An earthquake with Ms5.8 occurred on 10 March 2011 in Yingjiang county, western Yunnan, China. This earthquake caused 25 deaths and over 250 injuries. In order to better understand the seismotectonics in the region, w...An earthquake with Ms5.8 occurred on 10 March 2011 in Yingjiang county, western Yunnan, China. This earthquake caused 25 deaths and over 250 injuries. In order to better understand the seismotectonics in the region, we collected the arrival time data from the Yunnan seismic observational bulletins during 1 January to 25 March 2011, and precisely hand-picked the arrival times from high-quality seismograms that were recorded by the temporary seismic stations deployed by our Institute of Crustal Dynamics, China Earthquake Administration. Using these arrival times, we relocated all the earthquakes including the Yingjiang mainshock and its aftershocks using the double-difference relocation algorithm. Our results show that the relocated earthquakes dominantly occurred along the ENE direction and formed an upside-down bow-shaped structure in depth. It is also observed that after the Yingjiang mainshock, some aftershocks extended toward the SSE over about 10 km. These results may indicate that the Yingjiang mainshock ruptured a conjugate fault system consisting of the ENE trending Da Yingjiang fault and a SSE trending blind fault. Such structural features could contribute to severely seismic hazards during the moderate-size Yingjiang earthquake.展开更多
Achieving simultaneous polarization and wavefront control,especially circular polarization with the auxiliary degree of freedom of light and spin angular momentum,is of fundamental importance in many optical applicati...Achieving simultaneous polarization and wavefront control,especially circular polarization with the auxiliary degree of freedom of light and spin angular momentum,is of fundamental importance in many optical applications.Interferences are typically undesirable in highly integrated photonic circuits and metasurfaces.Here,we propose an interference-assisted metasurface-multiplexer(meta-plexer)that counterintuitively exploits constructive and destructive interferences between hybrid meta-atoms and realizes independent spin-selective wavefront manipulation.Such kaleidoscopic meta-plexers are experimentally demonstrated via two types of single-layer spinwavefront multiplexers that are composed of spatially rotated anisotropic meta-atoms.One type generates a spinselective Bessel-beam wavefront for spin-down light and a low scattering cross-section for stealth for spin-up light.The other type demonstrates versatile control of the vortex wavefront,which is also characterized by the orbital angular momentum of light,with frequency-switchable numbers of beams under linearly polarized wave excitation.Our findings offer a distinct interference-assisted concept for realizing advanced multifunctional photonics with arbitrary and independent spin-wavefront features.A variety of applications can be readily anticipated in optical diodes,isolators,and spin-Hall meta-devices without cascading bulky optical elements.展开更多
Chiglitazar(Carfloglitazar)is a novel peroxisome proliferator-activated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes.In this rand...Chiglitazar(Carfloglitazar)is a novel peroxisome proliferator-activated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes.In this randomized phase 3 trial,we compared the efficacy and safety of chiglitazar with sitagliptin in patients with type 2 diabetes who had insufficient glycemic control despite a strict diet and exercise regimen.Eligible patients were randomized(1:1:1)to receive chiglitazar 32 mg(n=245),chiglitazar 48 mg(n=246),or sitagliptin 100 mg(n=248)once daily for 24 weeks.The primary endpoint was the change in glycosylated hemoglobin A_(1C)(HbA_(1c))from baseline at week 24 with the non-inferiority of chiglitazar over sitagliptin.Both chiglitazar and sitagliptin significantly reduced HbA1c at week 24 with values of-1.40%,-1.47%,and-1.39%for chiglitazar 32 mg,chiglitazar 48 mg,and sitagliptin 100 mg,respectively.Chiglitazar 32 and 48 mg were both non-inferior to sitagliptin 100 mg,with mean differences of-0.04%(95%confidential interval(Cl)-0.22 to 0.15)and-0.08%(95%Cl-0.27 to 0.10),respectively.Compared with sitagliptin,greater reduction in fasting and 2-h postprandial plasma glucose and fasting insulin was observed with chiglitazar.Overall adverse event rates were similar between the groups.A small increase in mild edema in the chiglitazar 48 mg group and slight weight gain in both chiglitazar groups were reported.The overall results demonstrated that chiglitazar possesses good efficacy and safety profile in patients with type 2 diabetes inadequately controlled with lifestyle interventions,thereby providing adequate supporting evidence for using this PPAR pan-agonist as a treatment option for type 2 diabetes.展开更多
小驳骨为爵床科药用植物,具有祛瘀止痛、续筋接骨的功效,长期以来被用于跌打损伤、筋伤骨折、风湿骨痛、血瘀经闭和产后腹痛等疾病的治疗。通过搜索中国知网、PubMed、Web of Science等数据库,查找国内外已经发表的小驳骨相关文献,对小...小驳骨为爵床科药用植物,具有祛瘀止痛、续筋接骨的功效,长期以来被用于跌打损伤、筋伤骨折、风湿骨痛、血瘀经闭和产后腹痛等疾病的治疗。通过搜索中国知网、PubMed、Web of Science等数据库,查找国内外已经发表的小驳骨相关文献,对小驳骨近二十年的化学成分和生物活性研究进行系统地梳理、归纳,发现目前已从小驳骨中分离出超过100种化合物,包括萜类、黄酮类、苯丙素类、木质素类、香豆素类和生物碱等。小驳骨提取物具有显著的生物活性,如抗炎、抗氧化等,其抗炎作用机制可能与调节炎症因子水平、抑制相关信号通路或相关蛋白表达等有关。可为小驳骨资源后续深入系统地研究和临床开发提供科学依据和理论参考。展开更多
