摘要
目的了解安徽省岳西县607例中老年高血压患者高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)现状及相关影响因素,为心脑血管疾病防治提供科学依据。方法采用多阶段抽样方法,于2020年6月至9月对安徽省岳西县607例高血压患者进行调查。根据血浆同型半胱氨酸(homocysteine,Hcy)水平将研究对象分为高同型半胱氨酸组(HHcy组)和非高同型半胱氨酸组(non-HHcy组),通过体格检查和问卷调查获得研究对象的血压、吸烟史等信息;通过实验室检测获取研究对象的血浆Hcy、血脂等水平;采用SPSS 16.0统计软件对数据进行处理和分析。结果纳入研究的中老年高血压患者共607例,血浆Hcy均值为(17.41±16.63)μmol/L,non-HHcy组血浆Hcy平均水平为(11.59±2.29)μmol/L,HHcy组血浆Hcy平均水平为(24.39±22.66)μmol/L;276例患HHcy,患病率为45.47%,其中男性179例,患病率为57.01%,女性97例,患病率为33.11%。non-HHcy组与HHcy组在性别、舒张压(diastolic blood pressure,DBP)、收缩压(systolic pressure,SBP)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、总胆红素(total bilirubin,TBil)、肌酐间差异均具有统计学意义(P<0.05)。多因素logistic回归分析显示性别(OR=0.512,95%CI:0.353~0.742),DBP(OR=1.012,95%CI:1.001~1.023),肌酐(OR=1.018,95%CI:1.009~1.027),HDL-C(OR=0.593,95%CI:0.354~0.993)是HHcy的影响因素。结论HHcy患病率男性高于女性。性别、血压、血脂以及肌酐水平是HHcy的影响因素。
Objective:To investigate the status and related influencing factors of hyperhomocysteinemia(HHcy)in 607 middle-aged and elderly patients with hypertension in Yuexi County,Anhui Province,and to provide scientific basis for the prevention and treatment of cardiovascular and cerebrovascular diseases.Methods:607 patients with hypertension in Yuexi County,Anhui Province were investigated by multi-stage sampling method from June to September 2020.The subjects were divided into hyperhomocysteinemia(HHcy group)and non-hyperhomocysteinemia(non-Hcy group)according to plasma homocysteine(Hcy)levels.Blood pressure,smoking history and other information were obtained through physical examination and questionnaire survey.The Hcy and blood lipid levels of the subjects were obtained through laboratory testing and SPSS 16.0 statistical software was used for data processing and statistical analysis.Results:A total of 607 middle-aged and elderly patients with hypertension were included in the study.The mean level of Hcy was(17.41±16.63)μmol/L,and the mean level of Hcy in non-HHcy group was(11.59±2.29)μmol/L.The average level of plasma Hcy in HHcy group was(24.39±22.66)μmol/L.276 patients had HHcy with a prevalence of 45.47%,including 179 males with a prevalence of 57.01%and 97 females with a prevalence of 33.11%.There were statistically significant differences between the non-HHcy group and the HHcy group in gender,diastolic blood pressure(DBP),systolic blood pressure(SBP),high-density lipoprotein cholesterol(HDL-C),total bilirubin(TBil)and creatinine(P<0.05).Multivariate logistic regression analysis showed gender(OR=0.512,95%CI:0.353~0.742),DBP(OR=1.012,95%CI:1.001~1.023),creatinine(OR=1.018,95%CI:1.009~1.027)and HDL-C(OR=0.593,95%CI:0.354~0.993)were the influencing factors of HHcy.Conclusion:The prevalence of HHcy is higher in males than in females.Gender,blood pressure,blood lipid and creatinine levels are risk factors for HHcy.
作者
吴谦
章如山
邹剑飞
王瑞
张旭
徐亚萍
陈浩
唐根富
WU Qian;ZHANG Rushan;ZOU Jianfei;WANG Rui;ZHANG Xu;XU Yaping;CHEN Hao;TANG Genfu(School of Health Management,Anhui Medical University,Hefei 230032,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
2022年第5期384-387,共4页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
基金
国家自然科学基金面上项目(81773534)。
