-increasing worldwide attention in application of field emission display (FED) and展开更多
基金The Major Special Projects of Ministry of Science and Technology of China(No.2011ZX04014-071)National Natural Science Foundation of China(No.51275400)
文摘In this paper,a novel roll-to-roll imprint process is proposed to fabricate gratings in large area. The key challenges in roll-to-roll imprint process,such as the roller mold preparation,imprint system,misalignment of imprint roller and backup roller,and also the imprint pressure,are investigated. Various gratings with different periods and profiles are obtained by the roll-to-roll process. To calibrate the measuring ability of the self-made grating by imprint,a calibration system is built with a dual-frequency laser interferometer. By the calibration,the self-made gratings can achieve ±4μm accuracy in 45mm measuring distance.
基金support from the National Key Research and Development Program of China (2021YFF0600700,2020YFA090032 and 2019YFA0906201)the Swedish research council (2020-05759)the National Natural Science Foundation of China (31720103901,31961133004,21907031,21977029,22108266).
文摘The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global economy.Moreover,after more than 2 years,many populations are still under pressure of infection.Thus,a broader perspective in developing antiviral strategies is still of great importance.Inspired by the observed multiple benefits of heparin in the treatment of thrombosis,the potential of low molecular weight heparin(LMWH)for the treatment of COVID-19 have been explored.Clinical applications found that LMWH decreased the level of inflammatory cytokines in COVID-19 patients,accordingly reducing lethality.Furthermore,several in vitro studies have demonstrated the important roles of heparan sulfate in SARS-CoV-2 infection and the inhibitory effects of heparin and heparin mimetics in viral infection.These clinical observations and designed studies argue for the potential to develop heparin mimetics as anti-SARS-CoV-2 drug candidates.In this review,we summarize the properties of heparin as an anticoagulant and the pharmaceutical possibilities for the treatment of virus infection,focusing on the perspectives of developing heparin mimetics via chemical synthesis,chemoenzymatic synthesis,and bioengineered production by microbial cell factories.The ultimate goal is to pave the eminent need for exploring novel compounds to treat coronavirus infection-caused diseases.
基金funded by the Natural Science Foundation of Zhejiang Provincial (No. LQ17E020003)the National Natural Science Foundation of China (No. 51804092)
文摘Transition metal sulfides are emerging as promising electrode materials for energy storage and conversion.In this work,hierarchical FeS2/C nanospheres are synthesized through a controllable solvothermal method followed by the annealing process.Spherical FeS2 core is homogeneously coated by thin carbon shell.The hierarchical nanostructure and carbon coating can enhance electron transfer and accommodate the stress originated from the volume change as well as suppress the shuttle effect of polysulfide.Consequently,as the cathode material of lithium ion batteries(LIBs),the FeS2/C nanospheres exhibit high reversible capacity of 676 m Ahg^-1 and excellent cycling life with the capacity retention of 97.1%after100 cycles.In addition,even at the high current density of 1.8 C,a reversible capacity of 437 m Ahg^-1 is obtained for the FeS2/C nanospheres,demonstrating its great prospect for practical applications in highperformance LIBs.
基金Supported by the 973 Basics Science Research Program of China (Grant No.2003CB716203)the National Natural Science Foundation of China (Grant No.50775176)the Natural Science Foundation of Shandong Province (Grant No.Y2007F49)
文摘UV-nanoimprint lithography (UV-NIL) using a soft mold is a promising technique with low cost and high throughput for producing the submicron scale large-area patterns. However, the deformations of the soft mold during imprinting process which can cause serious consequences have to be understood for the practical application of the process. This paper investigated the deformation of the soft mold by theoretical analyses, numerical simulations, and experimental studies. We simulated the mold deformation using a simplified model and finite element method. The simulation and the related experimental results agree well with each other. Through the investigation, the mechanism and affected factors of the mold deformation are revealed, and some useful conclusions have been achieved. These results will be valuable in optimizing the imprinting process conditions and mold design for improving the quality of transferred patterns.
基金This work was supported by 973 Basics Science Research Program （grant No. 2003CBT16203）the National Science Foundation of China （grant No. 50505037）+2 种基金 863 Hi-Tech Program （grant No. 2006AA04Z322 and No. 2006AA05Z411）Xi'An AM Foundation （grant No. XA-AM-200505 and No. XA-AM-200609 ）ShanXi Province Foundation （grant No. 2006E109).
文摘Introduction With the remarkable properties in mechanical,electronic and magnetic,fabrication of carbon nanotube (CNT) arrays has drawn ever-increasing worldwide attention in application of field emission display (FED) and
