摘要
目的 :探讨利培酮治疗酒精所致精神障碍的疗效。方法 :选取了80例酒精所致精神障碍患者,按随机数字表法分为两组,氯丙嗪组(39例)口服氯丙嗪片治疗,利培酮组(41例)口服利培酮片,通过观察两组治疗前后PANSS评分,HAMA,HAMD,Fugl-Meyer评分及随访期间不良反应发生情况,评价利培酮治疗酒精所致精神障碍的疗效。结果 :治疗前两组阳性症状、阴性症状、精神病理及PANSS总分对比,无统计学差异。治疗后,两组阳性症状、阴性症状、精神病理及PANSS总分均明显下降,且利培酮组患者阴性症状、精神病理及PANSS总分较低。治疗前两组HAMA和HAMD、Fugl-Meyer评分对比,无统计学差异,治疗后两组HAMA和HAMD评分均明显降低,且观察组分值更低。治疗后两组Fugl-Meyer评分均明显增加,且观察组分值更高,治疗期间,氯丙嗪组震颤、视物模糊的发生率明显高于利培酮组。结论 :利培酮对酒精所致精神障碍具有较好的疗效,能改善患者焦虑、抑郁情绪,提高患者运动和协调功能。用药后主要不良反应为锥体外系反应,严重不良反应为心动过速,故应服药期间应重点监测患者锥体外系反应和心功能。
Objective To discuss the efficacy of risperidone in the treatment of mental disorders due to alcohol. Methods 80 patients with mental disorders due to alcohol were selected, they were divided into two groups randomly. The chlorpromazine group (39 cases) was given chlorpromazine. The risperidone group (41 cases) was given risperidone. The efficacy of risperidone in the treatment of mental disorders due to alcohol was evaluated by PANSS, HAMA, HAMD, Fugl-Meyer and adverse reac-tion during treatment. Results Before treatment, there were no statistical significance on positive symptoms, negative symptoms, psychiatric and PANSS scores between two groups. After treatment, the positive symptoms, negative symptoms, psychiatric and PANSS scores were decreased in two groups. The scores in risperidone group were lower. Before treatment, there were no sta-tistical significance on HAMA, HAMD, Fugl-Meyer scores between two groups. . After treatment, the HAMA, HAMD scores of two groups were decreased in two groups. The scores in risperidone group were lower. The Fugl-Meyer scores were increased in two groups. The scores in risperidone group were higher. During treatment, the tremor and blurred vision incidence of chlo-rpromazine group was higher than that of the risperidone group. Conclusion The risperidone had a good curative effect on mental disorder due to alcohol. It could improve the symptoms of anxiety and depression, movement and coordination function. The main adverse reaction was extrapyramidal reactions. The serious adverse reaction was tachycardia. Therefore, the patients should be monitored during treatment.
出处
《湖南师范大学学报（医学版）》
2017年第4期-,共3页
Journal of Hunan Normal University(Medical Sciences)
关键词
利培酮
氯丙嗪
酒精
精神障碍
锥体外系反应
risperidone
chlorpromazine
alcohol
mental disorder
extrapyramidal reactions
