Organophosphorus pesticides （OPs） are one of the most regular pollutants and frequently detected in the contaminated sites, so developing an efficient method for the treatment of OPs is highly required. The aim of t...Organophosphorus pesticides （OPs） are one of the most regular pollutants and frequently detected in the contaminated sites, so developing an efficient method for the treatment of OPs is highly required. The aim of the present study was to compare the effectiveness of persulfate （PS） activation and Fenton reaction in remediating the soil polluted with OPs. The polluted soil used in this study was sampled from an abandoned insecticide factory in Nantong, Jiangsu Province of China, mainly containing chloropyrifos （CP） and 4-bromo-2-chlorophenol （BCP, the raw material of profenofos） with total concentration of about 30 000 mg kg- 1. The results showed that both BCP and CP were efficiently degraded by base activation of PS, and increasing the ratio of NaOH/PS enhanced CP degradation, but slightly decreased BCP degradation. The greatest degradation rates for CP and BCP were 92% and 97%, respectively, with 7.0 tool L-1 NaOH and 0.21 tool L-1 PS and a soil-to-liquid ratio of 1：1. Furthermore, ferrous iron activation of PS also degraded BCP efficiently, but only 60% of CP was degraded under the same reaction conditions. These results indicated that base activation of PS was more feasible than Fe2＋ activation and Fenton reaction in remediating the soil polluted with OPs. The high degradation rate for CP may be linked to the initial hydrolyzation of CP by base to 3,5,6-trichloro-2-pyridinol, which can be further rapidly degraded by free radicals generated from base activation of PS.展开更多
Central Asia,a crucible of prehistoric and historical Trans-Eurasian interactions,has been pivotal in shaping cultural exchanges,population dynamics,and genetic admixture.Recent insights from ancient DNA studies have ...Central Asia,a crucible of prehistoric and historical Trans-Eurasian interactions,has been pivotal in shaping cultural exchanges,population dynamics,and genetic admixture.Recent insights from ancient DNA studies have shed light on the extensive population turnover within this region,encompassing a spectrum of groups from Paleolithic huntergatherers to Holocene herders and the nomadic pastoralist empires of historical times.The genomic analysis of ancient pathogens across the Eurasian steppe has further deepened our understanding of pathogen origins,clonal expansions,and the intricate processes of host-pathogen coevolution in relation to varying pathogen exposures and their spread.We consolidate the latest findings pertaining to the ancient human and pathogen genomes of Central Asia,elucidating their profound influence on the genomic tapestry of contemporary Central Asians.A notable gap in the current genomic databases for Central Asia is underscored,particularly within the scope of genomics-driven precision medicine.We stress the urgent need for the development of extensive,region-specific genomic resources that hold promise for revealing the genetic blueprints underlying human traits and diseases,refining polygenic scoring models for predictive medicine,and bolstering genomic research endeavors across Central Asia.展开更多
The density of Ni-AI alloys in both liquid state and solid-liquid coexistence state was measured with a modified pycnometric method. It was found that the density of Ni-AI alloys decreases with increasing temperature ...The density of Ni-AI alloys in both liquid state and solid-liquid coexistence state was measured with a modified pycnometric method. It was found that the density of Ni-AI alloys decreases with increasing temperature and Al concentration in the alloys. The molar volume of liquid Ni-AI binary alloys increases with the increase of temperature and Al concentration. The partial molar volume of Al in Ni-AI binary alloy was calculated approximately. The molar volume of liquid Ni-AI alloy determined in the present work shows a negative deviation from the ideal linear molar volume.展开更多
Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and funct...Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and functional genomics tools has enabled the systematic identification of functional noncoding variants. These variants can impact gene expression, regulation, and chromatin conformation, thereby contributing to disease pathogenesis. Understanding the mechanisms that underlie the impact of noncoding variants on genetic diseases is indispensable for the development of precisely targeted therapies and the implementation of personalized medicine strategies. The intricacies of noncoding regions introduce a multitude of challenges and research opportunities. In this review, we introduce a spectrum of noncoding variants involved in genetic diseases, along with research strategies and advanced technologies for their precise identification and in-depth understanding of the complexity of the noncoding genome. We will delve into the research challenges and propose potential solutions for unraveling the genetic basis of rare and complex diseases.展开更多
