摘要
目的 了解深圳市2011-2012年手足口病聚集性疫情的流行病及病原学特征,为进一步开展防控工作提供依据.方法 应用描述流行病学方法对手足口病疫情资料进行分析,同时对各起疫情采集的标本,采用荧光PCR方法进行肠道病毒71型(EV71)、柯萨奇病毒A16型(CA16)和其他肠道病毒的核酸检测.结果 2011-2012年实验室共收到160起手足口病疫情的标本501份,其中EV71引起的疫情36起,占22.50％;由CA16引起的疫情52起,占32.50％;由其他肠道病毒引起的疫情40起,占25％.各区均有疫情发生,其中南山区84起,占52.50％;罗湖区36起,占22.5％.除8月份以外,其他月份均有疫情发生,3-7月份为发病高峰,9-11月份出现第2个小高峰.男性阳性率72.3％,女性阳性率73.4％.结论 2011-2012年深圳市手足口病聚集性疫情有地区和月份差异;不同性别间的阳性率没有显著性差异;病原体2011年以CA16为主,2012年则是非EV71、非CA16的其他肠道病毒占主导地位.
Objective Analyzing epidemiological characteristics and etiology of hand,foot and mouth disease outbreaks from 2011 to 2012 in Shenzhen to provide the basis for prevention and control of hand,foot and mouth disease.Methods The data about epidemiology of hand,foot and mouth disease outbreaks was analyzed and Viral RNA was used for enterovirus type 71 (EV71),coxsackie virus type A16 (CA16) and Pan-enterovirus (PE) detection by real-time RT-PCR.Results A total of 501 specimens from 160 hand,foot and mouth disease outbreaks were collected and detected between 2011 and 2012.EV71 was responsible for 36 outbreaks (22.50％),CA16 was responsible for 52 outbreaks (32.50％) and other enteroviruses were responsible for 40 outbreaks (25％).84 outbreaks (52.50％) occurred in Nanshan District in Shenzhen and 36 outbreaks (22.50％) occurred in Luohu District in Shenzhen.Outbreaks occurred throughout the year except August between 2011 and 2012.There were two peak periods from March to July and September to November,respectively.The positive rates of male and female are 72.3％ and 73.4％,respectively.Conclusion There was variation in hand,foot and mouth disease outbreaks in different regions and months.There was no significant difference between gender.CA16 was the main causative agent of hand,foot and mouth disease in 2011,while non-EV71and non-CA16 human enterovirus were main pathogens of hand,foot and mouth disease outbreaks in 2012.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2016年第6期-,共4页
Chinese Journal of Experimental and Clinical Virology
基金
深圳市科技创新委知识创新计划，Knowledge Innovation Program of Shenzhen Municipal Science and Technology Innovation
关键词
手足口病
聚集性疫情
肠道病毒71型
柯萨奇病毒A16型
Hand foot and mouth disease
Clustering in outbreak
Enterovirus type 71 (EV71)
Coxsackievirus A16 (CA16)
