Objective： To observe and compare the effects of mild moxibustion and Chinese medicine on the paw edema and pain threshold in rats with experimental arthritis. Methods： Forty-six male Wistar rats were randomly divid...Objective： To observe and compare the effects of mild moxibustion and Chinese medicine on the paw edema and pain threshold in rats with experimental arthritis. Methods： Forty-six male Wistar rats were randomly divided into 5 groups, a control group （10 rats）, a model group （9 rats）, a Chinese medicine （CM） group （9 rats）, a moxibustion group （9 rats） and a Western medicine （WM） group （9 rats）. Except rats in the control group, rats in the other four groups were established to be arthritis model by cold stimulation and Freund＇s adjuvant. After modeling, rats in the control group and the model group were not treated. The remaining three groups were respectively treated with traditional Chinese medicine, moxibustion and Western medicine. Then the changes in the rat paw swelling and pain threshold were observed. Results： The paws of rats＇ swelled significantly after injection of adjuvant. After 7 d of treatment, the rats＇ paws of CM group were still markedly swollen, and compared with the CM group, the swelling of the paws in the WM group and the moxibustion group were statistically significant （P〈0.05）. The rats＇ mechanical pain threshold of the WM group, CM group and the moxibustion group were significantly higher than that of the model group with statistical significance （all P〈0.05）. In CM group, it was higher than in the WM group with statistical significance （P〈0.05）. That in moxibustion group was higher than that in the WM group without significance between the groups （P〉0.05）. Latent period of rat＇s paw withdrawal threshold of the thermal pain in western medicine group was significantly longer than that in the model group with statistically significant （P〈0.05）. But latent period of rat＇s paw withdrawal threshold of the thermal pain in the CM group and the moxibustion group extended without statistical significance （P〉0.05）. Conclusion： The mechanical pain threshold of rats with experimental arthritis can be significantly impr展开更多
基金supported by Science and Technology Innovation Plan for Undergraduate of Zhejiang Province (2010R410001)
文摘Objective： To observe and compare the effects of mild moxibustion and Chinese medicine on the paw edema and pain threshold in rats with experimental arthritis. Methods： Forty-six male Wistar rats were randomly divided into 5 groups, a control group （10 rats）, a model group （9 rats）, a Chinese medicine （CM） group （9 rats）, a moxibustion group （9 rats） and a Western medicine （WM） group （9 rats）. Except rats in the control group, rats in the other four groups were established to be arthritis model by cold stimulation and Freund＇s adjuvant. After modeling, rats in the control group and the model group were not treated. The remaining three groups were respectively treated with traditional Chinese medicine, moxibustion and Western medicine. Then the changes in the rat paw swelling and pain threshold were observed. Results： The paws of rats＇ swelled significantly after injection of adjuvant. After 7 d of treatment, the rats＇ paws of CM group were still markedly swollen, and compared with the CM group, the swelling of the paws in the WM group and the moxibustion group were statistically significant （P〈0.05）. The rats＇ mechanical pain threshold of the WM group, CM group and the moxibustion group were significantly higher than that of the model group with statistical significance （all P〈0.05）. In CM group, it was higher than in the WM group with statistical significance （P〈0.05）. That in moxibustion group was higher than that in the WM group without significance between the groups （P〉0.05）. Latent period of rat＇s paw withdrawal threshold of the thermal pain in western medicine group was significantly longer than that in the model group with statistically significant （P〈0.05）. But latent period of rat＇s paw withdrawal threshold of the thermal pain in the CM group and the moxibustion group extended without statistical significance （P〉0.05）. Conclusion： The mechanical pain threshold of rats with experimental arthritis can be significantly impr