The application of whole genome sequencing is expanding in clinical diagnostics across various genetic disorders, and the significance of non-coding variants in penetrant diseases is increasingly being demonstrated. T...The application of whole genome sequencing is expanding in clinical diagnostics across various genetic disorders, and the significance of non-coding variants in penetrant diseases is increasingly being demonstrated. Therefore, it is urgent to improve the diagnostic yield by exploring the pathogenic mechanisms of variants in non-coding regions. However, the interpretation of non-coding variants remains a significant challenge, due to the complex functional regulatory mechanisms of non-coding regions and the current limitations of available databases and tools. Hence, we develop the non-coding variant annotation database (NCAD, http://www.ncawdb.net/), encompassing comprehensive insights into 665,679,194 variants, regulatory elements, and element interaction details. Integrating data from 96 sources, spanning both GRCh37 and GRCh38 versions, NCAD v1.0 provides vital information to support the genetic diagnosis of non-coding variants, including allele frequencies of 12 diverse populations, with a particular focus on the population frequency information for 230,235,698 variants in 20,964 Chinese individuals. Moreover, it offers prediction scores for variant functionality, five categories of regulatory elements, and four types of non-coding RNAs. With its rich data and comprehensive coverage, NCAD serves as a valuable platform, empowering researchers and clinicians with profound insights into non-coding regulatory mechanisms while facilitating the interpretation of non-coding variants.展开更多
The density of liquid binary Ni-Mo alloys with molybdenum concentration from 0 to 20% (mass fraction) wasmeasured by a modified sessile drop method. It has been found that the density of the liquid Ni-Mo alloys decrea...The density of liquid binary Ni-Mo alloys with molybdenum concentration from 0 to 20% (mass fraction) wasmeasured by a modified sessile drop method. It has been found that the density of the liquid Ni-Mo alloys decreaseswith increasing temperature, but increases with the increase of molybdenum concentration in the alloys. The molarvolume of liquid Ni-Mo binary alloys increases with the increase of temperature and molybdenum concentration. Thepartial molar volume of molybdenum in Ni-Mo binary alloy has been approximately calculated as [13.18-2.65×10^(-3)T+(-47.94+3.10×10^(-2)T)×10^(-2)X_(Mo)]×10^(-6)m^3·mol^(-1). The molar volume of Ni-Mo alloy determined inthe present work shows a negative deviation from the ideal linear mixing molar volume.展开更多
FeAl/TiC composites were fabricated by hot pressing blended elemental powders. The effects of Ni-doping on thedensification and mechanical properties of the composites were studied. Results show that the density of th...FeAl/TiC composites were fabricated by hot pressing blended elemental powders. The effects of Ni-doping on thedensification and mechanical properties of the composites were studied. Results show that the density of the composites decreases with the content of TiC increasing, and the addition of Ni significantly improves the densificationprocess by enhancing mass transfer in the bonding phase. The mechanical properties of the composites are closelyrelated with their porosity. Besides increasing the density of the composites, the addition of Ni improves the mechanical properties by other three effects: solution-strengthening the bonding phase, strengthening the FeAI-TiC interfaceand increasing ductile fracture in FeAl phase.展开更多
Epidermal growth factor receptor(EGFR)is reportedly overexpressed in most esophageal squamous cell carcinoma(ESCC)patients,but anti-EGFR treatments offer limited survival benefits.Our preclinical data showed the promi...Epidermal growth factor receptor(EGFR)is reportedly overexpressed in most esophageal squamous cell carcinoma(ESCC)patients,but anti-EGFR treatments offer limited survival benefits.Our preclinical data showed the promising antitumor activity of afatinib in EGFR-overexpressing ESCC.This proof-of-concept,phase II trial assessed the efficacy and safety of afatinib in pretreated metastatic ESCC patients(n=41)with EGFR overexpression(NCT03940976).The study met its primary endpoint,with a confirmed objective response rate(ORR)of 39%in 38 efficacy-evaluable patients and a median overall survival of 7.8 months,with a manageable toxicity profile.Transcriptome analysis of pretreatment tumors revealed that neurotrophic receptor tyrosine kinase 2(NTRK2)was negatively associated with afatinib sensitivity and might serve as a predictive biomarker,irrespective of EGFR expression.Notably,knocking down or inhibiting NTRK2 sensitized ESCC cells to afatinib treatment.Our study provides novel findings on the molecular factors underlying afatinib resistance and indicates that afatinib has the potential to become an important treatment for metastatic ESCC patients.展开更多
