The effects of QYS on the functions of central GABAergic system in mice brain were investi-gated by determining the release and uptake of label GABA and Glu in the brain slice andextractive synaptic membrane.The drama...The effects of QYS on the functions of central GABAergic system in mice brain were investi-gated by determining the release and uptake of label GABA and Glu in the brain slice andextractive synaptic membrane.The dramatic actions of QYS in the oral group were showed bythe increasing releases of ~3H-GABA and ~3H-Glu after high K^+ stimulation in the anterior partof hemispheres slices.However,the GAD activity in the hippocampus slice of QYS-treatedgroup was not influenced as the PTZ-treated group.No effect of QYS on the uptakes of^3H-GABA and ~3H-Glu in the extractive synaptic membrane was found in the intraperitonealgroup.These results suggested that QYS does influence the functions of central GABAergic sys-tern due to the increasing releases of GABA and Glu in the anterior part of hemispheres,whichmay play an important role in the anticonvulsant action of QYS.展开更多
文摘The effects of QYS on the functions of central GABAergic system in mice brain were investi-gated by determining the release and uptake of label GABA and Glu in the brain slice andextractive synaptic membrane.The dramatic actions of QYS in the oral group were showed bythe increasing releases of ~3H-GABA and ~3H-Glu after high K^+ stimulation in the anterior partof hemispheres slices.However,the GAD activity in the hippocampus slice of QYS-treatedgroup was not influenced as the PTZ-treated group.No effect of QYS on the uptakes of^3H-GABA and ~3H-Glu in the extractive synaptic membrane was found in the intraperitonealgroup.These results suggested that QYS does influence the functions of central GABAergic sys-tern due to the increasing releases of GABA and Glu in the anterior part of hemispheres,whichmay play an important role in the anticonvulsant action of QYS.
