目的评估高血压患者血浆低密度脂蛋白胆固醇(LDL-C)与肾功能轻度下降的关系,为早期预防高血压并发慢性肾脏病提供参考。方法本研究于2020年6—9月在安庆市农村地区采用多阶段抽样方法随机抽取7个乡镇,共纳入1959例高血压患者,获取调查...目的评估高血压患者血浆低密度脂蛋白胆固醇(LDL-C)与肾功能轻度下降的关系,为早期预防高血压并发慢性肾脏病提供参考。方法本研究于2020年6—9月在安庆市农村地区采用多阶段抽样方法随机抽取7个乡镇,共纳入1959例高血压患者,获取调查对象的一般资料、血浆LDL-C水平等信息。采用logistic回归分析LDL-C与肾功能轻度下降的关系。结果1959例高血压患者年龄为(69.2±7.0)岁,肾功能轻度下降患者1231例(62.8%)。调整性别等相关因素后,高血压患者LDL-C与肾功能轻度下降呈正相关,LDL-C每增加1 mmol/L,肾功能轻度下降发生的风险增加57%(OR=1.570,95%CI:1.359~1.813)。将LDL-C三等分,与最低三分位数(T1,<2.2 mmol/L)的患者比较,中三分位数(T2,2.2~<2.9 mmol/L)和最高三分位数(T3,≥2.9 mmol/L)的患者肾功能轻度下降的风险分别增加1.028倍(OR=2.028,95%CI:1.578~2.605)和2.721倍(OR=3.721,95%CI:2.814~4.920)。舒张压升高与LDL-C水平升高对增加肾功能轻度下降风险具有协同作用(舒张压<90 mm Hg vs.≥90 mm Hg,1 mm Hg=0.133 kPa,P_(交互)=0.006)。结论高血压患者LDL-C与肾功能轻度下降呈正相关关系,尤其在舒张压升高的人群中。提示控制高血压患者LDL-C和血压水平可以降低肾功能轻度下降的风险,减轻肾脏靶器官的早期损害。展开更多
Based on the tight binding model, we investigate the low energy bandstructures, edge states, and optical absorptions for the silicene nanoribbons （SiNRs） with different terminations under an in-plane exchange field ...Based on the tight binding model, we investigate the low energy bandstructures, edge states, and optical absorptions for the silicene nanoribbons （SiNRs） with different terminations under an in-plane exchange field and/or a perpendicular electric field. We find that the zigzag SiNRs are gapped by the exchange field, but they could reenter the metallic state after the application of the electric field. Contrarily, a certain kind of armchair SiNRs remain gapless even if a weak exchange field is present. Furthermore, the combination of the exchange and electric fields could effectively modulate the penetration length and the components of the edge states in the SiNRs. The corresponding optical conductivities for the SiNRs are also calculated, which show remarkable dependence on the edge types of the SiNRs and the two external fields.展开更多
文摘目的评估高血压患者血浆低密度脂蛋白胆固醇(LDL-C)与肾功能轻度下降的关系,为早期预防高血压并发慢性肾脏病提供参考。方法本研究于2020年6—9月在安庆市农村地区采用多阶段抽样方法随机抽取7个乡镇,共纳入1959例高血压患者,获取调查对象的一般资料、血浆LDL-C水平等信息。采用logistic回归分析LDL-C与肾功能轻度下降的关系。结果1959例高血压患者年龄为(69.2±7.0)岁,肾功能轻度下降患者1231例(62.8%)。调整性别等相关因素后,高血压患者LDL-C与肾功能轻度下降呈正相关,LDL-C每增加1 mmol/L,肾功能轻度下降发生的风险增加57%(OR=1.570,95%CI:1.359~1.813)。将LDL-C三等分,与最低三分位数(T1,<2.2 mmol/L)的患者比较,中三分位数(T2,2.2~<2.9 mmol/L)和最高三分位数(T3,≥2.9 mmol/L)的患者肾功能轻度下降的风险分别增加1.028倍(OR=2.028,95%CI:1.578~2.605)和2.721倍(OR=3.721,95%CI:2.814~4.920)。舒张压升高与LDL-C水平升高对增加肾功能轻度下降风险具有协同作用(舒张压<90 mm Hg vs.≥90 mm Hg,1 mm Hg=0.133 kPa,P_(交互)=0.006)。结论高血压患者LDL-C与肾功能轻度下降呈正相关关系,尤其在舒张压升高的人群中。提示控制高血压患者LDL-C和血压水平可以降低肾功能轻度下降的风险,减轻肾脏靶器官的早期损害。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11347127,61404044,and 11347111)
文摘Based on the tight binding model, we investigate the low energy bandstructures, edge states, and optical absorptions for the silicene nanoribbons （SiNRs） with different terminations under an in-plane exchange field and/or a perpendicular electric field. We find that the zigzag SiNRs are gapped by the exchange field, but they could reenter the metallic state after the application of the electric field. Contrarily, a certain kind of armchair SiNRs remain gapless even if a weak exchange field is present. Furthermore, the combination of the exchange and electric fields could effectively modulate the penetration length and the components of the edge states in the SiNRs. The corresponding optical conductivities for the SiNRs are also calculated, which show remarkable dependence on the edge types of the SiNRs and the two external fields.