Nitrated polycyclic aromatic hydrocarbons(NPAHs)are widespread organic pollutants that possess carcinogenic and mutagenic properties,so they may pose a risk to the environment and human health.In this study,the concen...Nitrated polycyclic aromatic hydrocarbons(NPAHs)are widespread organic pollutants that possess carcinogenic and mutagenic properties,so they may pose a risk to the environment and human health.In this study,the concentrations of 15 NPAHs and 16 polycyclic aromatic hydrocarbons(PAHs)in 30 surface water samples and 26 sediment samples were measured in 2018 from the Taige Canal,one of the main rivers flowing into Taihu Lake,China.The total NPAH concentrations in water and sediment ranged from 14.7 to 235 ng/L and 22.9 to 96.5 ng/g dw,respectively.9-nitrophenanthrene(nd–76.3 ng/L)was the dominant compound in surface water,while 2+3-nitrofluoranthene(1.73–18.1 ng/g dw)dominated in sediment.Among PAHs,concentration ranging from 1,097 to 2,981 ng/L and 1,089 to 4,489 ng/g dw in surface water and sediment,respectively.There was a strong positive correlation between the log octanol-water partition coefficient(Kow)and log sediment-water partition coefficient due to hydrophobic interaction.The fugacity fraction value increased with the decrease of log Kow,and chrysene was transferred from water into sediment.The residual NPAHs in surface water and sediment of the Taige Canal have partial correlation.Diesel engine and coal combustion emissions were probably the principal sources of NPAHs in surface water and sediment.The results of ecological risk assessment showed that some NPAHs inwater(e.g,1-nitropyrene and 6-nitrochrysene)and sediment(e.g.,2-nitrobiphenyl,5-nitroacenaphthene,9-nitrophenanthrene and 2+3-nitrofluoranthene)had moderate ecological risks,which should be of concern.展开更多
Density of molten Ni and Ni-W alloys was measured in the temperature range of 1773-1873 K with a sessile drop method. The density of molten Ni and Ni-W alloys trends to decrease with increasing temperature. The densit...Density of molten Ni and Ni-W alloys was measured in the temperature range of 1773-1873 K with a sessile drop method. The density of molten Ni and Ni-W alloys trends to decrease with increasing temperature. The density and molar volume of the alloys trend to increase with increasing W concentration in the alloys. The calculation result shows an ideal mixing of Ni-W alloys.展开更多
The molecular phylogenetic trees of 10 species representing 6 genera of the family Rhizophoraceae have been constructed using the sequences of chloroplast genes ma/K and rbcL as well as the ITS regions of nuclear ribo...The molecular phylogenetic trees of 10 species representing 6 genera of the family Rhizophoraceae have been constructed using the sequences of chloroplast genes ma/K and rbcL as well as the ITS regions of nuclear ribosomal DMA. Relative-rate tests between lineages in these phylogenetic trees have been performed. On the basis of the results of the relative-rate tests and related molecular evolutionary rate data, the divergence times between the lineages are estimated as follows: ( i) the first divergence time in these genera is 132.25 million years ago (mya); (ii) the average divergence time between two tribes, i.e. inland Legnotideae (except Carallia brachiata) and mangrove Rhizophoreae, is 64.13 mya; and (iii) the average divergence time between two inland species, C. garciniaefolia and C. pectinifolia, is 19.92 mya.展开更多
A simple method for preparation of template DNA suitable for PCR amplification from herbarium samples and plant tissues rich in byproducts, e.g. polysaccha-rides, tannins, polyphenolic, and terpenoids compounds, is de...A simple method for preparation of template DNA suitable for PCR amplification from herbarium samples and plant tissues rich in byproducts, e.g. polysaccha-rides, tannins, polyphenolic, and terpenoids compounds, is described. The total DNA from regular extraction procedure is absorbed by a small amount of glass powder and the final precipitation of glass powder is used directly as a template for PCR. Taking six plant taxa, including the herbarium specimens of Lythraceae collected from Namibia in 1957 and the silicon-dried leaf tissue from mangrove plants (Rhizo-phoraceae and Combretaceae) rich in by-products as examples, the PCR products, including nrDNA ITS regions and cpDNA rbcL gene, amplified following the regular and new methods respectively are compared. Our method provides a simple, rapid and economic approach to purify and prepare template DNA for PCR from special plant materials.展开更多