In this paper,we present a unified finite volume method preserving discrete maximum principle(DMP)for the conjugate heat transfer problems with general interface conditions.We prove the existence of the numerical solu...In this paper,we present a unified finite volume method preserving discrete maximum principle(DMP)for the conjugate heat transfer problems with general interface conditions.We prove the existence of the numerical solution and the DMP-preserving property.Numerical experiments show that the nonlinear iteration numbers of the scheme in[24]increase rapidly when the interfacial coefficients decrease to zero.In contrast,the nonlinear iteration numbers of the unified scheme do not increase when the interfacial coefficients decrease to zero,which reveals that the unified scheme is more robust than the scheme in[24].The accuracy and DMP-preserving property of the scheme are also veri ed in the numerical experiments.展开更多
In this paper,we construct a new cell-centered nonlinear finite volume scheme that preserves the extremum principle for heterogeneous anisotropic diffusion equation on distorted meshes.We introduce a new nonlinear app...In this paper,we construct a new cell-centered nonlinear finite volume scheme that preserves the extremum principle for heterogeneous anisotropic diffusion equation on distorted meshes.We introduce a new nonlinear approach to construct the conservative flux,that is,a linear second order flux is firstly given and a nonlinear conservative flux is then constructed by using an adaptive method and a nonlinear weighted method.Our new scheme does not need to use the convex combination of the cell-center unknowns to approximate the auxiliary unknowns,so it can deal with the problem with general discontinuous coefficients.Numerical results show that our new scheme performs more robust than some existing schemes on highly distorted meshes.展开更多
The carbuncle phenomenon has been regarded as a spurious solution produced by most of contact-preserving methods.The hybrid method of combining high resolution flux with more dissipative solver is an attractive attemp...The carbuncle phenomenon has been regarded as a spurious solution produced by most of contact-preserving methods.The hybrid method of combining high resolution flux with more dissipative solver is an attractive attempt to cure this kind of non-physical phenomenon.In this paper,a matrix-based stability analysis for 2-D Euler equations is performed to explore the cause of instability of numerical schemes.By combining the Roe with HLL flux in different directions and different flux components,we give an interesting explanation to the linear numerical instability.Based on such analysis,some hybrid schemes are compared to illustrate different mechanisms in controlling shock instability.Numerical experiments are presented to verify our analysis results.The conclusion is that the scheme of restricting directly instability source is more stable than other hybrid schemes.展开更多
In this paper we construct the suitable weak solution for the initial-boundary value problem of the Boussinesq equations and obtain some properties for these solutions.Also in the case of a two dimensional space the u...In this paper we construct the suitable weak solution for the initial-boundary value problem of the Boussinesq equations and obtain some properties for these solutions.Also in the case of a two dimensional space the uniqueness of weak solution is proved.展开更多
For a new nonlinear iterative method named as Picard-Newton(P-N)iterative method for the solution of the time-dependent reaction-diffusion systems,which arise in non-equilibrium radiation diffusion applications,two ti...For a new nonlinear iterative method named as Picard-Newton(P-N)iterative method for the solution of the time-dependent reaction-diffusion systems,which arise in non-equilibrium radiation diffusion applications,two time step control methods are investigated and a study of temporal accuracy of a first order time integration is presented.The non-equilibrium radiation diffusion problems with flux limiter are considered,which appends pesky complexity and nonlinearity to the diffusion coef-ficient.Numerical results are presented to demonstrate that compared with Picard method,for a desired accuracy,significant increase in solution efficiency can be obtained by Picard-Newton method with the suitable time step size selection.展开更多
基金supported by National Natural Science Foundation of China(Nos.40974201 and 40774044)to J.Lei
文摘An earthquake with Ms5.8 occurred on 10 March 2011 in Yingjiang county, western Yunnan, China. This earthquake caused 25 deaths and over 250 injuries. In order to better understand the seismotectonics in the region, we collected the arrival time data from the Yunnan seismic observational bulletins during 1 January to 25 March 2011, and precisely hand-picked the arrival times from high-quality seismograms that were recorded by the temporary seismic stations deployed by our Institute of Crustal Dynamics, China Earthquake Administration. Using these arrival times, we relocated all the earthquakes including the Yingjiang mainshock and its aftershocks using the double-difference relocation algorithm. Our results show that the relocated earthquakes dominantly occurred along the ENE direction and formed an upside-down bow-shaped structure in depth. It is also observed that after the Yingjiang mainshock, some aftershocks extended toward the SSE over about 10 km. These results may indicate that the Yingjiang mainshock ruptured a conjugate fault system consisting of the ENE trending Da Yingjiang fault and a SSE trending blind fault. Such structural features could contribute to severely seismic hazards during the moderate-size Yingjiang earthquake.
