目的本研究旨在分析并比较心肌肌钙蛋白I(cardiac troponin I,cTnI)升高及STAF评分(Score for the Targeting of Atrial Fibrillation)对心源性脑梗死诊断的预测价值。方法本研究纳入223例急性缺血性脑卒中患者,心源性脑梗死38例,非心...目的本研究旨在分析并比较心肌肌钙蛋白I(cardiac troponin I,cTnI)升高及STAF评分(Score for the Targeting of Atrial Fibrillation)对心源性脑梗死诊断的预测价值。方法本研究纳入223例急性缺血性脑卒中患者,心源性脑梗死38例,非心源性脑梗死185例。收集患者详细的临床资料后,检测血清cTnI的浓度,计算STAF评分。比较两组临床基线资料,采用ROC曲线确定cTnI和STAF评分对心源性脑梗死诊断的界值,并对比分析其预测价值。结果心源性脑梗死组患者相比于非心源性脑梗死组,年龄更大,心房颤动、缺血性心脏病史更多,NIHSS评分、cTnI 值以及STAF评分明显更高(P<0.05)。STAF的ROC曲线下面积为0.954,其95%CI为0.924~0.985。cTnI值的ROC曲线下面积为0.852,其95%CI为0.788~0.916。STAF评分截点为4分,此时灵敏度为92.1%,特异度为89.2%。cTnI值截点为0.0085 ng/mL,此时灵敏度为73.7%,特异度为84.9%。结论本研究中STAF评分和cTnI 值均对心源性脑梗死有良好的预测价值,且STAF评分对心源性脑梗死诊断的预测价值高于cTnI。血清cTnI 值和STAF评分对急性缺血性脑卒中患者的病因分型具有一定的临床运用价值。展开更多
Utilizing the periodically structured metal-organic framework （MOF） as the reaction vessel is a promising technique to achieve the aligned polymer molecular chains, where the diffusion procedure of the polymer monom...Utilizing the periodically structured metal-organic framework （MOF） as the reaction vessel is a promising technique to achieve the aligned polymer molecular chains, where the diffusion procedure of the polymer monomer inside MOF is one of the key mechanisms. To investigate the diffusion mechanism of fluorinated polymer monomers in MOFs, in this paper the molecular dynamics simulations combined with the density functional theory and the Monte Carlo method are used and the all-atom models of TFMA （trifluoroethyl methacrylate） monomer and two types of MOFs,[Zn2（BDC）2（TED）]n and[Zn2（BPDC）2（TED）]n, are established. The diffusion behaviors of TFMA monomer in these two MOFs are simulated and the main influencing factors are analyzed. The obtained results are as follows. First, the electrostatic interactions between TFMA monomers and MOFs cause the monomers to concentrate in the MOF channel, which slows down the monomer diffusion. Second, the anisotropic shape of the one-dimensional MOF channel leads to different diffusion speeds of monomers in different directions. Third, MOF with a larger pore diameter due to a longer organic ligand,[Zn2（BPDC）2（TED）]n in this paper, facilitates the diffusion of monomers in the MOF channel. Finally, as the number of monomers increases, the self-diffusion coefficient is reduced by the steric effect.展开更多
文摘目的本研究旨在分析并比较心肌肌钙蛋白I(cardiac troponin I,cTnI)升高及STAF评分(Score for the Targeting of Atrial Fibrillation)对心源性脑梗死诊断的预测价值。方法本研究纳入223例急性缺血性脑卒中患者,心源性脑梗死38例,非心源性脑梗死185例。收集患者详细的临床资料后,检测血清cTnI的浓度,计算STAF评分。比较两组临床基线资料,采用ROC曲线确定cTnI和STAF评分对心源性脑梗死诊断的界值,并对比分析其预测价值。结果心源性脑梗死组患者相比于非心源性脑梗死组,年龄更大,心房颤动、缺血性心脏病史更多,NIHSS评分、cTnI 值以及STAF评分明显更高(P<0.05)。STAF的ROC曲线下面积为0.954,其95%CI为0.924~0.985。cTnI值的ROC曲线下面积为0.852,其95%CI为0.788~0.916。STAF评分截点为4分,此时灵敏度为92.1%,特异度为89.2%。cTnI值截点为0.0085 ng/mL,此时灵敏度为73.7%,特异度为84.9%。结论本研究中STAF评分和cTnI 值均对心源性脑梗死有良好的预测价值,且STAF评分对心源性脑梗死诊断的预测价值高于cTnI。血清cTnI 值和STAF评分对急性缺血性脑卒中患者的病因分型具有一定的临床运用价值。
基金Project supported by the National Natural Science Foundation of China(Grant No.61575096)
文摘Utilizing the periodically structured metal-organic framework （MOF） as the reaction vessel is a promising technique to achieve the aligned polymer molecular chains, where the diffusion procedure of the polymer monomer inside MOF is one of the key mechanisms. To investigate the diffusion mechanism of fluorinated polymer monomers in MOFs, in this paper the molecular dynamics simulations combined with the density functional theory and the Monte Carlo method are used and the all-atom models of TFMA （trifluoroethyl methacrylate） monomer and two types of MOFs,[Zn2（BDC）2（TED）]n and[Zn2（BPDC）2（TED）]n, are established. The diffusion behaviors of TFMA monomer in these two MOFs are simulated and the main influencing factors are analyzed. The obtained results are as follows. First, the electrostatic interactions between TFMA monomers and MOFs cause the monomers to concentrate in the MOF channel, which slows down the monomer diffusion. Second, the anisotropic shape of the one-dimensional MOF channel leads to different diffusion speeds of monomers in different directions. Third, MOF with a larger pore diameter due to a longer organic ligand,[Zn2（BPDC）2（TED）]n in this paper, facilitates the diffusion of monomers in the MOF channel. Finally, as the number of monomers increases, the self-diffusion coefficient is reduced by the steric effect.
