OBJECTIVE: To investigate the pathogenesis, clinical features, radiographic findings and therapeutic outcomes of non-acute intracranial deep venous thrombosis in adults. METHODS: Five patients who presented with incre...OBJECTIVE: To investigate the pathogenesis, clinical features, radiographic findings and therapeutic outcomes of non-acute intracranial deep venous thrombosis in adults. METHODS: Five patients who presented with increased intracranial pressure were examined with computed tomography, magnetic resonance and angiography, diagnosed as having non-acute intracranial deep venous thrombosis, and treated with thrombolytic therapy. They were reviewed retrospectively. RESULTS: There were 3 men and 2 women, aged from 22 to 49 years. Symptom duration ranged from 1 month to 7 months, and 4 of the 5 patients were associated with venous sinus thrombosis. Two patients developed cold and fever before the onset of disease, and 3 patients had no evident predisposing factors. After the infusion of thrombolytic and systemic anti-coagulant therapy, the neurological symptoms and signs of the patients were alleviated. CONCLUSIONS: Digital subtraction angiography (DSA) is more sensitive and accurate than MRI on diagnosing intracranial deep venous thrombosis. It may play an important role in the assessment of the treatment of intracranial deep venous thrombosis. Thrombolysis and anticoagulation of intracranial deep venous thrombosis appears to be a safe and efficacious treatment not only in the acute stage but also in the non-acute stage.展开更多
文摘【目的】探讨唑来膦酸和帕米膦酸治疗恶性肿瘤骨转移并恶性高钙血症的有效性和耐受性。【方法】采用开放、对照研究方法,病理或细胞学证实的恶性肿瘤患者经ECT和X线或CT或MRI证明骨转移且校正血清钙值(CSC)≥12.0 mg/dl,接受唑来膦酸4 mg加入生理盐水注射液100 ml中静脉滴注15 min或帕米膦酸60 mg加入生理盐水注射液500 ml中静脉滴注至少4 h,定期追踪观察患者的疼痛(NRS)、CSC水平并对临床、血尿常规、肝肾功能进行监测。【结果】20例肿瘤骨转移并高钙血症患者,唑来膦酸治疗12例,帕米膦酸8例,经治疗后疼痛明显缓解(唑来膦酸:5.92 vs 3.25,P<0.01;帕米膦酸:6.13 vs 4.38,P<0.01);血钙浓度较治疗前明显下降(唑来膦酸:12.86 vs 10.28 mg/dl,P<0.01;帕米膦酸:13.19 vs 10.36 mg/dl,P<0.01);CSC的有效率均为90%左右。1例帕米膦酸治疗后3 h出现低热,未作特殊处理好转;血尿常规、肝肾功能无明显异常加重的趋势。【结论】唑来膦酸和帕米膦酸对恶性高钙血症有明显疗效,耐受性良好。
文摘OBJECTIVE: To investigate the pathogenesis, clinical features, radiographic findings and therapeutic outcomes of non-acute intracranial deep venous thrombosis in adults. METHODS: Five patients who presented with increased intracranial pressure were examined with computed tomography, magnetic resonance and angiography, diagnosed as having non-acute intracranial deep venous thrombosis, and treated with thrombolytic therapy. They were reviewed retrospectively. RESULTS: There were 3 men and 2 women, aged from 22 to 49 years. Symptom duration ranged from 1 month to 7 months, and 4 of the 5 patients were associated with venous sinus thrombosis. Two patients developed cold and fever before the onset of disease, and 3 patients had no evident predisposing factors. After the infusion of thrombolytic and systemic anti-coagulant therapy, the neurological symptoms and signs of the patients were alleviated. CONCLUSIONS: Digital subtraction angiography (DSA) is more sensitive and accurate than MRI on diagnosing intracranial deep venous thrombosis. It may play an important role in the assessment of the treatment of intracranial deep venous thrombosis. Thrombolysis and anticoagulation of intracranial deep venous thrombosis appears to be a safe and efficacious treatment not only in the acute stage but also in the non-acute stage.