We studied the transport properties of a driven-dissipative photonic network, where multiple photonic cavities are coupled through a nonreciprocal bus with unidirectional transmission. For short-range coupling between...We studied the transport properties of a driven-dissipative photonic network, where multiple photonic cavities are coupled through a nonreciprocal bus with unidirectional transmission. For short-range coupling between the cavities, the occurrence of nonreciprocal amplification can be linked to a topological phase transition of the underlying dynamic Hamiltonian. However, for long-range coupling, we show that the correspondence between the nonreciprocal amplification transition and the topological phase transition breaks down as the transition conditions deviate significantly from each other. We found the exact transition condition for nonreciprocal amplification, supported by analytical calculation and numerical simulation. We also investigated the stability, the crossover from short-to long-range coupling, and the bandwidth of the nonreciprocal amplification. Our work has potential applications in signal transmission and amplification, and also paves the way to study other topological and non-Hermitian systems with long-range coupling and nontrivial boundary effects.展开更多
AIM: To summarize clinical features of probable severe acute respiratory syndrome (SARS) in Beijing.METHODS: Retrospective cases involving 801 patients admitted to hospitals in Beijing between March and June 2003, wit...AIM: To summarize clinical features of probable severe acute respiratory syndrome (SARS) in Beijing.METHODS: Retrospective cases involving 801 patients admitted to hospitals in Beijing between March and June 2003, with a diagnosis of probable SARS, moderate type.The series of clinical manifestation, laboratory and radiograph data obtained from 801 cases were analyzed. RESULTS: One to three days after the onset of SARS, the major clinical symptoms were fever (in 88.14% of patients), fatigue, headache, myalgia, arthralgia (25-36%), etc. The counts of WBC (in 22.56% of patients) lymphocyte (70.25%)and CD3, CD4, CD8 positive T cells (70%) decreased. From 4-7 d, the unspecific symptoms became weak; however, the rates of low respiratory tract symptoms, such as cough (24.18%), sputum production (14.26%), chest distress (21.04%) and shortness of breath (9.23%) increased, so did the abnormal rates on chest radiograph or CT. The low counts of WBC, lymphocyte and CD3, CD4, CD8 positiveT cells touched bottom. From 8 to 16 d, the patients presented progressive cough (29.96%), sputum production (13.09%), chest distress (29.96%) and shortness of breath (35.34%). All patients had infiltrates on chest radiograph or CT, some even with multi-infiltrates. Two weeks later, patients' respiratory symptoms started to alleviate, the infiltrates on the lung began to absorb gradually, the counts of WBC, lymphocyte and CD3, CD4, CD8 positive T cells were restored to normality.CONCLUSION: The data reported here provide evidence that the course of SARS could be divided into four stages, namely the initial stage, progressive stage, fastigium and convalescent stage.展开更多
目的探究益气活血通络方对糖尿病视网膜病变(DR)患者血糖及炎症因子水平的影响。方法选取2019年1月至2021年5月潍坊医学院附属医院收治的80例DR患者作为研究对象,随机分为对照组与治疗组,各40例。对照组给予羟苯磺酸钙治疗,治疗组在对...目的探究益气活血通络方对糖尿病视网膜病变(DR)患者血糖及炎症因子水平的影响。方法选取2019年1月至2021年5月潍坊医学院附属医院收治的80例DR患者作为研究对象,随机分为对照组与治疗组,各40例。对照组给予羟苯磺酸钙治疗,治疗组在对照组治疗基础上给予益气活血通络方治疗。比较两组临床疗效、治疗前后血糖[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbAlc)]水平及炎症因子[血清C肽、肿瘤坏死因子(TNF-α)、白细胞介素-1β(IL-1β)]水平。结果治疗组治疗总有效率为92.50%,高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗前,两组血清FBG、2 h PBG、HbAlc水平比较差异无统计学意义;治疗后,两组血清FBG、2 h PBG、HbAlc水平均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清C肽、血清TNF-α、IL-1β水平比较差异无统计学意义;治疗后,两组血清C肽水平均高于治疗前,血清TNF-α、IL-1β水平均低于治疗前,且治疗组血清C肽水平高于对照组,血清TNF-α、IL-1β水平均低于对照组,差异有统计学意义(P<0.05)。结论益气活血通络方可有效降低DR患者血糖和炎症因子水平,改善血管微循环和临床症状,疗效显著。展开更多
Surface tension of molten Ni and Ni-Co (5 and 10 mass fraction) alloys was measured at the temperature range of 1773-1873 K using an improved sessile drop method with an alumina substrate in an Ar+3%H2 atmosphere. The...Surface tension of molten Ni and Ni-Co (5 and 10 mass fraction) alloys was measured at the temperature range of 1773-1873 K using an improved sessile drop method with an alumina substrate in an Ar+3%H2 atmosphere. The error of the data obtained was analyzed. The surface tension of molten Ni and Ni-Co (5 and 10 mass fraction) alloys decreases with increasing temperature. The influence of Co on the surface tension of Ni-Co alloys is little in the studied Co concentration range.展开更多
One of the most exciting perspectives of quantum technology is the realization of quantum internet[1],where information is distributed and shared over many distant sites,connected by fibers or satellite-based repeater...One of the most exciting perspectives of quantum technology is the realization of quantum internet[1],where information is distributed and shared over many distant sites,connected by fibers or satellite-based repeaters,with indestructible encryption promised by the fundamental laws of quantum mechanics(QM).Einstein-Podolsky-Rosen(EPR)steer-ing in multipartite scenarios has been recognized as a reliable resource for the implementation of secure multiuser quantum cryptography and teleportation,even when some users(or their devices)of the network are malicious or untrusted.展开更多
