Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes an outbreak of corona virus disease 2019(COVID-19)globally.It is to date one of the biggest public health threat in the world.Although studies on this ...Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes an outbreak of corona virus disease 2019(COVID-19)globally.It is to date one of the biggest public health threat in the world.Although studies on this emerging coronavirus have developed rapidly since the COVID-19 case was confirmed,there is much remains unknown about SARS-CoV-2.To better understand the mechanism of cross-species transmission and search for efficient vaccines and therapeutics for COVID-19,animal models are highly required to evaluate countermeasures against emerging COVID-19.An ideal animal model should respond as similar as human be-ings to SARS-CoV-2 infection and show analogical symptoms,reflecting the human beings clinical sign,viral replication,and pathology that can be applied to identify in human beings.Fortunately,several animal models have been developed to study SARS-CoV-2 and aim to find new vaccines,antiviral agents,and Chinese materia medica very shortly.We aim to review the climical presentations of COVID-19 concerning pathologic features in humans and summarize the current animal models'strengths and limitations of use for SARS-CoV-2.展开更多
基金We thank for the funding support from the Key Scientifie Research Projects of Henan Province Colleges and Universities(21 A360021)Natural Science Foundation of Henan Province(202300410259)+1 种基金Postdoctoral Research Startup Project in Henan Province(202001043)Special Program of the Postdoctoral Science Foundation of China(2021 T140184).
文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes an outbreak of corona virus disease 2019(COVID-19)globally.It is to date one of the biggest public health threat in the world.Although studies on this emerging coronavirus have developed rapidly since the COVID-19 case was confirmed,there is much remains unknown about SARS-CoV-2.To better understand the mechanism of cross-species transmission and search for efficient vaccines and therapeutics for COVID-19,animal models are highly required to evaluate countermeasures against emerging COVID-19.An ideal animal model should respond as similar as human be-ings to SARS-CoV-2 infection and show analogical symptoms,reflecting the human beings clinical sign,viral replication,and pathology that can be applied to identify in human beings.Fortunately,several animal models have been developed to study SARS-CoV-2 and aim to find new vaccines,antiviral agents,and Chinese materia medica very shortly.We aim to review the climical presentations of COVID-19 concerning pathologic features in humans and summarize the current animal models'strengths and limitations of use for SARS-CoV-2.
