摘要
目的 评价膀胱灌注透明质酸钠联合膀胱区极超短波照射治疗腺性膀胱炎的疗效.方法 回顾性分析2013年3月至2016年3月我们收治的22例行膀胱灌注透明质酸钠联合膀胱区极超短波照射治疗的腺性膀胱炎患者的临床资料.男1例,女21例.年龄41~65岁,中位年龄52岁.尿隐血阳性12例.病程3个月~5年.行膀胱镜检查对病变区进行观察,并取黏膜行病理检查.在治疗前及疗程结束后分别行盆腔疼痛+尿频/尿急症状评分、膀胱炎组织学评分,计数镜下浸润淋巴细胞、布氏巢或囊腔数量,记录残余尿量,将上述评分及数值进行自身对照的统计学分析,并记录治疗期间患者的不良反应,对治疗效果进行评价.结果 22例患者在疗程结束后,盆腔疼痛+尿频/尿急症状评分、膀胱炎组织学评分,以及镜下计数浸润淋巴细胞、布氏巢或囊腔数量及残余尿量较治疗前指标均有所下降或减轻,差异有统计学意义(P<0.01),1例患者连续2次在膀胱灌注透明质酸钠后出现一过性全身皮肤瘙痒,无其他严重不良反应.结论 膀胱灌注透明质酸钠联合膀胱区极超短波照射治疗腺性膀胱炎的疗效明确,无严重并发症,为腺性膀胱炎的治疗提供了新的思路.
Objective To evaluate the efficacy of bladder perfusion with sodium hyaluronate combined with ultrashort wave irradiation in bladder region in treatment of glandular cystitis.Methods 22 patients diagnosed as typical glandular cystitis were selected from our hospital between March 2013 and March 2013. Those patients were given bladder perfusion with sodium hyaluronate combined with ultrashort wave irradiation in bladder region according to the designed course. The lesion areas were taked photos and bited samples for microscopic observation and HE staining.The evaluation indicators include pelvic pain and urgency/frequency symptom scores,cystitis histologic scores ,infiltrating lymphocyte counts, Brunn nest or cystica counts and residual urine volume were measured in the self-control expertiment before treatment and after. Results Over the course of treatment, above mentioned indicators had significant improvement compared with original data among those patients (P<0.01).Only 1 patient appeared itchy skin two times after bladder perfusion with sodium hyaluronate, others without serious complications. Conclusions The method that bladder perfusion with sodium hyaluronate combined with ultrashort wave irradiation has clear effect without serious complications.This method provides a new train of thought for glandular cystitis and opens up a new space.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2017年第S1期34-39,共6页
Chinese Journal of Urology
基金
兖矿集团2015年重大科研项目
关键词
透明质酸钠
极超短波照射
膀胱灌注
腺性膀胱炎
Cystitis glandularis
Sodium hyaluronate
Ultrashort wave irradiation
Bladder perfusion