基金supported by the National Key Basic Research Program of China (No. 2013CB934303)the Environmental Protection Program of Jiangsu Province of China (No. 2015011)the Youth Innovation Promotion Association of Chinese Academy of Sciences (No. 2014270)
文摘Organophosphorus pesticides （OPs） are one of the most regular pollutants and frequently detected in the contaminated sites, so developing an efficient method for the treatment of OPs is highly required. The aim of the present study was to compare the effectiveness of persulfate （PS） activation and Fenton reaction in remediating the soil polluted with OPs. The polluted soil used in this study was sampled from an abandoned insecticide factory in Nantong, Jiangsu Province of China, mainly containing chloropyrifos （CP） and 4-bromo-2-chlorophenol （BCP, the raw material of profenofos） with total concentration of about 30 000 mg kg- 1. The results showed that both BCP and CP were efficiently degraded by base activation of PS, and increasing the ratio of NaOH/PS enhanced CP degradation, but slightly decreased BCP degradation. The greatest degradation rates for CP and BCP were 92% and 97%, respectively, with 7.0 tool L-1 NaOH and 0.21 tool L-1 PS and a soil-to-liquid ratio of 1：1. Furthermore, ferrous iron activation of PS also degraded BCP efficiently, but only 60% of CP was degraded under the same reaction conditions. These results indicated that base activation of PS was more feasible than Fe2＋ activation and Fenton reaction in remediating the soil polluted with OPs. The high degradation rate for CP may be linked to the initial hydrolyzation of CP by base to 3,5,6-trichloro-2-pyridinol, which can be further rapidly degraded by free radicals generated from base activation of PS.
基金supported by the National Natural Science Foundation of China(82202078)supported by the Major Project of the National Social Science Foundation of China(23&ZD203)+7 种基金the Open Project of the Key Laboratory of ForensicGenetics of the Ministry of Public Security(2022FGKFKT05)the Center for Archaeological Science of Sichuan University(23SASA01)supported by the 1‧3‧5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC20002)the Sichuan Science and Technology Program(2024NSFSC1518)supported by the National Key Research and Development Program of China(No.2023YFC2605400)the National Natural Science Foundation of China(32288101,32030020)the Shanghai Science and Technology Commission Program(23JS1410100)the Office of Global Partnerships(Key Projects Development Fund).
文摘Central Asia,a crucible of prehistoric and historical Trans-Eurasian interactions,has been pivotal in shaping cultural exchanges,population dynamics,and genetic admixture.Recent insights from ancient DNA studies have shed light on the extensive population turnover within this region,encompassing a spectrum of groups from Paleolithic huntergatherers to Holocene herders and the nomadic pastoralist empires of historical times.The genomic analysis of ancient pathogens across the Eurasian steppe has further deepened our understanding of pathogen origins,clonal expansions,and the intricate processes of host-pathogen coevolution in relation to varying pathogen exposures and their spread.We consolidate the latest findings pertaining to the ancient human and pathogen genomes of Central Asia,elucidating their profound influence on the genomic tapestry of contemporary Central Asians.A notable gap in the current genomic databases for Central Asia is underscored,particularly within the scope of genomics-driven precision medicine.We stress the urgent need for the development of extensive,region-specific genomic resources that hold promise for revealing the genetic blueprints underlying human traits and diseases,refining polygenic scoring models for predictive medicine,and bolstering genomic research endeavors across Central Asia.
文摘The density of Ni-AI alloys in both liquid state and solid-liquid coexistence state was measured with a modified pycnometric method. It was found that the density of Ni-AI alloys decreases with increasing temperature and Al concentration in the alloys. The molar volume of liquid Ni-AI binary alloys increases with the increase of temperature and Al concentration. The partial molar volume of Al in Ni-AI binary alloy was calculated approximately. The molar volume of liquid Ni-AI alloy determined in the present work shows a negative deviation from the ideal linear molar volume.
基金supported by the National Key Research and Development Program of China(82030030)the 1·3·5 Project for Disciplines of Excellence,West China Hospital+1 种基金Sichuan University(ZYJC20002)to H.YuanSichuan Science and Technology Program(2022YFS0211)to K.Wu.
