摘要
1985年至1987年底,在彻底清除病灶的基础上,应用先锋霉素珠链治疗小儿慢性骨髓炎27例,全部治愈.本文结合临床资料,对小儿慢性骨髓炎的病因、发病年龄、病程,放射学、细菌学、白细胞、血沉变化等病理特点进行了综合分析;结合实验研究与临床应用结果,对先锋霉素珠链治疗骨髓炎的作用机制与治疗效果,影响疗效的因素及值得注意的问题等,进行了详细讨论.
Experiments in vitro and in vivo revealed that Cephaloridine or Cefazoline combined with Polymethylmethacrylate (PMMA)will release,in the body continuously,a therapeutic concentration inhibiting several kinds of pathogenic bacteria for at least 8 weeks,This drug-combination has been successfully made in form of beads which are later made into a chain,so call 'beads-chain'.From 1985 to 1987,32 children with aucte or chronic osteomyelitis were treated with Cephaloridine or Cefazoline-PMMA 'beads-chain'.Among them,31 were cured.After a thourough debridement,the 'beadschain' is imbedded in the sutured wound along its whole length of the tract leaving two beads extending outside the skin.7 days later,2 of 3 beads are pulled out and removed every other day,and this chain will be removed completely within 2 to 3 weeks and the sinus will heal in 4 of 5 days.This is a new method in the treatment of acute of chronic osteomyelitis and also in the prevention of bone and soft tissue infections in open fractures.
出处
《中华小儿外科杂志》
CSCD
1989年第6期359-360,共2页
Chinese Journal of Pediatric Surgery
