摘要
目的：探讨桉柠蒎对支气管扩张并感染患者的疗效。方法采用前瞻性随机对照研究，将2013年6月至2015年6月入住福建省福州肺科医院呼吸内科的150例支气管扩张并感染患者随机分为对照组、氨溴索组和桉柠蒎组，各50例。对所得的试验数据进行统计分析，各组临床疗效、感染复发情况及不良反应发生情况比较采用χ2检验或 Fisher 确切概率法，临床症状评分、抗生素应用时间和住院时间比较采用 t 检验或单因素方差分析，C 反应蛋白水平比较采用非参数秩和检验。结果经1个疗程（7 d）治疗后，桉柠蒎组的临床疗效均明显优于氨溴索组和对照组（92.0% vs.76.0% vs.6.0%，均P＜0.05）；桉柠蒎组的临床症状评分[（3.9±1.2）分]、抗生素应用时间[（10.6±3.2）d]和住院时间[（11.3±3.4）d]均明显低于氨溴索组[临床症状评分（6.1±1.9）分，抗生素应用时间（14.3±5.3）d，住院时间（15.1±4.9）d]和对照组[临床症状评分（9.1±2.1）分，抗生素应用时间（15.2±5.4）d，住院时间（17.5±5.1）d]，差异均有统计学意义（均 P＜0.05）；桉柠蒎组和氨溴索组的 C 反应蛋白水平均低于对照组[9.1（19.4）mg vs.10.4（27.1）mg vs.22.9（28.9）mg，均 P＜0.05]。出院后3个月内，桉柠蒎组的感染复发率均明显低于氨溴索组和对照组（4.0% vs.20.0% vs.16.0%，均 P＜0.05）。3组不良反应的发生率均较低（6.0% vs.8.0% vs.6.0%），症状轻微，差异无统计学意义（P＞0.05）。结论桉柠蒎可以提高支气管扩张并感染的临床疗效，缩短抗生素应用时间和住院时间，降低患者的再次感染风险，药物安全有效，具有良好的临床应用价值。
Objective To investigate the clinical effect of eucalyptol-limonene-pinene (ELP) enteric capsule in the treatment of bronchiectasis with infection. Methods 150 cases of adult patients in Fuzhou Pulmonary Hospital of Fujian diagnosed with bronchiectasis with infection were randomly assigned into three groups: control group (n=50) with conventional treatment, ambroxol group (n=50) with conventional treatment combined with ambroxol and ELP group (n=50) with conventional treatment combined with ELP. All the data were recorded and compared. Clinical effect, recurrence rate of pulmonary infection and incidence of adverse drug reactions (ADR) were compared using χ2 test or Fisher exact test. Score of clinical symptoms, duration of antibiotic treatment and length of hospital stay were compared using t test or one-way ANOVA. Level of C-reaction protein (CRP) was compared using non-parameters Wilcoxon test. Results After 7 days of treatment, the total effective rate in the ELP group was higher than the ambroxol group and the control group (92.0% vs. 76.0% vs. 56.0%, P<0.05). The score of clinical symptoms was significantly decreased in the ELP group compared with the ambroxol group and the control group ((3.9±1.2)scores vs. (6.1±1.9)scores vs. (9.1±2.1)scores, P<0.05)Patients from the ELP group had a shorter duration of antibiotic treatment than those in the ambroxol group and the control group [(10.6±3.2)d vs. (14.3±5.3)d vs. (15.2±5.4)d, P<0.05] and were discharged from the hospital earlier than those in the other groups ((11.3±3.4)d vs. (15.1±4.9)d vs. (17.5±5.1)d, P<0.05)The level of C-reaction protein (CRP) was significantly decreased in the ELP group and ambroxol group compared with the control group (9.1 (19.4)mg vs. 10.4 (27.1)mg vs. 22.9 (28.9)mg, P<0.05)The recurrence rate of pulmonary infection in the ELP group was 4.0%, which was significantly lower than 20.0% in the ambroxol group and 16.0% in the control group within 3 months after discharge, and the difference was statistically significant (P<
出处
《中华临床医师杂志（电子版）》
CAS
2016年第24期-,共5页
Chinese Journal of Clinicians(Electronic Edition)