文摘Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and functional genomics tools has enabled the systematic identification of functional noncoding variants. These variants can impact gene expression, regulation, and chromatin conformation, thereby contributing to disease pathogenesis. Understanding the mechanisms that underlie the impact of noncoding variants on genetic diseases is indispensable for the development of precisely targeted therapies and the implementation of personalized medicine strategies. The intricacies of noncoding regions introduce a multitude of challenges and research opportunities. In this review, we introduce a spectrum of noncoding variants involved in genetic diseases, along with research strategies and advanced technologies for their precise identification and in-depth understanding of the complexity of the noncoding genome. We will delve into the research challenges and propose potential solutions for unraveling the genetic basis of rare and complex diseases.
基金supported by the National Natural Science Foundation of China(82171836)the 1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYJC20002).
文摘The application of whole genome sequencing is expanding in clinical diagnostics across various genetic disorders, and the significance of non-coding variants in penetrant diseases is increasingly being demonstrated. Therefore, it is urgent to improve the diagnostic yield by exploring the pathogenic mechanisms of variants in non-coding regions. However, the interpretation of non-coding variants remains a significant challenge, due to the complex functional regulatory mechanisms of non-coding regions and the current limitations of available databases and tools. Hence, we develop the non-coding variant annotation database (NCAD, http://www.ncawdb.net/), encompassing comprehensive insights into 665,679,194 variants, regulatory elements, and element interaction details. Integrating data from 96 sources, spanning both GRCh37 and GRCh38 versions, NCAD v1.0 provides vital information to support the genetic diagnosis of non-coding variants, including allele frequencies of 12 diverse populations, with a particular focus on the population frequency information for 230,235,698 variants in 20,964 Chinese individuals. Moreover, it offers prediction scores for variant functionality, five categories of regulatory elements, and four types of non-coding RNAs. With its rich data and comprehensive coverage, NCAD serves as a valuable platform, empowering researchers and clinicians with profound insights into non-coding regulatory mechanisms while facilitating the interpretation of non-coding variants.
文摘The density of liquid binary Ni-Mo alloys with molybdenum concentration from 0 to 20% (mass fraction) wasmeasured by a modified sessile drop method. It has been found that the density of the liquid Ni-Mo alloys decreaseswith increasing temperature, but increases with the increase of molybdenum concentration in the alloys. The molarvolume of liquid Ni-Mo binary alloys increases with the increase of temperature and molybdenum concentration. Thepartial molar volume of molybdenum in Ni-Mo binary alloy has been approximately calculated as [13.18-2.65×10^(-3)T+(-47.94+3.10×10^(-2)T)×10^(-2)X_(Mo)]×10^(-6)m^3·mol^(-1). The molar volume of Ni-Mo alloy determined inthe present work shows a negative deviation from the ideal linear mixing molar volume.
基金This work was supported by Hunan Provincial Natural Science Foundation.
文摘FeAl/TiC composites were fabricated by hot pressing blended elemental powders. The effects of Ni-doping on thedensification and mechanical properties of the composites were studied. Results show that the density of the composites decreases with the content of TiC increasing, and the addition of Ni significantly improves the densificationprocess by enhancing mass transfer in the bonding phase. The mechanical properties of the composites are closelyrelated with their porosity. Besides increasing the density of the composites, the addition of Ni improves the mechanical properties by other three effects: solution-strengthening the bonding phase, strengthening the FeAI-TiC interfaceand increasing ductile fracture in FeAl phase.
基金supported by the National Natural Science Foundation of China(No.92159106,82073230)the National Youth Top-Level Talent Support Program(“Ten Thousand Talents Scheme”)(12Y4962).
文摘Epidermal growth factor receptor(EGFR)is reportedly overexpressed in most esophageal squamous cell carcinoma(ESCC)patients,but anti-EGFR treatments offer limited survival benefits.Our preclinical data showed the promising antitumor activity of afatinib in EGFR-overexpressing ESCC.This proof-of-concept,phase II trial assessed the efficacy and safety of afatinib in pretreated metastatic ESCC patients(n=41)with EGFR overexpression(NCT03940976).The study met its primary endpoint,with a confirmed objective response rate(ORR)of 39%in 38 efficacy-evaluable patients and a median overall survival of 7.8 months,with a manageable toxicity profile.Transcriptome analysis of pretreatment tumors revealed that neurotrophic receptor tyrosine kinase 2(NTRK2)was negatively associated with afatinib sensitivity and might serve as a predictive biomarker,irrespective of EGFR expression.Notably,knocking down or inhibiting NTRK2 sensitized ESCC cells to afatinib treatment.Our study provides novel findings on the molecular factors underlying afatinib resistance and indicates that afatinib has the potential to become an important treatment for metastatic ESCC patients.
