White matter hyperintensities(WMHs)on fluid-attenuated inversion recovery(FLAIR)images are imaging features in various neurological diseases and essential markers for clinical impairment and disease progression.WMHs a...White matter hyperintensities(WMHs)on fluid-attenuated inversion recovery(FLAIR)images are imaging features in various neurological diseases and essential markers for clinical impairment and disease progression.WMHs are associated with brain aging and pathological changes in the human brain,such as in Alzheimer’s disease(AD)[1],Parkinson’s disease(PD)[2],cerebral small vessel disease(SVD)[3],multiple sclerosis(MS)[4].展开更多
白质纤维束分割方法通过识别连接不同脑区的白质通路,为脑连接分析提供了重要的神经通路参考信息。然而,传统的白质纤维束分割方法主要依赖于弥散磁共振图像(Diffusion magnetic resonance imaging,dMRI),由于获取弥散磁共振图像比较耗...白质纤维束分割方法通过识别连接不同脑区的白质通路,为脑连接分析提供了重要的神经通路参考信息。然而,传统的白质纤维束分割方法主要依赖于弥散磁共振图像(Diffusion magnetic resonance imaging,dMRI),由于获取弥散磁共振图像比较耗时,这极大地限制了其在临床中的应用。为解决此问题,提出了一种基于T1加权图像的白质纤维束分割方法,通过计算T1加权图像的结构张量来提示可能的纤维走向,进而提高白质纤维束的分割精度。此外,本文在模型训练期间引入弥散磁共振图像的特权信息来指导模型学习,从而提升白质束分割模型性能,具有挑战性的束分割效果提升明显,其中左穹窿(Left fornix,FX_left)的Dice得分提高了5%,右穹窿(Right fornix,FX_right)的Dice得分提高了6%。。本研究弥补了在缺少弥散磁共振图像的场景下无法进行神经通路分析的不足,扩展了神经通路分析的应用场景。展开更多
基金supported by the Fundamental Research Funds for the Central Universities(2022CX1100)the Beijing Municipal Natural Science Foundation(JQ20035)+1 种基金the National Natural Science Foundation of China(81870958 and 81571631)the Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority(XTYB201831)。
文摘White matter hyperintensities(WMHs)on fluid-attenuated inversion recovery(FLAIR)images are imaging features in various neurological diseases and essential markers for clinical impairment and disease progression.WMHs are associated with brain aging and pathological changes in the human brain,such as in Alzheimer’s disease(AD)[1],Parkinson’s disease(PD)[2],cerebral small vessel disease(SVD)[3],multiple sclerosis(MS)[4].
