摘要
目的 比较中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对急性脑梗死患者预后的预测价值。方法 回顾性选取2019年2月至2022年2月新疆医科大学第一附属医院收治的急性脑梗死患者100例,依据预后情况分为预后良好组(n=60)、预后不良组(n=40)两组。单因素分析、多因素Logistic回归分析急性脑梗死患者预后影响因素,分析急性脑梗死患者溶栓治疗后NIHSS评分、mRS评分与中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)的相关性,统计分析两组不同NLR、PLR患者的病死情况。结果 预后良好组的NIHSS评分≥5分、高血压患者比率明显低于预后不良组,发病至溶栓时间明显短于预后不良组,纤维蛋白原、C反应蛋白、中性粒细胞计数、血小板计数、淋巴细胞计数、NRL、PLR水平均明显低于预后不良组,差异均有统计学意义(P<0.05)。急性脑梗死患者溶栓治疗后NIHSS评分与NLR、PLR均呈显著的正相关(r=0.682、0.654,P<0.05),mRS评分与PLR、PLR均呈显著的负相关(r=-0.511、-0.490,P<0.05)。预后良好组患者的病死率(8.33%)明显低于预后不良组(25.00%),差异有统计学意义(P<0.05)。两组NLR>2.83患者的病死率均明显高于NLR≤2.83患者,PLR>130.50患者的病死率均明显高于PLR≤130.50患者,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,急性脑梗死患者预后的影响因素包括NIHSS评分、发病至溶栓时间、NLR、PLR(P<0.05)。结论 急性脑梗死患者预后预测中,中性粒细胞与淋巴细胞比值的临床价值高于血小板与淋巴细胞比值。
Objective To compare the predictive value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction in The First Affiliated Hospital of Xinjiang Medical University from February 2019 to February 2022 were retrospectively selected and divided into two groups according to prognosis: good prognosis group(n=60) and poor prognosis group(n=40). Univariate analysis and multivariate Logistic regression were used to analyze the prognostic factors of patients with acute cerebral infarction, analyze the correlation between NIHSS score, mRS score and Neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR) after thrombolytic therapy in patients with acute cerebral infarction, and statistically analyze the death of patients with different NLR and PLR in the two groups. Results The proportion of NIHSS score ≥5 points, the proportion of hypertensive patients in the good prognosis group was significantly lower than that in the poor prognosis group, the time from onset to thrombolysis was significantly shorter than that in the poor prognosis group, the levels of fibrinogen, C-reactive protein, neutrophil count, platelet count, Lymphocyte count, NRL and PLR were significantly lower than those in the poor prognosis group, and the differences were statistically significant(P<0.05). After thrombolytic therapy, NIHSS score was significantly positively correlated with NLR and PLR(r=0.682, 0.654, P<0.05), while mRS score was significantly negatively correlated with PLR and PLR(r=-0.511,-0.490, P<0.05). The mortality of patients in the good prognosis group was 8.33%, which was lower than that in the poor prognosis group(25.00%), the difference was statistically significant(P<0.05). The mortality of patients with NLR>2.83 in both groups was higher than those with NLR≤2.83, the mortality of patients with PLR>130.50 was higher than those with PLR≤130.50, and the differences were statistically significant(P<
作者
阿加尔·木合大
玛依拉·吐尔逊
罗东辉
AGAR Mu-he-da;Mayla Tur-son;LUO Dong-hui(Department of Neurology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang 830054,China)
出处
《临床和实验医学杂志》
2023年第1期12-15,共4页
Journal of Clinical and Experimental Medicine
基金
国家自然科学基金项目(编号:81860223)。