基金supported by the National Natural Science Foundation of China (No. 41671493)the Natural Science Foundation of Jiangsu Province (No. BK20191372)the National Major Project of the Science and Technology Ministry of China (No. 2017ZX07202-004)
文摘Nitrated polycyclic aromatic hydrocarbons(NPAHs)are widespread organic pollutants that possess carcinogenic and mutagenic properties,so they may pose a risk to the environment and human health.In this study,the concentrations of 15 NPAHs and 16 polycyclic aromatic hydrocarbons(PAHs)in 30 surface water samples and 26 sediment samples were measured in 2018 from the Taige Canal,one of the main rivers flowing into Taihu Lake,China.The total NPAH concentrations in water and sediment ranged from 14.7 to 235 ng/L and 22.9 to 96.5 ng/g dw,respectively.9-nitrophenanthrene(nd–76.3 ng/L)was the dominant compound in surface water,while 2+3-nitrofluoranthene(1.73–18.1 ng/g dw)dominated in sediment.Among PAHs,concentration ranging from 1,097 to 2,981 ng/L and 1,089 to 4,489 ng/g dw in surface water and sediment,respectively.There was a strong positive correlation between the log octanol-water partition coefficient(Kow)and log sediment-water partition coefficient due to hydrophobic interaction.The fugacity fraction value increased with the decrease of log Kow,and chrysene was transferred from water into sediment.The residual NPAHs in surface water and sediment of the Taige Canal have partial correlation.Diesel engine and coal combustion emissions were probably the principal sources of NPAHs in surface water and sediment.The results of ecological risk assessment showed that some NPAHs inwater(e.g,1-nitropyrene and 6-nitrochrysene)and sediment(e.g.,2-nitrobiphenyl,5-nitroacenaphthene,9-nitrophenanthrene and 2+3-nitrofluoranthene)had moderate ecological risks,which should be of concern.
文摘Density of molten Ni and Ni-W alloys was measured in the temperature range of 1773-1873 K with a sessile drop method. The density of molten Ni and Ni-W alloys trends to decrease with increasing temperature. The density and molar volume of the alloys trend to increase with increasing W concentration in the alloys. The calculation result shows an ideal mixing of Ni-W alloys.
文摘The molecular phylogenetic trees of 10 species representing 6 genera of the family Rhizophoraceae have been constructed using the sequences of chloroplast genes ma/K and rbcL as well as the ITS regions of nuclear ribosomal DMA. Relative-rate tests between lineages in these phylogenetic trees have been performed. On the basis of the results of the relative-rate tests and related molecular evolutionary rate data, the divergence times between the lineages are estimated as follows: ( i) the first divergence time in these genera is 132.25 million years ago (mya); (ii) the average divergence time between two tribes, i.e. inland Legnotideae (except Carallia brachiata) and mangrove Rhizophoreae, is 64.13 mya; and (iii) the average divergence time between two inland species, C. garciniaefolia and C. pectinifolia, is 19.92 mya.
基金This work was supported by the Chinese National Science Funds for Distinguished Young Scholar (Grant No. 39825104)the National Natural Science Foundation of China (Grant Nos. 39970057 and 30170071) the Natural Science Foundation of Guangdong Provinc
文摘A simple method for preparation of template DNA suitable for PCR amplification from herbarium samples and plant tissues rich in byproducts, e.g. polysaccha-rides, tannins, polyphenolic, and terpenoids compounds, is described. The total DNA from regular extraction procedure is absorbed by a small amount of glass powder and the final precipitation of glass powder is used directly as a template for PCR. Taking six plant taxa, including the herbarium specimens of Lythraceae collected from Namibia in 1957 and the silicon-dried leaf tissue from mangrove plants (Rhizo-phoraceae and Combretaceae) rich in by-products as examples, the PCR products, including nrDNA ITS regions and cpDNA rbcL gene, amplified following the regular and new methods respectively are compared. Our method provides a simple, rapid and economic approach to purify and prepare template DNA for PCR from special plant materials.
基金National Natural Science Foundation of China(11974031, 11975026, 12074428, 12125402, 12147148)Beijing Municipal Natural Science Foundation (Z180013,Z190005)+3 种基金National Key Research and Development Program of China (2018YFA0306501)Key R&D Program of Guangdong Province (2018B030329001)Innovation Program for Quantum Science and Technology (2021ZD0301702)China Postdoctoral Science Foundation (2020M680186)。
文摘We studied the transport properties of a driven-dissipative photonic network, where multiple photonic cavities are coupled through a nonreciprocal bus with unidirectional transmission. For short-range coupling between the cavities, the occurrence of nonreciprocal amplification can be linked to a topological phase transition of the underlying dynamic Hamiltonian. However, for long-range coupling, we show that the correspondence between the nonreciprocal amplification transition and the topological phase transition breaks down as the transition conditions deviate significantly from each other. We found the exact transition condition for nonreciprocal amplification, supported by analytical calculation and numerical simulation. We also investigated the stability, the crossover from short-to long-range coupling, and the bandwidth of the nonreciprocal amplification. Our work has potential applications in signal transmission and amplification, and also paves the way to study other topological and non-Hermitian systems with long-range coupling and nontrivial boundary effects.