基金supported by the National Natural Science Foundation of China(61501499,11634010)Youth Talent Lifting Project of the China Association for Science and Technology(17-JCJQ-QT-003)+7 种基金National Defense Foundation of China(2201078)Key Program of Natural Science Foundation of Shaanxi Province(2017KJXX-24)China Scholarship Fund(201703170022)Aviation Science Foundation of China(20161996009)supports from the National Natural Science Foundation of China(61631007 and 61571117)the National Key Research and Development Program of China(2017YFA0700201,2017YFA0700202,2017YFA0700201)the 111 Project(111-2-05)the financial support from the National Research Foundation,Prime Minister’s Office,Singapore under its Competitive Research Program(CRP award NRF-CRP15-2015-03).
文摘Achieving simultaneous polarization and wavefront control,especially circular polarization with the auxiliary degree of freedom of light and spin angular momentum,is of fundamental importance in many optical applications.Interferences are typically undesirable in highly integrated photonic circuits and metasurfaces.Here,we propose an interference-assisted metasurface-multiplexer(meta-plexer)that counterintuitively exploits constructive and destructive interferences between hybrid meta-atoms and realizes independent spin-selective wavefront manipulation.Such kaleidoscopic meta-plexers are experimentally demonstrated via two types of single-layer spinwavefront multiplexers that are composed of spatially rotated anisotropic meta-atoms.One type generates a spinselective Bessel-beam wavefront for spin-down light and a low scattering cross-section for stealth for spin-up light.The other type demonstrates versatile control of the vortex wavefront,which is also characterized by the orbital angular momentum of light,with frequency-switchable numbers of beams under linearly polarized wave excitation.Our findings offer a distinct interference-assisted concept for realizing advanced multifunctional photonics with arbitrary and independent spin-wavefront features.A variety of applications can be readily anticipated in optical diodes,isolators,and spin-Hall meta-devices without cascading bulky optical elements.
基金the Chinese National and Provincial Major Project for New Drug Innovation(National:2008ZX09101-002,2013ZX09401301Provincial:2011A080501010)Shenzhen Municipal Major Project(2010-1746)。
文摘Chiglitazar(Carfloglitazar)is a novel peroxisome proliferator-activated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes.In this randomized phase 3 trial,we compared the efficacy and safety of chiglitazar with sitagliptin in patients with type 2 diabetes who had insufficient glycemic control despite a strict diet and exercise regimen.Eligible patients were randomized(1:1:1)to receive chiglitazar 32 mg(n=245),chiglitazar 48 mg(n=246),or sitagliptin 100 mg(n=248)once daily for 24 weeks.The primary endpoint was the change in glycosylated hemoglobin A_(1C)(HbA_(1c))from baseline at week 24 with the non-inferiority of chiglitazar over sitagliptin.Both chiglitazar and sitagliptin significantly reduced HbA1c at week 24 with values of-1.40%,-1.47%,and-1.39%for chiglitazar 32 mg,chiglitazar 48 mg,and sitagliptin 100 mg,respectively.Chiglitazar 32 and 48 mg were both non-inferior to sitagliptin 100 mg,with mean differences of-0.04%(95%confidential interval(Cl)-0.22 to 0.15)and-0.08%(95%Cl-0.27 to 0.10),respectively.Compared with sitagliptin,greater reduction in fasting and 2-h postprandial plasma glucose and fasting insulin was observed with chiglitazar.Overall adverse event rates were similar between the groups.A small increase in mild edema in the chiglitazar 48 mg group and slight weight gain in both chiglitazar groups were reported.The overall results demonstrated that chiglitazar possesses good efficacy and safety profile in patients with type 2 diabetes inadequately controlled with lifestyle interventions,thereby providing adequate supporting evidence for using this PPAR pan-agonist as a treatment option for type 2 diabetes.
