摘要
目的 :观察吉奥在老年进展期胃癌患者中的应用及对AEG-1/MT qDH、NF-κB、MMP-9水平的影响。方法 :取胃癌患者100例,随机分为对照组(n=45)和观察组(n=45)。对照组采用胃切除术治疗,观察组联合替吉奥化疗治疗,采用免疫组织化学法检测2组患者AEG-1/MT qDH、NF-κB、MMP-9水平,比较两组临床疗效及对AEG-1/MT qDH、NF-κB、MMP-9水平的影响。结果 :观察组治疗后1年生存率、3年生存率及5年生存率,高于对照组;观察组治疗后AEG-1/MT qDH、NF-κB、MMP-9水平,显著低于对照组;观察组治疗后并发症发生率为22.00%,与对照组的18.00%相比差异无统计学意义。结论 :胃癌患者在胃切除治疗基础上联合替吉奥治疗效果理想,能降低AEG-1/MT qDH、NF-κB、MMP-9水平,值得推广应用。
Objective To observe the effect of Gluconate on the expression of qDH, NF-κB and MMP-9 in aged patients with advanced gastric cancer.Methods100 patients with gastric cancer were randomly divided into the control group (n =45) and the observation group (n =45). The levels of qDH, NF-κB and MMP-9 in AEG-1 / MT were detected by immunohisto-chemical method in the control group. The clinical efficacy of the two groups was compared with that of AEG1 / MT qDH, NF-κB and MMP-9 in patients with acute myocardial infarction.Results The1-year survival rate,3-year survival rate and5-year survival rate in the observation group were higher than those in the control group. The levels of qDH, NF-κB and MMP-9 in the AEG-, Which was significantly lower than that of the control group. The incidence of complications was 22.00% in the observa-tion group and 18.00% in the control group .Conclusion The combination therapy of gastric cancer with gastric cancer is effec-tive and can reduce the levels of qDH, NF-κB and MMP-9 of AEG-1 / MT and is worthy of popularization and application.
出处
《湖南师范大学学报（医学版）》
2017年第3期-,共3页
Journal of Hunan Normal University(Medical Sciences)