基金Supported by the National High Technology Research and Development Program of China (863 Program), No. 2003AA208107 Correspondence to: Xiao-Yuan Xu
文摘AIM: To summarize clinical features of probable severe acute respiratory syndrome (SARS) in Beijing.METHODS: Retrospective cases involving 801 patients admitted to hospitals in Beijing between March and June 2003, with a diagnosis of probable SARS, moderate type.The series of clinical manifestation, laboratory and radiograph data obtained from 801 cases were analyzed. RESULTS: One to three days after the onset of SARS, the major clinical symptoms were fever (in 88.14% of patients), fatigue, headache, myalgia, arthralgia (25-36%), etc. The counts of WBC (in 22.56% of patients) lymphocyte (70.25%)and CD3, CD4, CD8 positive T cells (70%) decreased. From 4-7 d, the unspecific symptoms became weak; however, the rates of low respiratory tract symptoms, such as cough (24.18%), sputum production (14.26%), chest distress (21.04%) and shortness of breath (9.23%) increased, so did the abnormal rates on chest radiograph or CT. The low counts of WBC, lymphocyte and CD3, CD4, CD8 positiveT cells touched bottom. From 8 to 16 d, the patients presented progressive cough (29.96%), sputum production (13.09%), chest distress (29.96%) and shortness of breath (35.34%). All patients had infiltrates on chest radiograph or CT, some even with multi-infiltrates. Two weeks later, patients' respiratory symptoms started to alleviate, the infiltrates on the lung began to absorb gradually, the counts of WBC, lymphocyte and CD3, CD4, CD8 positive T cells were restored to normality.CONCLUSION: The data reported here provide evidence that the course of SARS could be divided into four stages, namely the initial stage, progressive stage, fastigium and convalescent stage.
文摘目的探究益气活血通络方对糖尿病视网膜病变(DR)患者血糖及炎症因子水平的影响。方法选取2019年1月至2021年5月潍坊医学院附属医院收治的80例DR患者作为研究对象,随机分为对照组与治疗组,各40例。对照组给予羟苯磺酸钙治疗,治疗组在对照组治疗基础上给予益气活血通络方治疗。比较两组临床疗效、治疗前后血糖[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbAlc)]水平及炎症因子[血清C肽、肿瘤坏死因子(TNF-α)、白细胞介素-1β(IL-1β)]水平。结果治疗组治疗总有效率为92.50%,高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗前,两组血清FBG、2 h PBG、HbAlc水平比较差异无统计学意义;治疗后,两组血清FBG、2 h PBG、HbAlc水平均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清C肽、血清TNF-α、IL-1β水平比较差异无统计学意义;治疗后,两组血清C肽水平均高于治疗前,血清TNF-α、IL-1β水平均低于治疗前,且治疗组血清C肽水平高于对照组,血清TNF-α、IL-1β水平均低于对照组,差异有统计学意义(P<0.05)。结论益气活血通络方可有效降低DR患者血糖和炎症因子水平,改善血管微循环和临床症状,疗效显著。
文摘Surface tension of molten Ni and Ni-Co (5 and 10 mass fraction) alloys was measured at the temperature range of 1773-1873 K using an improved sessile drop method with an alumina substrate in an Ar+3%H2 atmosphere. The error of the data obtained was analyzed. The surface tension of molten Ni and Ni-Co (5 and 10 mass fraction) alloys decreases with increasing temperature. The influence of Co on the surface tension of Ni-Co alloys is little in the studied Co concentration range.
基金This work was supported by the National Natural Science Founda-tion of China(Grants No.11622428,No.61675007,and No.11975026,No.12004011)the National Key R&D Program of China(Grants No.2016YFA0301302,No.2018YFB1107205)+1 种基金the Key R&D Program of Guangzhou Province(Grant No.2018B030329001)the Beijing Nat-ural Science Foundation(Grant No.Z190005).
文摘One of the most exciting perspectives of quantum technology is the realization of quantum internet[1],where information is distributed and shared over many distant sites,connected by fibers or satellite-based repeaters,with indestructible encryption promised by the fundamental laws of quantum mechanics(QM).Einstein-Podolsky-Rosen(EPR)steer-ing in multipartite scenarios has been recognized as a reliable resource for the implementation of secure multiuser quantum cryptography and teleportation,even when some users(or their devices)of the network are malicious or untrusted.
