由于多哈回合奉“发展”为主题,同时,多哈部长会议的选址、多哈部长会议宣言中确有的一些支持发展中国家成员的内容(特别在知识产权和公众健康宣言中有更明确的表述)以及“执行决定”(Decision on Implementation)表现出的积极态度,令...由于多哈回合奉“发展”为主题,同时,多哈部长会议的选址、多哈部长会议宣言中确有的一些支持发展中国家成员的内容(特别在知识产权和公众健康宣言中有更明确的表述)以及“执行决定”(Decision on Implementation)表现出的积极态度,令不少人相信该回合呈现出“发展中国家成员时代到来”的特征。毋庸讳言,这些前所未有的成果的取得,主要在于发展中国家成员的通力协作以及全球经济日益增长的相互依赖性。事实上,从1947年23个国家签署关贸总协定并开始贸易自由化以来,到经过8年称作“乌拉圭回合”的谈判而成立世贸组织,发展中国家一直呼吁给予他们一个公平的竞争环境。多哈部长会议的“展开更多
Ischemic stroke causes long-term disability and results in motor impairments.Such impairments are associated with structural changes in the neuromuscular junction(NMJ),including detailed morphology and three-dimension...Ischemic stroke causes long-term disability and results in motor impairments.Such impairments are associated with structural changes in the neuromuscular junction(NMJ),including detailed morphology and three-dimensional(3D)distribution.However,previous studies only explored morphological changes of individual NMJs after stroke,which limits the understanding of their role in post-stroke motor impairment.Here,we examine 3D distributions and detailed morphology of NMJs in entire mouse muscles after unilateral and bilateral strokes induced by photothrombosis.The results show that 3D distributions and numbers of NMJs do not change after stroke,and severe unilateral stroke causes similar levels of NMJ fragmentation and area enlargement to bilateral stroke.This research provides structural data,deepening the understanding of neuromuscular pathophysiology after stroke.展开更多
文摘由于多哈回合奉“发展”为主题,同时,多哈部长会议的选址、多哈部长会议宣言中确有的一些支持发展中国家成员的内容(特别在知识产权和公众健康宣言中有更明确的表述)以及“执行决定”(Decision on Implementation)表现出的积极态度,令不少人相信该回合呈现出“发展中国家成员时代到来”的特征。毋庸讳言,这些前所未有的成果的取得,主要在于发展中国家成员的通力协作以及全球经济日益增长的相互依赖性。事实上,从1947年23个国家签署关贸总协定并开始贸易自由化以来,到经过8年称作“乌拉圭回合”的谈判而成立世贸组织,发展中国家一直呼吁给予他们一个公平的竞争环境。多哈部长会议的“
基金supported by the National Natural Science Foundation of China(No.61860206009)the Key Research and Development Project of Hubei Province(No.2022BCA023)the Innovation Fund of WNLO.
文摘Ischemic stroke causes long-term disability and results in motor impairments.Such impairments are associated with structural changes in the neuromuscular junction(NMJ),including detailed morphology and three-dimensional(3D)distribution.However,previous studies only explored morphological changes of individual NMJs after stroke,which limits the understanding of their role in post-stroke motor impairment.Here,we examine 3D distributions and detailed morphology of NMJs in entire mouse muscles after unilateral and bilateral strokes induced by photothrombosis.The results show that 3D distributions and numbers of NMJs do not change after stroke,and severe unilateral stroke causes similar levels of NMJ fragmentation and area enlargement to bilateral stroke.This research provides structural data,deepening the understanding of neuromuscular pathophysiology after stroke.
