目的系统评价幽门螺杆菌(H.pylori)感染与阿尔茨海默病(AD)发生的相关性。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方数据库、维普数据库、中国生物医学文献服务系统数据库中关于H.pylori感染与A...目的系统评价幽门螺杆菌(H.pylori)感染与阿尔茨海默病(AD)发生的相关性。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方数据库、维普数据库、中国生物医学文献服务系统数据库中关于H.pylori感染与AD之间关联的病例对照研究和队列研究,检索时限为2000年1月至2022年11月。2名研究者对文献进行筛选、提取资料和质量评价。采用RevMan 5.3软件进行Meta分析。结果共纳入15项研究,包括9项病例对照研究(n=1404),6项队列研究(n=7893)。Meta分析结果显示,AD组的H.pylori感染率高于对照组(OR=1.58,95%CI:1.21~2.06,P<0.05),血清中的H.pylori IgG抗体含量高于对照组(MD=6.14,95%CI:2.99~9.29,P<0.01),简易精神状态检查(MMSE)评分低于对照组(MD=-9.89,95%CI:-14.04~-5.74,P<0.01);H.pylori阳性组的AD发生率高于H.pylori阴性组(RR=1.33,95%CI:1.11~1.59,P<0.01),差异均有统计学意义。结论当前有限的证据表明,AD与H.pylori感染之间有着密切的关联。在AD的发病进展及预后中,H.pylori都起着很重要的作用。展开更多
Objective:To explore the clinical therapeutic effect and the impacts of acupuncture on cerebral blood flow and serum S100β and alkaline phosphatase(ALP) in the patients with post-stroke mild cognitive impairment in c...Objective:To explore the clinical therapeutic effect and the impacts of acupuncture on cerebral blood flow and serum S100β and alkaline phosphatase(ALP) in the patients with post-stroke mild cognitive impairment in convalescence stage.Methods:A total of 66 cases were randomized into a control group(33 cases) and an observation group(33 cases).The conventional treatment was applied in the control group.On the base of the treatment of the control group,acupuncture was added at Shéntíng(神庭GV24),Bǎihuì(百会GV20),Dàzhuī(大椎GV14),Mìngmén(命门GV4),Shènshū(肾俞BL23),Shénmén(神门HT7) and Xuánzhōng(悬钟GB39) in the observation group.Before and after treatment,separately,Montreal cognitive assessment(MoCA),mini-mental state examination(MMSE) and modified Barthel index(MBI) were assessed in the patients,peak systolic velocity(PSV) and resistance index(RI) and the levels of serum S100β and ALP were measured.At the end of treatment,the clinical therapeutic effect was evaluated in patients of the both groups.Results:After treatment,the scores of MoCA,MMSE and MBI in the observation group were all higher than those in the control group.PSV in the observation group was higher than the control group,while RI,S100β and ALP were lower than those in the control group,indicating the statistical differences(all P <0.05).The total effective rate was 93.75% in the observation group,higher than 67.74% in the control group,showing statistical difference(P <0.05).Conclusion:Acupuncture achieves the definite therapeutic effect on post-stroke mild cognitive impairment in convalescence stage.This therapy improves the cognitive function,the quality of life and cerebral blood flow in the patients and also down-regulates the levels of serum S100β and ALP.Hence,this acupuncture therapy is worthy of clinical promotion.展开更多
文摘Objective:To explore the clinical therapeutic effect and the impacts of acupuncture on cerebral blood flow and serum S100β and alkaline phosphatase(ALP) in the patients with post-stroke mild cognitive impairment in convalescence stage.Methods:A total of 66 cases were randomized into a control group(33 cases) and an observation group(33 cases).The conventional treatment was applied in the control group.On the base of the treatment of the control group,acupuncture was added at Shéntíng(神庭GV24),Bǎihuì(百会GV20),Dàzhuī(大椎GV14),Mìngmén(命门GV4),Shènshū(肾俞BL23),Shénmén(神门HT7) and Xuánzhōng(悬钟GB39) in the observation group.Before and after treatment,separately,Montreal cognitive assessment(MoCA),mini-mental state examination(MMSE) and modified Barthel index(MBI) were assessed in the patients,peak systolic velocity(PSV) and resistance index(RI) and the levels of serum S100β and ALP were measured.At the end of treatment,the clinical therapeutic effect was evaluated in patients of the both groups.Results:After treatment,the scores of MoCA,MMSE and MBI in the observation group were all higher than those in the control group.PSV in the observation group was higher than the control group,while RI,S100β and ALP were lower than those in the control group,indicating the statistical differences(all P <0.05).The total effective rate was 93.75% in the observation group,higher than 67.74% in the control group,showing statistical difference(P <0.05).Conclusion:Acupuncture achieves the definite therapeutic effect on post-stroke mild cognitive impairment in convalescence stage.This therapy improves the cognitive function,the quality of life and cerebral blood flow in the patients and also down-regulates the levels of serum S100β and ALP.Hence,this acupuncture therapy is worthy of clinical promotion.
