目的分析糖尿病孕妇血清载脂蛋白M(apolipoprotein M,ApoM)、瘦素、胰岛素及血脂水平变化特征及联动变化关系。方法选取作者医院2016-03/2018-05月孕中期(孕24～28周)糖尿病孕妇80例,孕晚期(分娩前1周)糖尿病孕妇110例,选取同孕期正常...目的分析糖尿病孕妇血清载脂蛋白M(apolipoprotein M,ApoM)、瘦素、胰岛素及血脂水平变化特征及联动变化关系。方法选取作者医院2016-03/2018-05月孕中期(孕24～28周)糖尿病孕妇80例,孕晚期(分娩前1周)糖尿病孕妇110例,选取同孕期正常孕妇为对照组(正常对照1组,n=90;正常对照2组,n=90)。测定血清中ApoM、瘦素、胰岛素及血脂水平,观察各生化指标水平变化特征,并分析各指标间的相关性。结果孕中期糖尿病孕妇组血清ApoM水平明显低于正常对照1组(P<0.001);孕晚期糖尿病孕妇组血清ApoM水平明显高于正常对照2组(P<0.001)。孕中期糖尿病孕妇组胰岛素、胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平明显高于正常对照1组(P均<0.001),而在瘦素上比较无统计学差异(P>0.05);孕晚期糖尿病孕妇组TC、TG、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、LDL-C水平明显高于正常对照2组(P<0.01或0.05),而在胰岛素和瘦素上比较差异无统计学意义(P>0.05)。孕中期与孕晚期糖尿病孕妇的血清ApoM水平与胰岛素、瘦素、TC、TG均具有相关性(r=0.246～0.317,P<0.05),与HDL-C、LDL-C无关。结论糖尿病孕妇血清ApoM表达异常,ApoM可能在妊娠期糖尿病的病理生理过程中发挥作用,且ApoM水平与胰岛素、瘦素、TC、TG均具有相关性。展开更多
Pre-column derivation of and high-performance liquid chromatography(HPLC)with ultraviolet detection were used to detect the epurated artemisinin in Artemisia annua,and the artemisinin content and biomass yield were co...Pre-column derivation of and high-performance liquid chromatography(HPLC)with ultraviolet detection were used to detect the epurated artemisinin in Artemisia annua,and the artemisinin content and biomass yield were compared between the introduced A.annua and the local wild A.annua.The result showed that the quantity of artemisinin was mainly affected by the genetic background,and secondly influenced by the environment and climate of the cultivated region.The seedlings raised with the integrated plate-type paper containers method in greenhouse had longer growth period of A.annua by about 45 days in frigid area.The highest content of artemisinin was 0.555% and the highest biomass yield was(3 526.7±378)kg·hm-2.High artemisinin content and biomass yield together contributed to artimisinin production.The introduced cultivars had a strong capacity to quickly adapt to the circumstance in Heilongjiang.The artemisinin contents reached to the purchasing level.The mean biomass of individual plant was greater than that in its original region.展开更多
文摘目的分析糖尿病孕妇血清载脂蛋白M(apolipoprotein M,ApoM)、瘦素、胰岛素及血脂水平变化特征及联动变化关系。方法选取作者医院2016-03/2018-05月孕中期(孕24～28周)糖尿病孕妇80例,孕晚期(分娩前1周)糖尿病孕妇110例,选取同孕期正常孕妇为对照组(正常对照1组,n=90;正常对照2组,n=90)。测定血清中ApoM、瘦素、胰岛素及血脂水平,观察各生化指标水平变化特征,并分析各指标间的相关性。结果孕中期糖尿病孕妇组血清ApoM水平明显低于正常对照1组(P<0.001);孕晚期糖尿病孕妇组血清ApoM水平明显高于正常对照2组(P<0.001)。孕中期糖尿病孕妇组胰岛素、胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平明显高于正常对照1组(P均<0.001),而在瘦素上比较无统计学差异(P>0.05);孕晚期糖尿病孕妇组TC、TG、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、LDL-C水平明显高于正常对照2组(P<0.01或0.05),而在胰岛素和瘦素上比较差异无统计学意义(P>0.05)。孕中期与孕晚期糖尿病孕妇的血清ApoM水平与胰岛素、瘦素、TC、TG均具有相关性(r=0.246～0.317,P<0.05),与HDL-C、LDL-C无关。结论糖尿病孕妇血清ApoM表达异常,ApoM可能在妊娠期糖尿病的病理生理过程中发挥作用,且ApoM水平与胰岛素、瘦素、TC、TG均具有相关性。
文摘Pre-column derivation of and high-performance liquid chromatography(HPLC)with ultraviolet detection were used to detect the epurated artemisinin in Artemisia annua,and the artemisinin content and biomass yield were compared between the introduced A.annua and the local wild A.annua.The result showed that the quantity of artemisinin was mainly affected by the genetic background,and secondly influenced by the environment and climate of the cultivated region.The seedlings raised with the integrated plate-type paper containers method in greenhouse had longer growth period of A.annua by about 45 days in frigid area.The highest content of artemisinin was 0.555% and the highest biomass yield was(3 526.7±378)kg·hm-2.High artemisinin content and biomass yield together contributed to artimisinin production.The introduced cultivars had a strong capacity to quickly adapt to the circumstance in Heilongjiang.The artemisinin contents reached to the purchasing level.The mean biomass of individual plant was greater than that in its original region.