文摘小驳骨为爵床科药用植物,具有祛瘀止痛、续筋接骨的功效,长期以来被用于跌打损伤、筋伤骨折、风湿骨痛、血瘀经闭和产后腹痛等疾病的治疗。通过搜索中国知网、PubMed、Web of Science等数据库,查找国内外已经发表的小驳骨相关文献,对小驳骨近二十年的化学成分和生物活性研究进行系统地梳理、归纳,发现目前已从小驳骨中分离出超过100种化合物,包括萜类、黄酮类、苯丙素类、木质素类、香豆素类和生物碱等。小驳骨提取物具有显著的生物活性,如抗炎、抗氧化等,其抗炎作用机制可能与调节炎症因子水平、抑制相关信号通路或相关蛋白表达等有关。可为小驳骨资源后续深入系统地研究和临床开发提供科学依据和理论参考。
基金National Natural Science Foundation of China(11971069,12071045)Foundation of CAEP(CX20210042)Science Challenge Project(No.TZ2016002).
文摘In this paper,we present a unified finite volume method preserving discrete maximum principle(DMP)for the conjugate heat transfer problems with general interface conditions.We prove the existence of the numerical solution and the DMP-preserving property.Numerical experiments show that the nonlinear iteration numbers of the scheme in[24]increase rapidly when the interfacial coefficients decrease to zero.In contrast,the nonlinear iteration numbers of the unified scheme do not increase when the interfacial coefficients decrease to zero,which reveals that the unified scheme is more robust than the scheme in[24].The accuracy and DMP-preserving property of the scheme are also veri ed in the numerical experiments.
基金This work was supported by the National Natural Science Foundation of China(Nos.11971069,12071045)the Scientific Research Foundation of NUAA No.YAH21109.
文摘In this paper,we construct a new cell-centered nonlinear finite volume scheme that preserves the extremum principle for heterogeneous anisotropic diffusion equation on distorted meshes.We introduce a new nonlinear approach to construct the conservative flux,that is,a linear second order flux is firstly given and a nonlinear conservative flux is then constructed by using an adaptive method and a nonlinear weighted method.Our new scheme does not need to use the convex combination of the cell-center unknowns to approximate the auxiliary unknowns,so it can deal with the problem with general discontinuous coefficients.Numerical results show that our new scheme performs more robust than some existing schemes on highly distorted meshes.
基金supported by the National Natural Science Foundation of China(11071025)the Foundation of CAEP(2010A0202010)the Foundation of National Key Laboratory of Science and Technology Computation Physics and the Defense Industrial Technology Development Program(B1520110011).
文摘The carbuncle phenomenon has been regarded as a spurious solution produced by most of contact-preserving methods.The hybrid method of combining high resolution flux with more dissipative solver is an attractive attempt to cure this kind of non-physical phenomenon.In this paper,a matrix-based stability analysis for 2-D Euler equations is performed to explore the cause of instability of numerical schemes.By combining the Roe with HLL flux in different directions and different flux components,we give an interesting explanation to the linear numerical instability.Based on such analysis,some hybrid schemes are compared to illustrate different mechanisms in controlling shock instability.Numerical experiments are presented to verify our analysis results.The conclusion is that the scheme of restricting directly instability source is more stable than other hybrid schemes.
文摘In this paper we construct the suitable weak solution for the initial-boundary value problem of the Boussinesq equations and obtain some properties for these solutions.Also in the case of a two dimensional space the uniqueness of weak solution is proved.
基金supported by the Basic Research Project of National Defence(B1520110011)the Foundation of CAEP(2010A0202010),the Foundation of National Key Laboratory of Science and Technology on Computational Physics。
文摘For a new nonlinear iterative method named as Picard-Newton(P-N)iterative method for the solution of the time-dependent reaction-diffusion systems,which arise in non-equilibrium radiation diffusion applications,two time step control methods are investigated and a study of temporal accuracy of a first order time integration is presented.The non-equilibrium radiation diffusion problems with flux limiter are considered,which appends pesky complexity and nonlinearity to the diffusion coef-ficient.Numerical results are presented to demonstrate that compared with Picard method,for a desired accuracy,significant increase in solution efficiency can be obtained by Picard-Newton method with the suitable time step size selection.
