Objective： To observe the clinical effects of moxibustion at abdominal acupoints for slow transit constipation（STC） due to yang deficiency of the spleen and kidney. Methods： A total of 52 cases with slow transit c...Objective： To observe the clinical effects of moxibustion at abdominal acupoints for slow transit constipation（STC） due to yang deficiency of the spleen and kidney. Methods： A total of 52 cases with slow transit constipation in conformity with the inclusion criteria were selected and divided into a control group and an observation group according to their visit order and random digital table, 26 cases in each group. Patients in the control group received routine nursing guide. Besides the same routine nursing guide, patients in the observation group received moxibustion at the abdominal acupoints, once every day. The course of the treatment was 4 weeks in the two groups, and the 3-month follow-up was given after the course was finished, for comparing the clinical symptoms, results of colon transit tests, scores of depression/anxiety scale and nursing satisfaction. Results： The total effective rate was 92.3% in the observation group and 69.2% in the control group, with a significant difference between the two groups. After the treatment and during the follow-up checks, the scores of Chinese medical symptoms in the two groups were remarkably decreased than those before the treatment（all P〈0.01）; the scores of the observation group were obviously lower than those in the control group（all P〈0.01）. The discharge rates of the markers in the two groups were remarkably increased than those at the same time period before the treatment; moreover, the discharge rates of the markers at various time periods were remarkably better in the observation group than those in the control group（P〈0.01）. SDS and SAS scores were remarkably decreased after the treatment in the two groups（P〈0.01）. In comparison of SDS score between the two groups after the treatment, the difference was statistically significant（P〈0.01）. In comparison of SAS score between the two groups after the treatment, the difference was statistically significant（P〈0.05）. The nursing satisfaction was 96.2% in the observati展开更多
目的观察解毒化瘀汤对湿热蕴结型活动期溃疡性结肠炎临床疗效及对Th17/Treg细胞及其相关细胞因子的影响。方法选取符合诊断和纳入标准的溃疡性结肠炎患者48例,按照随机数字表法分为对照组和治疗组各24例。其中对照组给予美沙拉嗪肠溶片...目的观察解毒化瘀汤对湿热蕴结型活动期溃疡性结肠炎临床疗效及对Th17/Treg细胞及其相关细胞因子的影响。方法选取符合诊断和纳入标准的溃疡性结肠炎患者48例,按照随机数字表法分为对照组和治疗组各24例。其中对照组给予美沙拉嗪肠溶片口服,治疗组在对照组的基础上给予解毒化瘀汤口服。两组疗程均为12周,分别观察两组患者临床疗效,ELISA法检测白细胞介素-17(IL-17)、白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)水平,Real-Time PCR法检测Th17/Treg细胞的核转录因子RORγt/Foxp3m RNA的表达。结果治疗组总有效率为91.67%,明显优于对照组(P<0.05);两组治疗后IL-17较治疗前均明显降低(P<0.01),两组治疗后IL-10、TGF-β较治疗前均明显升高(P<0.01),治疗后治疗组明显优于对照组(P<0.01);两组治疗后RORγt m RNA、RORγt/Foxp3比值较治疗前均明显降低(P<0.01),两组治疗后Foxp3 m RNA较治疗前均明显升高(P<0.01),治疗后治疗组明显优于对照组(P<0.05或P<0.01)。结论解毒化瘀汤能够明显改善湿热蕴结型活动期溃疡性结肠炎患者临床症状,降低IL-17,增加IL-10、TGF-β水平,调控RORγt、Foxp3 m RNA的表达,促进Th17/Treg细胞平衡,减少复发率,疗效显著。展开更多
基金supported by Program for Science and Technology Development of Heilongjiang Science Technology Bureau,No.GC12C110~~
文摘Objective： To observe the clinical effects of moxibustion at abdominal acupoints for slow transit constipation（STC） due to yang deficiency of the spleen and kidney. Methods： A total of 52 cases with slow transit constipation in conformity with the inclusion criteria were selected and divided into a control group and an observation group according to their visit order and random digital table, 26 cases in each group. Patients in the control group received routine nursing guide. Besides the same routine nursing guide, patients in the observation group received moxibustion at the abdominal acupoints, once every day. The course of the treatment was 4 weeks in the two groups, and the 3-month follow-up was given after the course was finished, for comparing the clinical symptoms, results of colon transit tests, scores of depression/anxiety scale and nursing satisfaction. Results： The total effective rate was 92.3% in the observation group and 69.2% in the control group, with a significant difference between the two groups. After the treatment and during the follow-up checks, the scores of Chinese medical symptoms in the two groups were remarkably decreased than those before the treatment（all P〈0.01）; the scores of the observation group were obviously lower than those in the control group（all P〈0.01）. The discharge rates of the markers in the two groups were remarkably increased than those at the same time period before the treatment; moreover, the discharge rates of the markers at various time periods were remarkably better in the observation group than those in the control group（P〈0.01）. SDS and SAS scores were remarkably decreased after the treatment in the two groups（P〈0.01）. In comparison of SDS score between the two groups after the treatment, the difference was statistically significant（P〈0.01）. In comparison of SAS score between the two groups after the treatment, the difference was statistically significant（P〈0.05）. The nursing satisfaction was 96.2% in the observati
文摘目的观察解毒化瘀汤对湿热蕴结型活动期溃疡性结肠炎临床疗效及对Th17/Treg细胞及其相关细胞因子的影响。方法选取符合诊断和纳入标准的溃疡性结肠炎患者48例,按照随机数字表法分为对照组和治疗组各24例。其中对照组给予美沙拉嗪肠溶片口服,治疗组在对照组的基础上给予解毒化瘀汤口服。两组疗程均为12周,分别观察两组患者临床疗效,ELISA法检测白细胞介素-17(IL-17)、白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)水平,Real-Time PCR法检测Th17/Treg细胞的核转录因子RORγt/Foxp3m RNA的表达。结果治疗组总有效率为91.67%,明显优于对照组(P<0.05);两组治疗后IL-17较治疗前均明显降低(P<0.01),两组治疗后IL-10、TGF-β较治疗前均明显升高(P<0.01),治疗后治疗组明显优于对照组(P<0.01);两组治疗后RORγt m RNA、RORγt/Foxp3比值较治疗前均明显降低(P<0.01),两组治疗后Foxp3 m RNA较治疗前均明显升高(P<0.01),治疗后治疗组明显优于对照组(P<0.05或P<0.01)。结论解毒化瘀汤能够明显改善湿热蕴结型活动期溃疡性结肠炎患者临床症状,降低IL-17,增加IL-10、TGF-β水平,调控RORγt、Foxp3 m RNA的表达,促进Th17/Treg细胞平衡,减少复发率,疗效显著。
