The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis（PTB） among coal workers＇ pneumoconiosis（CWP） patients. A match...The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis（PTB） among coal workers＇ pneumoconiosis（CWP） patients. A matched case-control study was conducted in 86 CWP patients with active PTB and 86 CWP controls without TB. A standardized questionnaire was used for risk factors assessment. Conditioned logistic regression analysis was used to identify associations between the risk factors and active PTB among CWP patients. The results showed that the stage of CWP, poor workplace ventilation, family history of TB, and exposure to TB were independent risk factors for active PTB in patients with CWP with which recommendations for improving work environments, and for case finding activities in patients with CWP could be made.展开更多
目的探讨煤工尘肺(CWP)早期辅助诊断的生物标志物及其临床意义。方法采用立意抽样法,以69例男性煤矿粉尘作业工人为对照组,以67例男性CWP患者为CWP组。采集2组人群血清,以比色法测定其中丙二醛(MDA)及超氧化物歧化酶(SOD)水平,以酶联免...目的探讨煤工尘肺(CWP)早期辅助诊断的生物标志物及其临床意义。方法采用立意抽样法,以69例男性煤矿粉尘作业工人为对照组,以67例男性CWP患者为CWP组。采集2组人群血清,以比色法测定其中丙二醛(MDA)及超氧化物歧化酶(SOD)水平,以酶联免疫吸附法测定白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平,以改良Ellman法测定乙酰胆碱酯酶(AChE)活力。采用Logistic回归模型分析CWP发病的危险因素,采用受试者工作特征(ROC)曲线分析CWP发病进程中的敏感指标。结果与对照组比较,CWP组人群血清中SOD活力下降(中位数:65.1 vs 59.2 kU/L,P<0.05),MDA、IL-6、TNF-α水平均升高(中位数:4.92 vs 6.68μmol/L,129.82 vs 163.18 ng/L,63.90 vs 70.93 ng/L,P<0.05)。Logistic回归分析结果显示,AChE是CWP的保护因素,年龄、慢性呼吸道症状、IL-6、MDA均是CWP的危险因素(P<0.05)。ROC曲线分析结果显示,IL-6和MDA均可作为煤矿粉尘作业工人CWP诊断的早期指标。结论血清中IL-6和MDA水平可作为CWP早期辅助诊断的生物标志物。展开更多
基金supported by the Research program on occupational poisoning and occupational lung disease[2014BAI12B01]
文摘The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis（PTB） among coal workers＇ pneumoconiosis（CWP） patients. A matched case-control study was conducted in 86 CWP patients with active PTB and 86 CWP controls without TB. A standardized questionnaire was used for risk factors assessment. Conditioned logistic regression analysis was used to identify associations between the risk factors and active PTB among CWP patients. The results showed that the stage of CWP, poor workplace ventilation, family history of TB, and exposure to TB were independent risk factors for active PTB in patients with CWP with which recommendations for improving work environments, and for case finding activities in patients with CWP could be made.
文摘目的探讨煤工尘肺(CWP)早期辅助诊断的生物标志物及其临床意义。方法采用立意抽样法,以69例男性煤矿粉尘作业工人为对照组,以67例男性CWP患者为CWP组。采集2组人群血清,以比色法测定其中丙二醛(MDA)及超氧化物歧化酶(SOD)水平,以酶联免疫吸附法测定白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平,以改良Ellman法测定乙酰胆碱酯酶(AChE)活力。采用Logistic回归模型分析CWP发病的危险因素,采用受试者工作特征(ROC)曲线分析CWP发病进程中的敏感指标。结果与对照组比较,CWP组人群血清中SOD活力下降(中位数:65.1 vs 59.2 kU/L,P<0.05),MDA、IL-6、TNF-α水平均升高(中位数:4.92 vs 6.68μmol/L,129.82 vs 163.18 ng/L,63.90 vs 70.93 ng/L,P<0.05)。Logistic回归分析结果显示,AChE是CWP的保护因素,年龄、慢性呼吸道症状、IL-6、MDA均是CWP的危险因素(P<0.05)。ROC曲线分析结果显示,IL-6和MDA均可作为煤矿粉尘作业工人CWP诊断的早期指标。结论血清中IL-6和MDA水平可作为CWP早期辅助诊断的生物标志物。
