Traditional Chinese medicine(TCM)is a precious treasure of the Chinese nation and has unique advantages in the prevention and treatment of diseases.The holistic view of TCM coincides with the new generation of medical...Traditional Chinese medicine(TCM)is a precious treasure of the Chinese nation and has unique advantages in the prevention and treatment of diseases.The holistic view of TCM coincides with the new generation of medical research paradigm characterized by network and system.TCM gave birth to a new method featuring holistic and systematic"network target",a core theory and method of network pharmacology.TCM is also an important research object of network pharmacology.TCM network pharmacology,which aims to understand the network-based biological basis of complex diseases,TCM syndromes and herb treatments,plays a critical role in the origin and development process of network pharmacology.This review introduces new progresses of TCM network pharmacology in recent years,including predicting herb targets,understanding biological foundation of diseases and syndromes,network regulation mechanisms of herbal formulae,and identifying disease and syndrome biomarkers based on biological network.These studies show a trend of combining computational,experimental and clinical approaches,which is a promising direction of TCM network pharmacology research in the future.Considering that TCM network pharmacology is still a young research field,it is necessary to further standardize the research process and evaluation indicators to promote its healthy development.展开更多
基金Supported by the National Natural Science Foundation of Chinaunder GrantNos.60473003,60573073(国家自然科学基金)the Major Research Program of National Natural Science Foundation of Chinaunder GrantNo.60496321(国家自然科学基金重大项目)
基金supported by the National Natural Science Foundation of China(Nos.6201101081,81630103 and 81225025)Tsinghua University Spring Breeze Fund(No.2020-Z99CFY040)Beijing National Research Center for Information Science and Technology(Nos.BNR2019TD01020 and BNR2019-RC01012)。
文摘Traditional Chinese medicine(TCM)is a precious treasure of the Chinese nation and has unique advantages in the prevention and treatment of diseases.The holistic view of TCM coincides with the new generation of medical research paradigm characterized by network and system.TCM gave birth to a new method featuring holistic and systematic"network target",a core theory and method of network pharmacology.TCM is also an important research object of network pharmacology.TCM network pharmacology,which aims to understand the network-based biological basis of complex diseases,TCM syndromes and herb treatments,plays a critical role in the origin and development process of network pharmacology.This review introduces new progresses of TCM network pharmacology in recent years,including predicting herb targets,understanding biological foundation of diseases and syndromes,network regulation mechanisms of herbal formulae,and identifying disease and syndrome biomarkers based on biological network.These studies show a trend of combining computational,experimental and clinical approaches,which is a promising direction of TCM network pharmacology research in the future.Considering that TCM network pharmacology is still a young research field,it is necessary to further standardize the research process and evaluation indicators to promote its healthy development.
